INT5525

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Context Info
Confidence 0.66
First Reported 1992
Last Reported 2006
Negated 0
Speculated 3
Reported most in Abstract
Documents 3
Total Number 9
Disease Relevance 0.44
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna2) plasma membrane (Chrna2)
Anatomy Link Frequency
bladder 3
muscle cells 1
spinal cord 1
brain 1
obturator nerve 1
Chrna2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 6 99.56 Very High Very High Very High
tetrodotoxin 7 99.36 Very High Very High Very High
qutenza 6 25.00 Low Low
Disease Link Frequency Relevance Heat
Overactive Bladder 12 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PURPOSE: We investigated the effects of nicotinic acetylcholine receptor activation in the bladder and central nervous system on the micturition reflex in urethane anesthetized rats.
Spec (investigated) Positive_regulation (activation) of nicotinic acetylcholine receptor in bladder associated with overactive bladder and central nervous system
1) Confidence 0.66 Published 2006 Journal J. Urol. Section Abstract Doc Link 16753446 Disease Relevance 0.17 Pain Relevance 0.05
In the central nervous system nicotinic acetylcholine receptor activation in the spinal cord and brain has an excitatory and an inhibitory effect on the micturition reflex, respectively.
Positive_regulation (activation) of nicotinic acetylcholine receptor in brain
2) Confidence 0.58 Published 2006 Journal J. Urol. Section Body Doc Link 16753446 Disease Relevance 0 Pain Relevance 0
MATERIALS AND METHODS: The effects of nicotinic acetylcholine receptor activation on bladder activity were examined during continuous infusion cystometrogram.
Positive_regulation (activation) of nicotinic acetylcholine receptor in bladder
3) Confidence 0.48 Published 2006 Journal J. Urol. Section Body Doc Link 16753446 Disease Relevance 0.10 Pain Relevance 0
CONCLUSIONS: These results indicate that nicotinic acetylcholine receptor activation in capsaicin sensitive C-fiber afferents in the bladder can induce detrusor overactivity.
Positive_regulation (activation) of nicotinic acetylcholine receptor in bladder
4) Confidence 0.48 Published 2006 Journal J. Urol. Section Body Doc Link 16753446 Disease Relevance 0 Pain Relevance 0
This work addresses the physiological regulation of skeletal muscle acetylcholinesterase (AChE) isoforms by examining endplate-enriched samples from adult rat gracilis muscles 48 h after: low-intensity treadmill exercise; obturator nerve transection; nerve impulse conduction blockade by tetrodotoxin; acetylcholine (ACh) receptor (AChR) inactivation by alpha-bungarotoxin; and, addition of obturator nerve extracts to muscles in organ culture.
Positive_regulation (inactivation) of AChR in obturator nerve associated with tetrodotoxin
5) Confidence 0.38 Published 1992 Journal Neurochem. Res. Section Abstract Doc Link 1311432 Disease Relevance 0 Pain Relevance 0.10
PURPOSE: We investigated the effects of nicotinic acetylcholine receptor activation in the bladder and central nervous system on the micturition reflex in urethane anesthetized rats.
Spec (investigated) Positive_regulation (activation) of nicotinic acetylcholine receptor in central nervous system associated with overactive bladder and central nervous system
6) Confidence 0.23 Published 2006 Journal J. Urol. Section Abstract Doc Link 16753446 Disease Relevance 0.17 Pain Relevance 0.05
In the central nervous system nicotinic acetylcholine receptor activation in the spinal cord and brain has an excitatory and an inhibitory effect on the micturition reflex, respectively.
Positive_regulation (activation) of nicotinic acetylcholine receptor in spinal cord
7) Confidence 0.20 Published 2006 Journal J. Urol. Section Body Doc Link 16753446 Disease Relevance 0 Pain Relevance 0
To determine whether mRNA expression was transient and did not result in steady-state upregulation of AChR receptor protein, we performed a double labeling of surface AChRs with 125I-alpha-bungarotoxin (125I-alpha-BTX) concomitant to the in situ hybridization for mRNA quantification on TTX treated muscle cells.
Spec (whether) Positive_regulation (upregulation) of AChR in muscle cells associated with tetrodotoxin
8) Confidence 0.10 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9459482 Disease Relevance 0 Pain Relevance 0.22
We investigated the functional relationship between nuclear topology, as expressed by degree and type of nuclear aggregation, and appearance of acetylcholine receptor (AChR) subunit mRNAs.
Positive_regulation (appearance) of AChR
9) Confidence 0.07 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9459482 Disease Relevance 0 Pain Relevance 0.18

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