INT55251

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Context Info
Confidence 0.67
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 142
Total Number 142
Disease Relevance 81.21
Pain Relevance 23.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (a) generation of precursor metabolites and energy (a) extracellular region (a)
Anatomy Link Frequency
liver 49
melanocytes 10
ileum 4
bars 3
tail 3
a (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 3391 100.00 Very High Very High Very High
Central nervous system 75 99.96 Very High Very High Very High
antagonist 118 99.74 Very High Very High Very High
opioid receptor 4 97.86 Very High Very High Very High
agonist 140 96.20 Very High Very High Very High
Kinase C 23 76.24 Quite High
Opioid 4 75.00 Quite High
adenocard 1 63.44 Quite High
narcan 4 56.32 Quite High
tolerance 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 5237 100.00 Very High Very High Very High
Cancer 1900 100.00 Very High Very High Very High
Obesity 2489 99.84 Very High Very High Very High
Freckles 718 99.80 Very High Very High Very High
Diabetes Mellitus 825 99.72 Very High Very High Very High
Syndrome 525 99.66 Very High Very High Very High
Hyperinsulinism 525 99.56 Very High Very High Very High
Body Weight 975 99.48 Very High Very High Very High
Liver Cancer 825 99.36 Very High Very High Very High
Sprains And Strains 257 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Through which signaling pathway does ASIP/MC1R induce biological effects, if not through reduced cAMP?
Gene_expression (/) of ASIP associated with melanocortin 1 receptor
1) Confidence 0.67 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0.08 Pain Relevance 0.30
Mice with null mutations at the attractin (Atrn, formerly mahogany) or mahogunin (Mgrn1, formerly mahoganoid) loci produce eumelanin and no pheomelanin, even in the presence of ASIP (He et al., 2001, 2003).
Gene_expression (presence) of ASIP
2) Confidence 0.67 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.52
Atrn and Mgrn1-null melanocytes: partial biological responses to ASIP but not ASIP-YY
Gene_expression (responses) of ASIP-YY in melanocytes
3) Confidence 0.67 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.05
The growth inhibition by ASIP apparently also required the N-terminus of ASIP, as it was not produced by ASIP-YY.
Neg (not) Gene_expression (produced) of ASIP-YY
4) Confidence 0.67 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.05
Agouti signaling protein (ASIP)’s morphological effects were very deficient in MGRN1-null melanocytes, consistent with the requirement of MGRN1 for ASIP action in mice.
Gene_expression (action) of ASIP in melanocytes
5) Confidence 0.67 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0.07 Pain Relevance 0.29
Through which signaling pathway does ASIP/MC1R induce biological effects, if not through reduced cAMP?
Neg (not) Gene_expression (induce) of ASIP associated with melanocortin 1 receptor
6) Confidence 0.67 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0.08 Pain Relevance 0.30
Atrn and Mgrn1-null melanocytes: partial biological responses to ASIP but not ASIP-YY
Gene_expression (responses) of ASIP in melanocytes
7) Confidence 0.67 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.05
ASIP-YY displaces NDP-MSH from human melanocortin receptors expressed on HEK-293 human kidney cells, and inhibits ?
Gene_expression (displaces) of ASIP-YY in kidney
8) Confidence 0.67 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.08
To assess the effect of incubation of ASIP in medium, RPMI1640 containing 10% FBS and 100 nM ASIP was incubated under the same conditions for 12 h and this medium was applied in place of the medium with fresh ASIP.
Gene_expression (applied) of ASIP
9) Confidence 0.67 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0
To ensure that our ASIP-YY preparation retained its known inhibitory activity, we evaluated its inhibition of MSH-induced cAMP production in melan-a cells.
Gene_expression (preparation) of ASIP-YY
10) Confidence 0.67 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.06
To quantify Mc1r and Agouti transcript levels in wild type and melanic mice from New Hampshire, we used quantitative real-time PCR to detect Mc1r and Agouti mRNA in the skin of 4-day-old (P4) pups, a time when Agouti expression is high [52].
Gene_expression (expression) of Agouti in skin associated with melanocortin 1 receptor
11) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0 Pain Relevance 0.35
We did not detect any Agouti expression in melanic embryos (Figure 3D).


Gene_expression (expression) of Agouti in embryos
12) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.27 Pain Relevance 0.24
125kb alleles, levels of Agouti expression were significantly higher than those of animals homozygous for a?
Gene_expression (expression) of Agouti
13) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.21 Pain Relevance 0.14
In addition, we performed in situ hybridizations on 12.5 day-old embryos to determine whether Agouti is expressed in melanic embryos.
Gene_expression (expressed) of Agouti in embryos
14) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.24 Pain Relevance 0.21
Pleiotropy is especially well documented in Agouti: ectopic expression of Agouti in Mus can result in obesity and lethality [27], [28] and null mutants in Rattus and Peromyscus exhibit behavioral differences [29], [30].
Gene_expression (expression) of Agouti associated with obesity
15) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.31 Pain Relevance 0.36
At this stage, wild type embryos express Agouti in the whisker plate and in parts of the limbs (Figure 3C), an expression pattern similar to that seen in Mus [20].
Gene_expression (express) of Agouti in whisker
16) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.25 Pain Relevance 0.22
The goal of this research was to determine if ectopic expression of the agouti gene in the liver alone is sufficient to recapitulate any aspect of this syndrome.
Gene_expression (expression) of agouti in liver associated with syndrome
17) Confidence 0.61 Published 2004 Journal Mol Cancer Section Abstract Doc Link PMC443512 Disease Relevance 1.10 Pain Relevance 0.22
These results demonstrate that agouti expression in the liver is sufficient to promote liver carcinogenesis, independent of any other apparent agouti-mediated physiological effects.
Gene_expression (expression) of agouti in liver
18) Confidence 0.61 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 0.68 Pain Relevance 0
Mice in the middle of the spectrum exhibit a moderate level of ubiquitous agouti expression, have coats that are a patchwork of yellow and agouti hairs (i.e., mottled), and are likely to become obese and hyperinsulinemic.
Gene_expression (expression) of agouti in hairs associated with obesity
19) Confidence 0.61 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.03 Pain Relevance 0
In addition to a role in the central nervous system, agouti expression in adipose tissue also appears to contribute to the obesity syndrome.
Gene_expression (expression) of agouti in adipose tissue associated with syndrome, obesity and central nervous system
20) Confidence 0.61 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.17 Pain Relevance 0.12

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