INT55255

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Context Info
Confidence 0.69
First Reported 1994
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 48
Total Number 48
Disease Relevance 24.88
Pain Relevance 12.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
macrophages 10
microglia 10
astrocytes 6
T-cell 6
smooth muscle cells 4
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 512 100.00 Very High Very High Very High
cytokine 194 100.00 Very High Very High Very High
Inflammatory response 187 100.00 Very High Very High Very High
Calcitonin gene-related peptide 32 100.00 Very High Very High Very High
Inflammatory mediators 12 100.00 Very High Very High Very High
Hyperalgesia 6 100.00 Very High Very High Very High
dexamethasone 20 99.84 Very High Very High Very High
antagonist 58 99.80 Very High Very High Very High
ischemia 17 99.74 Very High Very High Very High
intrathecal 12 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 687 100.00 Very High Very High Very High
Neurodegenerative Disease 73 100.00 Very High Very High Very High
Cancer 46 100.00 Very High Very High Very High
Necrosis 34 100.00 Very High Very High Very High
Hyperalgesia 6 100.00 Very High Very High Very High
Common Cold 34 99.90 Very High Very High Very High
Stress 78 99.88 Very High Very High Very High
Alzheimer's Dementia 2 99.88 Very High Very High Very High
Cv Unclassified Under Development 12 99.74 Very High Very High Very High
Injury 82 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In quiescent ulcerative colitis there was enhanced spontaneous secretion of IL-6 but a smaller, non-significant increase after T-cell activation (125%).
Positive_regulation (enhanced) of Localization (secretion) of IL-6 in T-cell
1) Confidence 0.69 Published 1994 Journal Scand. J. Gastroenterol. Section Body Doc Link 7973432 Disease Relevance 0.15 Pain Relevance 0
RESULTS: Stimulation of control specimens increased IL-6 secretion (median increase, 147%; p < 0.003), which was prevented by CsA.
Positive_regulation (increased) of Localization (secretion) of IL-6
2) Confidence 0.69 Published 1994 Journal Scand. J. Gastroenterol. Section Body Doc Link 7973432 Disease Relevance 0.17 Pain Relevance 0
Bacterial lipopolysaccharide increases interleukin-6 and prostaglandin release in rat cortical type I astrocytes by different mechanisms: role of anti-inflammatory agents.
Positive_regulation (increases) of Localization (release) of interleukin-6 in astrocytes associated with inflammation
3) Confidence 0.68 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 9784426 Disease Relevance 0.10 Pain Relevance 0.25
As shown in Figure 3A, in the absence of indomethacin the release of IL-6 was significantly induced by AM exposed to the large 1.5 ?
Positive_regulation (induced) of Localization (release) of IL-6
4) Confidence 0.67 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.17 Pain Relevance 0.08
Whey protein isolate (WPI) had the suppressive effect against ischemia/reperfusion-induced IL-6 release, while casein and bovine serum albumin had no effect.
Positive_regulation (induced) of Localization (release) of IL-6 associated with ischemia
5) Confidence 0.56 Published 2007 Journal Inflammopharmacology Section Abstract Doc Link 17323195 Disease Relevance 0.36 Pain Relevance 0.28
Acute stress in 7 rats also increased the mean amount of IL-6 released in the urine by 31.5% from 775.9 +/- 69.2 to 1,021.1 +/- 93.3 pg.
Positive_regulation (increased) of Localization (released) of IL-6 in urine
6) Confidence 0.50 Published 2002 Journal J. Urol. Section Body Doc Link 11743360 Disease Relevance 0 Pain Relevance 0
Pretreatment with IL-1 receptor antagonist (IL-1ra) attenuated the release of IL-6 and had a marginal effect on the corticosterone response 6 h after turpentine.
Positive_regulation (attenuated) of Localization (release) of IL-6 associated with antagonist
7) Confidence 0.49 Published 1994 Journal Psychoneuroendocrinology Section Abstract Doc Link 8190836 Disease Relevance 0.15 Pain Relevance 0.17
LPS-induced IL-6 release was partially inhibited by BW 4AC, a 5-lipoxygenase inhibitor.
Positive_regulation (LPS-induced) of Localization (release) of IL-6
8) Confidence 0.49 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.25
LPS stimulated IL-6 release in a concentration-dependent manner from rat cortical type I astrocytes.
Positive_regulation (stimulated) of Localization (release) of IL-6 in astrocytes
9) Confidence 0.49 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.21
Neutralisation of endogenous IL-6 with a sheep anti-rat IL-6 serum did not alter heat-induced CGRP release, but abolished the sIL-6R-mediated sensitising effect.
Neg (not) Positive_regulation (heat-induced) of Localization (release) of IL-6 associated with calcitonin gene-related peptide
10) Confidence 0.48 Published 2002 Journal Pain Section Abstract Doc Link 11932061 Disease Relevance 0.12 Pain Relevance 0.70
The role of PGE2 in production of IL-6 by AM is further confirmed by restoration of IL-6 release in AM with 0.5 ?
Positive_regulation (by) of Localization (release) of IL-6
11) Confidence 0.48 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.30 Pain Relevance 0.19
In the presence of indomethacin the IL-6 release increased strongly by both types of particles (**P < 0.005) compared to non-particle baseline.
Positive_regulation (increased) of Localization (release) of IL-6
12) Confidence 0.48 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.15 Pain Relevance 0.08
m Fe2O3 particles caused a substantial IL-6 release from AM (Figure 3A), cellular PGE2 production was much greater with the small 0.5 ?
Positive_regulation (substantial) of Localization (release) of IL-6
13) Confidence 0.48 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.46 Pain Relevance 0.31
Our data supports the hypothesis that soluble iron within AM modulates particle-core induced inflammatory responses via increased PGE2 synthesis and inhibiting IL-6 release.
Positive_regulation (induced) of Localization (release) of IL-6 associated with inflammatory response
14) Confidence 0.48 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.44 Pain Relevance 0.22
Despite aggressive fluid resuscitation, burn trauma produced a time-related increase in cardiomyocyte secretion of IL-1beta, IL-6, and TNF-alpha.
Positive_regulation (increase) of Localization (secretion) of IL-6 in cardiomyocyte associated with burns and injury
15) Confidence 0.48 Published 2002 Journal Shock Section Abstract Doc Link 12392281 Disease Relevance 1.04 Pain Relevance 0.46
CONCLUSIONS: In quiescent ulcerative colitis the enhanced spontaneous secretion of IL-6 may be a consequence of mucosal T-cell or macrophage activation: the smaller increase after T-cell stimulation suggests that one or both of these two cell types are already pre-activated.


Positive_regulation (enhanced) of Localization (secretion) of IL-6 in T-cell
16) Confidence 0.46 Published 1994 Journal Scand. J. Gastroenterol. Section Body Doc Link 7973432 Disease Relevance 0.12 Pain Relevance 0
Treatment with PGE2 further enhanced IL-6 release in a concentration- and time-dependent manner.
Positive_regulation (enhanced) of Localization (release) of IL-6 in PGE2
17) Confidence 0.46 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15836625 Disease Relevance 0.36 Pain Relevance 0.61
To rule out the possibility that DEX was inhibiting LPS-induced IL-6 release by blocking IL-6 gene expression, we tested the effect of DEX on interleukin 1beta(IL-1)-induced IL-6 release.
Positive_regulation (induced) of Localization (release) of IL-6 associated with dexamethasone
18) Confidence 0.46 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.32
Intestinal ischemia and absence of constitutive NOS activity leading to additional intestinal stress both cause release of IL-6 and increase of lung microvascular permeability.
Positive_regulation (cause) of Localization (release) of IL-6 in lung associated with stress, cv general 4 under development and ischemia
19) Confidence 0.45 Published 2009 Journal Shock Section Abstract Doc Link 18838940 Disease Relevance 0.70 Pain Relevance 0.32
In conclusion, increased intracellular soluble iron may modulate Fe2O3 particle-induced IL-6 release and inflammatory response via PGE2 production by AM.
Positive_regulation (induced) of Localization (release) of IL-6 associated with inflammatory response
20) Confidence 0.45 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.82 Pain Relevance 0.30

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