INT5526

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Context Info
Confidence 0.30
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 0.67
Pain Relevance 4.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
NAC 1
neurons 1
cochlear 1
glutamatergic neurons 1
neural 1
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
excitatory amino acid 1 100.00 Very High Very High Very High
Opioid 2 99.96 Very High Very High Very High
Nucleus accumbens 6 99.24 Very High Very High Very High
lidocaine 7 98.32 Very High Very High Very High
depression 2 98.16 Very High Very High Very High
tetrodotoxin 20 94.40 High High
Dynorphin 2 91.68 High High
Enkephalin 8 91.24 High High
agonist 28 90.96 High High
opiate 5 90.60 High High
Disease Link Frequency Relevance Heat
Cognitive Disorder 47 99.18 Very High Very High Very High
Depression 2 98.16 Very High Very High Very High
Cancer 2 84.48 Quite High
Urological Neuroanatomy 4 75.00 Quite High
Body Weight 2 68.76 Quite High
Disease 76 62.00 Quite High
Convulsion 2 49.92 Quite Low
Toxicity 3 43.68 Quite Low
Aging 3 37.52 Quite Low
Dementia 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given the role of the NAC in behavior reinforcement, this 5-HT-ACh interaction may be involved in serotonergic treatment of depression.
ACh Binding (interaction) of in NAC associated with nucleus accumbens and depression
1) Confidence 0.30 Published 1993 Journal Brain Res. Section Abstract Doc Link 8374797 Disease Relevance 0.10 Pain Relevance 0.48
These results suggest that the positive effects of estrogen on cognitive functions might be mediated through the ACh-5-HT interactions.
ACh Binding (interactions) of associated with cognitive disorder
2) Confidence 0.30 Published 2002 Journal Brain Res. Section Abstract Doc Link 12020863 Disease Relevance 0.37 Pain Relevance 0.12
When ACh binds to the binding site, the ion path remains open, allowing positive ions to enter the cell.
ACh Binding (binds) of
3) Confidence 0.30 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2875724 Disease Relevance 0.08 Pain Relevance 0.04
This study also provides biochemical verification of the presence of ACh in cochlear tissues.
ACh Binding (presence) of in cochlear
4) Confidence 0.29 Published 1988 Journal Brain Res. Section Abstract Doc Link 2906266 Disease Relevance 0 Pain Relevance 0.22
The stimuli that release part of the bound exogenous [14C]ACh appear to be similar to those that release glucose-derived tissue-bound ACh formed during normal cerebral metabolism.
ACh Binding (bound) of
5) Confidence 0.29 Published 1980 Journal Neurochem. Res. Section Abstract Doc Link 6771663 Disease Relevance 0 Pain Relevance 0.09
The whole of the bound ACh is released by treatment with acid or by dissolution of the cell membranes.
ACh Binding (bound) of
6) Confidence 0.29 Published 1980 Journal Neurochem. Res. Section Abstract Doc Link 6771663 Disease Relevance 0 Pain Relevance 0.09
Corticostriatal glutamatergic neurons have an important role in the interaction of the ACh-opioid systems.
ACh Binding (interaction) of in glutamatergic neurons associated with opioid
7) Confidence 0.22 Published 1990 Journal Brain Res. Section Abstract Doc Link 1976420 Disease Relevance 0 Pain Relevance 1.52
A theoretical model based on these and other findings considers that: AChR activation by spontaneously released ACh is the only neural factor required for the maintenance of G1 + G2 AChE; the amount of A12 AChE is determined by the combined effects of ACh and another neurogenic substance; although mechanisms intrinsic to myofibers control normal levels of G4 AChE, enhanced production of this isoform is initiated through increasing the frequency of ACh-AChR interactions.
ACh Binding (interactions) of in neural
8) Confidence 0.13 Published 1992 Journal Neurochem. Res. Section Abstract Doc Link 1311432 Disease Relevance 0 Pain Relevance 0.07
We have investigated the interaction between excitatory amino acids and acetylcholine (ACh) on striatal spiny neurons by utilizing intracellular recordings, both in current- and in voltage-clamp mode in rat brain slices.
ACh Binding (interaction) of in neurons associated with excitatory amino acid
9) Confidence 0.11 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9758158 Disease Relevance 0 Pain Relevance 0.05
The ACh and plant extract exerted Rmax 115.5 and 81.6%, with ED50 of 5.91×10?
ACh Binding (extract) of
10) Confidence 0.11 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635640 Disease Relevance 0 Pain Relevance 0.07
It is also unknown whether endogenously released ACh can reach pyramidal ?
ACh Binding (endogenously) of
11) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.23
The latter was particularly of interest because of structural similarities between procaine or lidocaine and acetylcholine (ACh) and because it has been shown that these anesthetic agents interact with the ACh receptor.
ACh receptor Binding (interact) of associated with lidocaine
12) Confidence 0.04 Published 1990 Journal Horm. Metab. Res. Section Abstract Doc Link 1968416 Disease Relevance 0 Pain Relevance 1.02
The carbamate moiety remains bound to the esteratic site of the enzyme for much longer than is the case for the acetate moiety during the hydrolysis of ACh so that the enzyme is inactivated for some time after the parent molecule has disappeared from the circulation.
ACh Binding (bound) of
13) Confidence 0.03 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684084 Disease Relevance 0.12 Pain Relevance 0

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