INT5527

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Context Info
Confidence 0.47
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.42
Pain Relevance 4.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna2) plasma membrane (Chrna2)
Anatomy Link Frequency
muscle 1
Neurons 1
B cell 1
brain 1
myotubes 1
Chrna2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 17 100.00 Very High Very High Very High
Kinase C 1 100.00 Very High Very High Very High
substance P 18 99.84 Very High Very High Very High
narcan 8 98.56 Very High Very High Very High
Calcium channel 1 98.28 Very High Very High Very High
Morphine 4 97.60 Very High Very High Very High
Antinociceptive 3 97.46 Very High Very High Very High
Nicotine 10 96.88 Very High Very High Very High
monoamine 5 96.40 Very High Very High Very High
depression 2 93.80 High High
Disease Link Frequency Relevance Heat
Immunization 2 98.32 Very High Very High Very High
Experimental Autoimmune Myasthenia Gravis 4 94.72 High High
Depression 2 93.80 High High
Experimental Autoimmune Encephalomyelitis 1 92.76 High High
Multiple Sclerosis 2 91.12 High High
Nociception 1 88.92 High High
Pain 3 86.68 High High
Encephalitis 2 75.00 Quite High
Neuritis 1 75.00 Quite High
Poisoning 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results are consistent with the idea that cluster loss caused by carbachol and other receptor agonists results from their interaction with the AChR, and the consequent influx of cations into the myotubes.
AChR Binding (interaction) of in myotubes associated with agonist
1) Confidence 0.47 Published 1986 Journal J. Neurosci. Section Abstract Doc Link 3958790 Disease Relevance 0 Pain Relevance 0.23
These effects were mostly due to a direct drug interaction with the nicotinic AChR blocking the ionic channel in its open conformation.
AChR Binding (interaction) of
2) Confidence 0.44 Published 1985 Journal Fundam Appl Toxicol Section Abstract Doc Link 2868960 Disease Relevance 0.17 Pain Relevance 0.11
These findings suggested that the alpha7 nicotinic acetylcholine receptor subtype is associated with the place aversion induced by naloxone in single-dose morphine-treated rats.
nicotinic acetylcholine receptor Binding (associated) of associated with narcan and morphine
3) Confidence 0.32 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16098507 Disease Relevance 0.07 Pain Relevance 0.91
A theoretical model based on these and other findings considers that: AChR activation by spontaneously released ACh is the only neural factor required for the maintenance of G1 + G2 AChE; the amount of A12 AChE is determined by the combined effects of ACh and another neurogenic substance; although mechanisms intrinsic to myofibers control normal levels of G4 AChE, enhanced production of this isoform is initiated through increasing the frequency of ACh-AChR interactions.
AChR Binding (interactions) of in neural
4) Confidence 0.28 Published 1992 Journal Neurochem. Res. Section Abstract Doc Link 1311432 Disease Relevance 0 Pain Relevance 0.07
Oral tolerization with acetylcholine receptor (AChR) and myelin basic protein (MBP) prior to immunization with AChR+MBP+ complete Freund's adjuvant (CFA) alleviated clinical signs of experimental autoimmune myasthenia gravis (EAMG)+experimental allergic encephalomyelitis (EAE) and AChR- or MBP-specific T and B cell responses.
AChR Binding (tolerization) of in B cell associated with multiple sclerosis, immunization, experimental autoimmune myasthenia gravis and experimental autoimmune encephalomyelitis
5) Confidence 0.28 Published 1998 Journal J. Neurol. Sci. Section Abstract Doc Link 9562316 Disease Relevance 0.86 Pain Relevance 0.20
Differences between the antinociceptive effects of the cholinergic channel activators A-85380 and (+/-)-epibatidine in rats.

(+/-)-Epibatidine (EPIB) and A-85380 are nicotinic acetylcholine receptor (nAChR) agonists that bind to the agonist ([3H]cytisine) binding site with 40 to 50 pM affinity but have different affinities in nAChR subtype selective functional receptor assays.

nicotinic acetylcholine receptor Binding (bind) of associated with agonist and antinociceptive
6) Confidence 0.25 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9864263 Disease Relevance 0.26 Pain Relevance 0.74
We interpret this inhibition in solubilized membranes as evidence that the peptide may interact directly with a binding site on the nicotinic acetylcholine receptor.
nicotinic acetylcholine receptor Binding (interact) of
7) Confidence 0.24 Published 1987 Journal Mol. Pharmacol. Section Abstract Doc Link 2446113 Disease Relevance 0 Pain Relevance 0.57
The effect of substance P on the binding of many ligands that interact with the nicotinic acetylcholine receptor was examined in membrane preparations of Torpedo electroplaque and BC3H-1 cells and in solubilized membranes of rat, chick, and goldfish brain.
nicotinic acetylcholine receptor Binding (interact) of in brain associated with substance p
8) Confidence 0.24 Published 1987 Journal Mol. Pharmacol. Section Abstract Doc Link 2446113 Disease Relevance 0 Pain Relevance 0.27
We conclude that monoamine-uptake inhibitors reduce ACh-currents and that imipramine regulates reversibly and non- competitively neuronal alpha2beta4 and muscle AChRs through similar mechanisms, perhaps by interacting externally on a non-conducting state of the AChR and by blocking the open receptor-channel complex close to the vestibule of the channel.
AChR Binding (interacting) of in muscle associated with monoamine
9) Confidence 0.17 Published 2001 Journal Mol. Psychiatry Section Abstract Doc Link 11526465 Disease Relevance 0 Pain Relevance 0.22
Neurons from both species possess the nicotinic acetylcholine receptor.
nicotinic acetylcholine receptor Binding (possess) of in Neurons
10) Confidence 0.05 Published 2001 Journal Neuroscience Section Abstract Doc Link 11311803 Disease Relevance 0 Pain Relevance 0.52
The EC50 values for propofol and etomidate are in the ┬ÁM ranges, but propofol binds to protein kinase C (Hemmings and Adamo, 1994), the nicotinic acetylcholine receptor (nAChR) (Dilger et al., 1994), the L-type calcium channel (Zhou et al., 1997) and the ?
nicotinic acetylcholine receptor Binding (binds) of associated with kinase c and calcium channel
11) Confidence 0.02 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0.06 Pain Relevance 0.16

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