INT55291

Context Info Confidence 0.68 First Reported 1994 Last Reported 2010 Negated 1 Speculated 2 Reported most in Body Documents 20 Total Number 22 Disease Relevance 11.46 Pain Relevance 2.16

transport (Slc2a1) transmembrane transporter activity (Slc2a1) plasma membrane (Slc2a1) intracellular (Slc2a1) transmembrane transport (Slc2a1) cytoplasm (Slc2a1)

Anatomy Link Frequency endothelial cells 5 spinal cords 2 body 2 plasma 1 lymph node 1 Slc2a1 (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 377 99.84 anesthesia 41 99.52 Inflammation 89 98.88 medulla 36 92.40 Central nervous system 107 91.32 imagery 125 90.48 withdrawal 1 88.08 chemokine 3 83.40 cytokine 53 82.80 midbrain 13 63.88

Disease Link Frequency Relevance Heat Targeted Disruption 186 99.88 Cancer 179 99.58 Disease 619 99.00 INFLAMMATION 105 98.88 Breast Cancer 136 98.86 Cerebral Edema 27 97.04 Necrosis 9 96.36 Motor Neuron Diseases 327 95.36 Lobular Carcinoma 8 92.48 Hypoxia 6 88.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Strikingly, however, overexpression of GLUT-1 in muscle induced a profound reduction in insulin-stimulated whole body glucose disposal.

Gene_expression (overexpression) of GLUT-1 in body

1) Confidence 0.68 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7977725 Disease Relevance 0.35 Pain Relevance 0.06

Fasted mice overexpressing GLUT-1 in skeletal muscle exhibited a GIR that was only 54% that of controls (19.3 +/- 1.8 vs. 36.0 +/- 3.9 mg.kg-1.min-1) when blood glucose was clamped at euglycemic values.

Gene_expression (overexpressing) of GLUT-1 in blood

2) Confidence 0.68 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7977725 Disease Relevance 0.38 Pain Relevance 0.10

The effect of glucose transporter expression on insulin-stimulated whole body glucose disposal was examined in transgenic mice overexpressing GLUT-1 or GLUT-4.

Spec (examined) Gene_expression (overexpressing) of GLUT-1 in body associated with targeted disruption

3) Confidence 0.68 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7977725 Disease Relevance 0.27 Pain Relevance 0.09

Differential effects of GLUT-1 or GLUT-4 overexpression on insulin responsiveness in transgenic mice.

Gene_expression (overexpression) of GLUT-1 associated with targeted disruption and anesthesia

4) Confidence 0.68 Published 1994 Journal Am. J. Physiol. Section Title Doc Link 7977725 Disease Relevance 0.41 Pain Relevance 0.19

This downregulation of Glut-1 expression in the endothelial cells of the BSCB may be related to altered endothelial lining leading to vascular leakage.

Gene_expression (expression) of Glut-1 in endothelial cells

5) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.49 Pain Relevance 0.03

Downregulation of Glut-1 and CD146 expressions in spinal cord endothelial cells was also found in G93A mice at early and late stage disease and may relate to altered endothelial lining leading to vascular leakage.

Gene_expression (expressions) of Glut-1 in endothelial cells associated with disease and spinal cord

6) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 1.24 Pain Relevance 0.15

In the present study, we found low and mostly absent expression of Glut-1 in capillaries of both cervical and lumbar spinal cords of G93A mice at early and late stages of disease.

Neg (absent) Gene_expression (expression) of Glut-1 in spinal cords associated with disease

7) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.46 Pain Relevance 0.03

Although additional experiments such as quantitative analysis of Glut-1 distribution and density in the endothelial plasma membranes are needed to elucidate the regulatory mechanisms of Glut-1 expression in the spinal cord, the present study indicates that alteration of Glut-1 could be involved in the pathogenesis of ALS.

Gene_expression (expression) of Glut-1 in spinal cord associated with motor neuron diseases and spinal cord

8) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.54 Pain Relevance 0.08

Alternatively, decreased Glut-1 expression may result from aggravated alterations of the BSCB in G93A mice.

Gene_expression (expression) of Glut-1

9) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.52 Pain Relevance 0.04

Glut-1 expression was increased in WT and eNOS KO mice.

Gene_expression (expression) of Glut-1

10) Confidence 0.45 Published 2006 Journal Acad Emerg Med Section Body Doc Link 16551773 Disease Relevance 0.07 Pain Relevance 0

Additionally, downregulation of Glut-1 and CD146 expressions in the endothelial cells of the BSCB may be related to altered endothelial lining leading to vascular leakage.

Gene_expression (expressions) of Glut-1 in endothelial cells

11) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.68 Pain Relevance 0.11

Additionally, downregulation of Glut-1 and CD146 expressions in the endothelial cells of the BSCB were found which may relate to vascular leakage.

Gene_expression (expressions) of Glut-1 in endothelial cells

12) Confidence 0.44 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2075163 Disease Relevance 0.28 Pain Relevance 0.08

In search for the signs of BBB damage in the brain of symptomatic A53T mice, we examined the expression and subcellular distribution of aquaporin 4, glucose transporter 1 (Glut1) and von Willebrand factor (vWF) in astrocyte and vascular endothelial cells.

Spec (examined) Gene_expression (expression) of Glut1 in endothelial cells associated with targeted disruption

13) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0.45 Pain Relevance 0.26

50, Chemicon), rabbit anti-mouse Glut-1 polyclonal antibody (1?

Gene_expression (antibody) of Glut-1

14) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0 Pain Relevance 0.13

Immunofluorescent staining for Glut-1 (glucose transporter 1) showed high expression of Glut-1 in microvascular endothelia of the cervical and lumbar ventral horn of the spinal cords in C57BL/6J mice at 12–13 weeks of age (Figure 8A, B, H, I) and at 19–20 weeks of age (Figure 8C, J).

Gene_expression (expression) of Glut-1 in horn

15) Confidence 0.39 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.35 Pain Relevance 0.09

The expression of GLUT4 or GLUT1 was not modified by chronic treatment with IL-6 (Fig. 2E).

Gene_expression (expression) of GLUT1

16) Confidence 0.38 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.14 Pain Relevance 0.04

Cells were submitted to subcellular fractionation for plasma membrane and internal membrane isolation before immunoblotting with GLUT4, GLUT1, and caveolin-1 antibodies (8).

Gene_expression (antibodies) of GLUT1 in plasma

17) Confidence 0.33 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0 Pain Relevance 0.03

In the brain, GLUT1, GLUT2 and GLUT5 are expressed predominantly in a cell-specific manner [56-58].

Gene_expression (expressed) of GLUT1 in brain

18) Confidence 0.17 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0 Pain Relevance 0.11

Notable findings for irradiated tumors as compared to control tumors were high levels of Glut-1 expression (13 of 15 tumors), HK II (9 of 16 tumors), and Ki-67 expression (12 of 13 tumors).

Gene_expression (expression) of Glut-1 associated with cancer

19) Confidence 0.14 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 1.50 Pain Relevance 0.03

AD patients also characteristically feature a decrease in basal cerebral glucose utilization (CGU) in parietotemporal and posterior cingulate cortex (Fukuyama et al., 1994; Mosconi et al., 2004; Langbaum et al., 2009), altered neurometabolic coupling (Melrose et al., 2009), and reduced levels and activity of the endothelial glucose transporter 1 (GLUT-1) that delivers glucose to the brain from the blood (Kalaria and Harik, 1989; Simpson et al., 1994).

Gene_expression (levels) of GLUT-1 in cingulate cortex associated with disease

20) Confidence 0.09 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.89 Pain Relevance 0.21

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