INT55291

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Context Info
Confidence 0.68
First Reported 1994
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 11.46
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc2a1) transmembrane transporter activity (Slc2a1) plasma membrane (Slc2a1)
intracellular (Slc2a1) transmembrane transport (Slc2a1) cytoplasm (Slc2a1)
Anatomy Link Frequency
endothelial cells 5
spinal cords 2
body 2
plasma 1
lymph node 1
Slc2a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 377 99.84 Very High Very High Very High
anesthesia 41 99.52 Very High Very High Very High
Inflammation 89 98.88 Very High Very High Very High
medulla 36 92.40 High High
Central nervous system 107 91.32 High High
imagery 125 90.48 High High
withdrawal 1 88.08 High High
chemokine 3 83.40 Quite High
cytokine 53 82.80 Quite High
midbrain 13 63.88 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 186 99.88 Very High Very High Very High
Cancer 179 99.58 Very High Very High Very High
Disease 619 99.00 Very High Very High Very High
INFLAMMATION 105 98.88 Very High Very High Very High
Breast Cancer 136 98.86 Very High Very High Very High
Cerebral Edema 27 97.04 Very High Very High Very High
Necrosis 9 96.36 Very High Very High Very High
Motor Neuron Diseases 327 95.36 Very High Very High Very High
Lobular Carcinoma 8 92.48 High High
Hypoxia 6 88.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Strikingly, however, overexpression of GLUT-1 in muscle induced a profound reduction in insulin-stimulated whole body glucose disposal.
Gene_expression (overexpression) of GLUT-1 in body
1) Confidence 0.68 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7977725 Disease Relevance 0.35 Pain Relevance 0.06
Fasted mice overexpressing GLUT-1 in skeletal muscle exhibited a GIR that was only 54% that of controls (19.3 +/- 1.8 vs. 36.0 +/- 3.9 mg.kg-1.min-1) when blood glucose was clamped at euglycemic values.
Gene_expression (overexpressing) of GLUT-1 in blood
2) Confidence 0.68 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7977725 Disease Relevance 0.38 Pain Relevance 0.10
The effect of glucose transporter expression on insulin-stimulated whole body glucose disposal was examined in transgenic mice overexpressing GLUT-1 or GLUT-4.
Spec (examined) Gene_expression (overexpressing) of GLUT-1 in body associated with targeted disruption
3) Confidence 0.68 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7977725 Disease Relevance 0.27 Pain Relevance 0.09
Differential effects of GLUT-1 or GLUT-4 overexpression on insulin responsiveness in transgenic mice.
Gene_expression (overexpression) of GLUT-1 associated with targeted disruption and anesthesia
4) Confidence 0.68 Published 1994 Journal Am. J. Physiol. Section Title Doc Link 7977725 Disease Relevance 0.41 Pain Relevance 0.19
This downregulation of Glut-1 expression in the endothelial cells of the BSCB may be related to altered endothelial lining leading to vascular leakage.
Gene_expression (expression) of Glut-1 in endothelial cells
5) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.49 Pain Relevance 0.03
Downregulation of Glut-1 and CD146 expressions in spinal cord endothelial cells was also found in G93A mice at early and late stage disease and may relate to altered endothelial lining leading to vascular leakage.
Gene_expression (expressions) of Glut-1 in endothelial cells associated with disease and spinal cord
6) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 1.24 Pain Relevance 0.15
In the present study, we found low and mostly absent expression of Glut-1 in capillaries of both cervical and lumbar spinal cords of G93A mice at early and late stages of disease.
Neg (absent) Gene_expression (expression) of Glut-1 in spinal cords associated with disease
7) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.46 Pain Relevance 0.03
Although additional experiments such as quantitative analysis of Glut-1 distribution and density in the endothelial plasma membranes are needed to elucidate the regulatory mechanisms of Glut-1 expression in the spinal cord, the present study indicates that alteration of Glut-1 could be involved in the pathogenesis of ALS.
Gene_expression (expression) of Glut-1 in spinal cord associated with motor neuron diseases and spinal cord
8) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.54 Pain Relevance 0.08
Alternatively, decreased Glut-1 expression may result from aggravated alterations of the BSCB in G93A mice.
Gene_expression (expression) of Glut-1
9) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.52 Pain Relevance 0.04
Glut-1 expression was increased in WT and eNOS KO mice.
Gene_expression (expression) of Glut-1
10) Confidence 0.45 Published 2006 Journal Acad Emerg Med Section Body Doc Link 16551773 Disease Relevance 0.07 Pain Relevance 0
Additionally, downregulation of Glut-1 and CD146 expressions in the endothelial cells of the BSCB may be related to altered endothelial lining leading to vascular leakage.
Gene_expression (expressions) of Glut-1 in endothelial cells
11) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.68 Pain Relevance 0.11
Additionally, downregulation of Glut-1 and CD146 expressions in the endothelial cells of the BSCB were found which may relate to vascular leakage.


Gene_expression (expressions) of Glut-1 in endothelial cells
12) Confidence 0.44 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2075163 Disease Relevance 0.28 Pain Relevance 0.08
In search for the signs of BBB damage in the brain of symptomatic A53T mice, we examined the expression and subcellular distribution of aquaporin 4, glucose transporter 1 (Glut1) and von Willebrand factor (vWF) in astrocyte and vascular endothelial cells.
Spec (examined) Gene_expression (expression) of Glut1 in endothelial cells associated with targeted disruption
13) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0.45 Pain Relevance 0.26
50, Chemicon), rabbit anti-mouse Glut-1 polyclonal antibody (1?
Gene_expression (antibody) of Glut-1
14) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0 Pain Relevance 0.13
Immunofluorescent staining for Glut-1 (glucose transporter 1) showed high expression of Glut-1 in microvascular endothelia of the cervical and lumbar ventral horn of the spinal cords in C57BL/6J mice at 12–13 weeks of age (Figure 8A, B, H, I) and at 19–20 weeks of age (Figure 8C, J).
Gene_expression (expression) of Glut-1 in horn
15) Confidence 0.39 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.35 Pain Relevance 0.09
The expression of GLUT4 or GLUT1 was not modified by chronic treatment with IL-6 (Fig. 2E).
Gene_expression (expression) of GLUT1
16) Confidence 0.38 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.14 Pain Relevance 0.04
Cells were submitted to subcellular fractionation for plasma membrane and internal membrane isolation before immunoblotting with GLUT4, GLUT1, and caveolin-1 antibodies (8).
Gene_expression (antibodies) of GLUT1 in plasma
17) Confidence 0.33 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0 Pain Relevance 0.03
In the brain, GLUT1, GLUT2 and GLUT5 are expressed predominantly in a cell-specific manner [56-58].
Gene_expression (expressed) of GLUT1 in brain
18) Confidence 0.17 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0 Pain Relevance 0.11
Notable findings for irradiated tumors as compared to control tumors were high levels of Glut-1 expression (13 of 15 tumors), HK II (9 of 16 tumors), and Ki-67 expression (12 of 13 tumors).
Gene_expression (expression) of Glut-1 associated with cancer
19) Confidence 0.14 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 1.50 Pain Relevance 0.03
AD patients also characteristically feature a decrease in basal cerebral glucose utilization (CGU) in parietotemporal and posterior cingulate cortex (Fukuyama et al., 1994; Mosconi et al., 2004; Langbaum et al., 2009), altered neurometabolic coupling (Melrose et al., 2009), and reduced levels and activity of the endothelial glucose transporter 1 (GLUT-1) that delivers glucose to the brain from the blood (Kalaria and Harik, 1989; Simpson et al., 1994).
Gene_expression (levels) of GLUT-1 in cingulate cortex associated with disease
20) Confidence 0.09 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.89 Pain Relevance 0.21

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