INT55292

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Context Info
Confidence 0.61
First Reported 1994
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.98
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc2a1) transmembrane transporter activity (Slc2a1) plasma membrane (Slc2a1)
intracellular (Slc2a1) transmembrane transport (Slc2a1) cytoplasm (Slc2a1)
Anatomy Link Frequency
body 4
blood 2
Slc2a1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 10 99.52 Very High Very High Very High
positron emission tomography 24 60.48 Quite High
Paracetamol 6 50.00 Quite Low
Inflammation 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 20 99.88 Very High Very High Very High
Cancer 100 99.78 Very High Very High Very High
Necrosis 3 96.76 Very High Very High Very High
Toxicity 4 68.72 Quite High
Injury 1 50.00 Quite Low
Squamous Cell Neoplasms 1 50.00 Quite Low
Head & Neck Cancer 4 48.88 Quite Low
Squamous Cell Carcinoma 2 8.40 Low Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Metastasis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential effects of GLUT-1 or GLUT-4 overexpression on insulin responsiveness in transgenic mice.
Positive_regulation (overexpression) of Gene_expression (overexpression) of GLUT-1 associated with targeted disruption and anesthesia
1) Confidence 0.61 Published 1994 Journal Am. J. Physiol. Section Title Doc Link 7977725 Disease Relevance 0.41 Pain Relevance 0.19
Fasted mice overexpressing GLUT-1 in skeletal muscle exhibited a GIR that was only 54% that of controls (19.3 +/- 1.8 vs. 36.0 +/- 3.9 mg.kg-1.min-1) when blood glucose was clamped at euglycemic values.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of GLUT-1 in blood
2) Confidence 0.61 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7977725 Disease Relevance 0.38 Pain Relevance 0.10
Strikingly, however, overexpression of GLUT-1 in muscle induced a profound reduction in insulin-stimulated whole body glucose disposal.
Positive_regulation (overexpression) of Gene_expression (overexpression) of GLUT-1 in body
3) Confidence 0.61 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7977725 Disease Relevance 0.35 Pain Relevance 0.06
The effect of glucose transporter expression on insulin-stimulated whole body glucose disposal was examined in transgenic mice overexpressing GLUT-1 or GLUT-4.
Spec (examined) Positive_regulation (overexpressing) of Spec (examined) Gene_expression (overexpressing) of GLUT-1 in body associated with targeted disruption
4) Confidence 0.44 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7977725 Disease Relevance 0.27 Pain Relevance 0.09
Glut-1 expression was increased in WT and eNOS KO mice.
Positive_regulation (increased) of Gene_expression (expression) of Glut-1
5) Confidence 0.40 Published 2006 Journal Acad Emerg Med Section Body Doc Link 16551773 Disease Relevance 0.07 Pain Relevance 0
Notable findings for irradiated tumors as compared to control tumors were high levels of Glut-1 expression (13 of 15 tumors), HK II (9 of 16 tumors), and Ki-67 expression (12 of 13 tumors).
Positive_regulation (levels) of Gene_expression (expression) of Glut-1 associated with cancer
6) Confidence 0.11 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 1.50 Pain Relevance 0.03

General Comments

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