INT55292

Context Info Confidence 0.61 First Reported 1994 Last Reported 2007 Negated 0 Speculated 1 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 2.98 Pain Relevance 0.46

transport (Slc2a1) transmembrane transporter activity (Slc2a1) plasma membrane (Slc2a1) intracellular (Slc2a1) transmembrane transport (Slc2a1) cytoplasm (Slc2a1)

Anatomy Link Frequency body 4 blood 2 Slc2a1 (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 10 99.52 positron emission tomography 24 60.48 Paracetamol 6 50.00 Inflammation 5 5.00 imagery 5 5.00 ketamine 1 5.00 fibrosis 1 5.00 isoflurane 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 20 99.88 Cancer 100 99.78 Necrosis 3 96.76 Toxicity 4 68.72 Injury 1 50.00 Squamous Cell Neoplasms 1 50.00 Head & Neck Cancer 4 48.88 Squamous Cell Carcinoma 2 8.40 INFLAMMATION 5 5.00 Metastasis 2 5.00

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Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Differential effects of GLUT-1 or GLUT-4 overexpression on insulin responsiveness in transgenic mice.

Positive_regulation (overexpression) of Gene_expression (overexpression) of GLUT-1 associated with targeted disruption and anesthesia

1) Confidence 0.61 Published 1994 Journal Am. J. Physiol. Section Title Doc Link 7977725 Disease Relevance 0.41 Pain Relevance 0.19

Fasted mice overexpressing GLUT-1 in skeletal muscle exhibited a GIR that was only 54% that of controls (19.3 +/- 1.8 vs. 36.0 +/- 3.9 mg.kg-1.min-1) when blood glucose was clamped at euglycemic values.

Positive_regulation (overexpressing) of Gene_expression (overexpressing) of GLUT-1 in blood

2) Confidence 0.61 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7977725 Disease Relevance 0.38 Pain Relevance 0.10

Strikingly, however, overexpression of GLUT-1 in muscle induced a profound reduction in insulin-stimulated whole body glucose disposal.

Positive_regulation (overexpression) of Gene_expression (overexpression) of GLUT-1 in body

3) Confidence 0.61 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7977725 Disease Relevance 0.35 Pain Relevance 0.06

The effect of glucose transporter expression on insulin-stimulated whole body glucose disposal was examined in transgenic mice overexpressing GLUT-1 or GLUT-4.

Spec (examined) Positive_regulation (overexpressing) of Spec (examined) Gene_expression (overexpressing) of GLUT-1 in body associated with targeted disruption

4) Confidence 0.44 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7977725 Disease Relevance 0.27 Pain Relevance 0.09

Glut-1 expression was increased in WT and eNOS KO mice.

Positive_regulation (increased) of Gene_expression (expression) of Glut-1

5) Confidence 0.40 Published 2006 Journal Acad Emerg Med Section Body Doc Link 16551773 Disease Relevance 0.07 Pain Relevance 0

Notable findings for irradiated tumors as compared to control tumors were high levels of Glut-1 expression (13 of 15 tumors), HK II (9 of 16 tumors), and Ki-67 expression (12 of 13 tumors).

Positive_regulation (levels) of Gene_expression (expression) of Glut-1 associated with cancer

6) Confidence 0.11 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 1.50 Pain Relevance 0.03

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