INT55294

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Context Info
Confidence 0.70
First Reported 1994
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 17
Total Number 22
Disease Relevance 6.84
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Slc2a4) transport (Slc2a4) transmembrane transporter activity (Slc2a4)
plasma membrane (Slc2a4) transmembrane transport (Slc2a4) cytoplasm (Slc2a4)
Anatomy Link Frequency
muscle 2
skeletal muscle 2
plasma 1
fat 1
pituitary 1
Slc2a4 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 27 99.32 Very High Very High Very High
tolerance 87 98.88 Very High Very High Very High
Hippocampus 10 93.60 High High
cerebral cortex 3 92.24 High High
Inflammatory response 7 82.40 Quite High
cytokine 55 77.48 Quite High
alcohol 48 75.00 Quite High
Immobilon 2 63.36 Quite High
ischemia 16 52.20 Quite High
Central nervous system 14 43.88 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 80 99.88 Very High Very High Very High
Impaired Glucose Tolerance 94 98.88 Very High Very High Very High
Diabetes Mellitus 216 98.68 Very High Very High Very High
Obesity 148 98.64 Very High Very High Very High
Insulin Resistance 184 98.16 Very High Very High Very High
Arrhythmia Under Development 2 97.58 Very High Very High Very High
Disorder Of Lipid Metabolism 57 94.52 High High
Disease 129 90.68 High High
Hyperglycemia 73 89.52 High High
Muscle Disease 1 87.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, fasted mice overexpressing GLUT-4 in fat and muscle exhibited a GIR that was 40% higher than controls (53.9 +/- 2.3 vs. 39.1 +/- 2.5 mg.kg-1.min-1).
Gene_expression (overexpressing) of GLUT-4 in fat
1) Confidence 0.70 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7977725 Disease Relevance 0.39 Pain Relevance 0.09
The effect of glucose transporter expression on insulin-stimulated whole body glucose disposal was examined in transgenic mice overexpressing GLUT-1 or GLUT-4.
Spec (examined) Gene_expression (overexpressing) of GLUT-4 in body associated with targeted disruption
2) Confidence 0.70 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7977725 Disease Relevance 0.27 Pain Relevance 0.09
Differential effects of GLUT-1 or GLUT-4 overexpression on insulin responsiveness in transgenic mice.
Gene_expression (overexpression) of GLUT-4 associated with targeted disruption and anesthesia
3) Confidence 0.70 Published 1994 Journal Am. J. Physiol. Section Title Doc Link 7977725 Disease Relevance 0.41 Pain Relevance 0.19
Insulin responsiveness was enhanced by overexpression of GLUT-4.
Gene_expression (overexpression) of GLUT-4
4) Confidence 0.70 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7977725 Disease Relevance 0.36 Pain Relevance 0.06
Neither acute ethanol challenge nor ADH transgene affected expression of Glut4 (Fig. 6).


Gene_expression (expression) of Glut4
5) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.07 Pain Relevance 0.04
expression or unchanged Glut4 levels does not seem to favor an involvement of mitochondrial biogenesis and Gut4 in the ADH-exacerbated myocardial defect following acute ethanol challenge.
Gene_expression (expression) of Glut4
6) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.08 Pain Relevance 0
Although long-term ethanol exposure is known to inhibit Glut4 expression via an AMPK-dependent pathway in adipocytes [29], our current data were unable to address the intimate interplay among AMPK signaling, insulin sensitivity, myocardial and intracellular Ca2+ derangement following acute ethanol exposure.
Gene_expression (expression) of Glut4 in adipocytes associated with obesity
7) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.15 Pain Relevance 0
has a suppressive role on glucose transporter 4 (GLUT4) expression in skeletal muscle [8],[37].
Gene_expression (expression) of GLUT4 in skeletal muscle
8) Confidence 0.45 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.28 Pain Relevance 0.05
The expression of GLUT4 or GLUT1 was not modified by chronic treatment with IL-6 (Fig. 2E).
Gene_expression (expression) of GLUT4
9) Confidence 0.44 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.14 Pain Relevance 0.04
PIP3 and GLUT4 expressions were analyzed by immunohistochemistry in the same manner as described previously [28].
Spec (analyzed) Gene_expression (expressions) of GLUT4
10) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.06 Pain Relevance 0
We disclosed that berberine could upregulate the expression of 2 genes related to MAPK (mitogen-activated protein kinase) pathway and GLUT4.
Gene_expression (expression) of GLUT4
11) Confidence 0.44 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.42 Pain Relevance 0
, decreased insulin receptor expression as well as unchanged expression of Glut4, the response of which was unaffected by ADH.
Gene_expression (expression) of Glut4
12) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890411 Disease Relevance 0.43 Pain Relevance 0.13
Moreover, insulin induces glucose transporter 4 (GLUT4) expression and its translocation, which facilitates glucose uptake into cells [38].
Gene_expression (expression) of glucose transporter 4
13) Confidence 0.40 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.46 Pain Relevance 0.03
Moreover, insulin induces glucose transporter 4 (GLUT4) expression and its translocation, which facilitates glucose uptake into cells [38].
Gene_expression (expression) of GLUT4
14) Confidence 0.40 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.45 Pain Relevance 0.03
RT2 profiler PCR array analysis showed that berberine
                 upregulated the expression of glucose transporter 4 (GLUT4), mitogen-activated protein kinase 14 (MAPK14), 
                 MAPK8(c-jun N-terminal kinase, JNK), peroxisome proliferator-activated receptor ? 
Gene_expression (expression) of glucose transporter 4
15) Confidence 0.39 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2952334 Disease Relevance 0.40 Pain Relevance 0.04
RT2 profiler PCR array analysis showed that berberine
                 upregulated the expression of glucose transporter 4 (GLUT4), mitogen-activated protein kinase 14 (MAPK14), 
                 MAPK8(c-jun N-terminal kinase, JNK), peroxisome proliferator-activated receptor ? 
Gene_expression (expression) of GLUT4
16) Confidence 0.39 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2952334 Disease Relevance 0.40 Pain Relevance 0.04
Also, glucose transporter 4 (GLUT4) gene expression, which is involved in glucose transport in membranes, was upregulated by 4.48-fold in the berberine group.
Gene_expression (expression) of GLUT4
17) Confidence 0.39 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.06 Pain Relevance 0
Cells were submitted to subcellular fractionation for plasma membrane and internal membrane isolation before immunoblotting with GLUT4, GLUT1, and caveolin-1 antibodies (8).
Gene_expression (antibodies) of GLUT4 in plasma
18) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0 Pain Relevance 0.03
In contrast, fasted mice overexpressing GLUT-4 in fat and muscle exhibited a GIR that was 40% higher than controls (53.9 +/- 2.3 vs. 39.1 +/- 2.5 mg.kg-1.min-1).
Gene_expression (overexpressing) of GLUT-4 in muscle
19) Confidence 0.24 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7977725 Disease Relevance 0.39 Pain Relevance 0.09
GLUT4 is also found in the pituitary and the hypothalamus.
Gene_expression (found) of GLUT4 in pituitary
20) Confidence 0.14 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.08 Pain Relevance 0.13

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