INT55305

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Context Info
Confidence 0.45
First Reported 1993
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 5.27
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (RYR1) transmembrane transport (RYR1) cytoplasm (RYR1)
Anatomy Link Frequency
reticulum 3
muscles 1
pore 1
skeletal muscle 1
CCO 1
RYR1 (Homo sapiens)
RYR1 - G4898R (1)
Pain Link Frequency Relevance Heat
local anesthetic 9 100.00 Very High Very High Very High
Calcium channel 14 99.84 Very High Very High Very High
adenocard 9 99.52 Very High Very High Very High
antagonist 7 99.26 Very High Very High Very High
peptic ulcer disease 1 95.16 Very High Very High Very High
analgesia 1 87.08 High High
sodium channel 17 84.16 Quite High
Central nervous system 3 83.60 Quite High
halothane 46 82.80 Quite High
lidocaine 3 64.24 Quite High
Disease Link Frequency Relevance Heat
Malignant Hyperthermia 520 99.58 Very High Very High Very High
Hypertension 48 99.28 Very High Very High Very High
Stress 36 98.84 Very High Very High Very High
Toxicity 8 96.80 Very High Very High Very High
Fatigue 3 96.08 Very High Very High Very High
Borrelia Infection 3 95.72 Very High Very High Very High
Disease 34 95.16 Very High Very High Very High
Ulcers 1 94.84 High High
Cardiovascular Disease 1 94.28 High High
Cancer 1 93.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although mutations in the ryanodine receptor are undoubtedly important in the pathophysiology of MH, it is also clear that not all families demonstrate linkage to this gene.
Regulation (important) of ryanodine receptor associated with malignant hyperthermia
1) Confidence 0.45 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 0.87 Pain Relevance 0.14
A number of functional tests have been used successfully to assess the role of RYR1 mutations in calcium release.
Regulation (role) of RYR1
2) Confidence 0.45 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 0.18 Pain Relevance 0
Model of the RyR1 pore region
Regulation (Model) of RyR1 in pore
3) Confidence 0.29 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2668181 Disease Relevance 0 Pain Relevance 0
In contrast, addition of 10 mM trans Ca2+ did not generate a noticeable unitary Ca2+ current at 0 mV, and had no effect on ion currents or reversal potential of RyR1-G4898R.
Neg (no) Regulation (effect) of RyR1-G4898R (G4898R)
4) Confidence 0.29 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2668181 Disease Relevance 0.08 Pain Relevance 0.03
In some MH families, a genetic alteration of the ryanodine receptor gene (a calcium channel of the sarcoplasmic reticulum) on chromosome 19 has been identified as the potential cause of MH susceptibility.
Regulation (alteration) of ryanodine receptor gene in reticulum associated with calcium channel and malignant hyperthermia
5) Confidence 0.26 Published 1994 Journal Anaesthesist Section Abstract Doc Link 7978181 Disease Relevance 1.10 Pain Relevance 0.09
At the cellular level, caffeine is a competitive antagonist of adenosine receptors and probably acts directly on the ryanodine receptor (Ca++ release channel) to potentiate Ca++ release from skeletal muscle sarcoplasmic reticulum.
Regulation (acts) of ryanodine receptor in reticulum associated with adenocard and antagonist
6) Confidence 0.26 Published 1994 Journal Sports Med Section Abstract Doc Link 9132918 Disease Relevance 0.64 Pain Relevance 0.24
IVCT demonstrated an MHS response and a "causative" mutation.
Regulation (response) of MHS
7) Confidence 0.24 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 1.38 Pain Relevance 0.17
The ryanodine receptor (RyR) is one target for caffeine.
Regulation (target) of RyR
8) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2525814 Disease Relevance 0 Pain Relevance 0
The ryanodine receptor (RyR) is one target for caffeine.
Regulation (target) of ryanodine receptor
9) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2525814 Disease Relevance 0 Pain Relevance 0
METHODS: The authors studied the effects of bupivacaine and the similarly lipid-soluble local anesthetic, tetracaine, on the Ca2+ release channel-ryanodine receptor of sarcoplasmic reticulum in swine skeletal and cardiac muscle. [3H]Ryanodine binding was used to measure the activity of the Ca2+ release channel-ryanodine receptors in microsomes of both muscles.
Regulation (effects) of channel-ryanodine receptor in muscles
10) Confidence 0.07 Published 1999 Journal Anesthesiology Section Body Doc Link 10078686 Disease Relevance 0.19 Pain Relevance 0
The effects of various local anesthetics (LAs) on the skeletal muscle ryanodine receptor were tested.
Regulation (effects) of ryanodine receptor in skeletal muscle associated with local anesthetic
11) Confidence 0.07 Published 1993 Journal J. Membr. Biol. Section Abstract Doc Link 8390576 Disease Relevance 0 Pain Relevance 0.49
Thus, the pronounced myotoxicity of bupivacaine may be the result of this specific effect on Ca2+ release channel-ryanodine receptor superimposed on a nonspecific action on lipid bilayers to increase the Ca2+ permeability of sarcoplasmic reticulum membranes, an effect shared by all local anesthetics.
Regulation (effect) of channel-ryanodine receptor in reticulum
12) Confidence 0.04 Published 1999 Journal Anesthesiology Section Body Doc Link 10078686 Disease Relevance 0.10 Pain Relevance 0
ASImed, MAP-MHS, MAP-PHS, EQ-VAS, and EQ-5D were all responsive to decreases in illicit drug use.
Regulation (responsive) of MAP-MHS
13) Confidence 0.01 Published 2010 Journal J Clin Epidemiol Section Body Doc Link 20236799 Disease Relevance 0 Pain Relevance 0
Further, the level of agreement between these CCO values and COTCP during IAH was determined.
Regulation (values) of CCO in CCO associated with hypertension
14) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2592771 Disease Relevance 0.56 Pain Relevance 0.03
The observed stereoselectivity suggests effects on specific proteins, the ryanodine Ry1 receptor and the Ca2+-ATPase pump, rather than non-specific increase in Ca2+ permeability.
Regulation (effects) of ryanodine Ry1 receptor
15) Confidence 0.01 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15840391 Disease Relevance 0 Pain Relevance 0.06
In addition, a similar approach has previously been used to determine fluid responsiveness of SVVPiCCO [10], and we previously observed a similar haemodynamic pattern and comparable threshold value for SVVPiCCO in a true fluid challenge [3].
Spec (determine) Regulation (responsiveness) of SVVPiCCO
16) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2481481 Disease Relevance 0.17 Pain Relevance 0.09

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