INT55309

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Context Info
Confidence 0.46
First Reported 1993
Last Reported 2009
Negated 4
Speculated 1
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 5.97
Pain Relevance 5.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ssr1)
Anatomy Link Frequency
spinal 2
sympathetic 2
finger 1
internal 1
thoracic 1
Ssr1 (Mus musculus)
Pain Link Frequency Relevance Heat
b2 receptor 2 100.00 Very High Very High Very High
antagonist 12 99.72 Very High Very High Very High
opioid receptor 5 99.48 Very High Very High Very High
transcutaneous nerve stimulation 15 98.32 Very High Very High Very High
Central nervous system 6 98.24 Very High Very High Very High
qutenza 1 97.86 Very High Very High Very High
Pain 26 97.52 Very High Very High Very High
analgesia 17 96.68 Very High Very High Very High
Acupuncture 65 96.28 Very High Very High Very High
Rsd 2 96.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Frailty 4 99.60 Very High Very High Very High
Syndrome 26 99.24 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 98.36 Very High Very High Very High
Paraplegia 5 98.02 Very High Very High Very High
Quadriplegia 6 97.74 Very High Very High Very High
Pain 19 97.52 Very High Very High Very High
Adult Respiratory Distress Syndrome 10 97.28 Very High Very High Very High
Neuropathy 59 97.00 Very High Very High Very High
Complex Regional Pain Syndromes 2 96.24 Very High Very High Very High
Nociception 7 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The SSR is mediated at spinal and supraspinal sites within the central nervous system (CNS), and may, in part, represent a nociceptive response.
Positive_regulation (mediated) of SSR in spinal associated with nociception and central nervous system
1) Confidence 0.46 Published 1994 Journal Anesth. Analg. Section Abstract Doc Link 7978418 Disease Relevance 0.10 Pain Relevance 0.24
SSR are generated through a complex somato-sympathetic reflex with spinal, bulbar and suprabulbar components [13].
Positive_regulation (generated) of SSR in spinal
2) Confidence 0.43 Published 2006 Journal Clin Auton Res Section Body Doc Link PMC1705534 Disease Relevance 0 Pain Relevance 0.08
Although measuring SSR is relatively simple, interpreting these measurements is not so straightforward.
Positive_regulation (measuring) of SSR
3) Confidence 0.40 Published 2006 Journal Clin Auton Res Section Body Doc Link PMC1705534 Disease Relevance 0.16 Pain Relevance 0.09
However, patients with cervical or high thoracic lesions resulting in complete tetraplegia or paraplegia have no SSR from the hands and feet [6], suggesting that supraspinal centers are essential in the generation of SSR.
Positive_regulation (generation) of SSR in thoracic associated with paraplegia and quadriplegia
4) Confidence 0.40 Published 2006 Journal Clin Auton Res Section Body Doc Link PMC1705534 Disease Relevance 0.20 Pain Relevance 0.14
Sympathetic skin response (SSR) was also no longer induced on the gel-treated middle finger in 1 of another 3 subjects and was severely depressed in the other 2 subjects, while the SSR on the untreated index finger appeared constantly.
Neg (no) Positive_regulation (induced) of SSR in finger
5) Confidence 0.39 Published 1993 Journal J Anesth Section Abstract Doc Link 15278491 Disease Relevance 0.07 Pain Relevance 0.27
In addition, electrically induced sympathetic skin response (SSR) was assessed in the palms and soles.
Positive_regulation (induced) of SSR in skin
6) Confidence 0.39 Published 2007 Journal Auton Neurosci Section Abstract Doc Link 17561445 Disease Relevance 0.51 Pain Relevance 0.30
A variety of stimuli can generate a SSR, which illustrates the complexity of the afferent inputs to the reflex.
Positive_regulation (generate) of SSR
7) Confidence 0.37 Published 2006 Journal Clin Auton Res Section Body Doc Link PMC1705534 Disease Relevance 0.15 Pain Relevance 0.10
For example, electrical pulses over the sternal skin can be used to elicit SSR in the palms [19], which highlight the complexity of the internal neuronal network involving polysynaptic relays and connections between different vertical levels along the neuraxis and in both sides of the human body [11].
Positive_regulation (elicit) of SSR in internal
8) Confidence 0.37 Published 2006 Journal Clin Auton Res Section Body Doc Link PMC1705534 Disease Relevance 0 Pain Relevance 0.09
Four patients who had a primary respiratory diagnosis were unable to maintain SSR at the time of admission.
Neg (unable) Positive_regulation (maintain) of SSR in respiratory
9) Confidence 0.32 Published 2003 Journal BMC Pulm Med Section Body Doc Link PMC305355 Disease Relevance 0.62 Pain Relevance 0
When data was combined for both groups of patients a positive SSR status correctly predicted weaning outcome in 84% of patients with acute lung injury, 72% of patients with a neurologic event, 80% of patients with obstructive lung disease, 100% of post-operative patients and 71% of patients admitted with another diagnosis such as trauma.
Positive_regulation (positive) of SSR in lung associated with obstructive airway disease, injury and adult respiratory distress syndrome
10) Confidence 0.32 Published 2003 Journal BMC Pulm Med Section Body Doc Link PMC305355 Disease Relevance 0.41 Pain Relevance 0
This long time series has enabled us to report on the reciprocal importance of KNP and SSR to the elephant and its attendant herd and that since the fence between the two reserves was dropped, the elephants consistently rely upon KNP for summer grazing and SSR for winter grazing and water.
Positive_regulation (importance) of SSR
11) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2587706 Disease Relevance 0 Pain Relevance 0
The fence between KNP and SSR was dropped in 1993 after which elephant numbers in SSR increased rapidly from 60 to 1,398 (2.15/km2) by 2007, an average annual increase of 13.8%.
Positive_regulation (increased) of SSR
12) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2587706 Disease Relevance 0.08 Pain Relevance 0
Increasing evidence has suggested that both sympathetic activity and stimulation-induced SSR are differentially controlled in an organ-specific and activity-dependent manner.
Positive_regulation (induced) of SSR in sympathetic
13) Confidence 0.17 Published 2009 Journal Chin J Physiol Section Abstract Doc Link 20359125 Disease Relevance 0.42 Pain Relevance 1.13
However, it has been shown that SSR can be elicited in any healthy subject [14].
Positive_regulation (elicited) of SSR
14) Confidence 0.16 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577935 Disease Relevance 0.06 Pain Relevance 0.03
TENS applied at AG and NSG caused a significant increase in ST (P = 0.001), significant increase in latency of SSR (P = 0.001), significant decrease in amplitude of SSR (P = 0.001) and no significant changes were observed in duration of SSR (P > 0.05).
Positive_regulation (increase) of SSR associated with transcutaneous nerve stimulation
15) Confidence 0.16 Published 2004 Journal Electromyogr Clin Neurophysiol Section Abstract Doc Link 15008021 Disease Relevance 0 Pain Relevance 1.12
The interface also supplies acoustical (1 kHz, 0-100 dB, duration 10-1000ms) and electrical outputs (square wave pulse, 0-30mA, 0.2 ms duration) for triggering the SSR.
Positive_regulation (triggering) of SSR
16) Confidence 0.14 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577935 Disease Relevance 0 Pain Relevance 0
SSR could not be elicited in 5 / 22 Parkinson patients, but none of them had “pathological HRV”.


Neg (not) Positive_regulation (elicited) of SSR
17) Confidence 0.14 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577935 Disease Relevance 0.37 Pain Relevance 0
Therefore, SSR is a test method that might facilitate differential diagnosis of HSAN III and IV.
Spec (might) Positive_regulation (facilitate) of SSR
18) Confidence 0.08 Published 1999 Journal Neurology Section Body Doc Link 10331694 Disease Relevance 0.16 Pain Relevance 0
We conclude that a SHS complicating CSCI is associated with increased amplitude of the SSR, supporting the theory that sympathetic hyperactivity is important in the pathophysiology of reflex sympathetic dystrophy in this setting.
Positive_regulation (increased) of SSR in sympathetic associated with rsd, syndrome, frailty and attention deficit hyperactivity disorder
19) Confidence 0.04 Published 1995 Journal Paraplegia Section Abstract Doc Link 8848315 Disease Relevance 1.65 Pain Relevance 0.48
These recent reports support the results from early studies using axonal tracing, functional assays and electrophysiology, which have demonstrated a somatosensory nerves–gracile nucleus–thalamic pathway which contributes to SSR activities (24–26,29,30).
Positive_regulation (contributes) of SSR in gracile nucleus
20) Confidence 0.03 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC442119 Disease Relevance 0.18 Pain Relevance 0.65

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