INT55315

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Context Info
Confidence 0.74
First Reported 1994
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 32
Total Number 35
Disease Relevance 14.60
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tbp) DNA binding (Tbp) transcription factor binding (Tbp)
cytoplasm (Tbp)
Anatomy Link Frequency
neuronal 2
apoptotic cells 2
spine 1
brains 1
cornea 1
Tbp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 109 98.48 Very High Very High Very High
cva 54 83.64 Quite High
Immobilon 2 82.56 Quite High
Pyramidal cell 21 79.36 Quite High
imagery 21 73.72 Quite High
cytokine 3 72.52 Quite High
depression 17 67.76 Quite High
abdominal pain 2 58.88 Quite High
agonist 22 57.32 Quite High
anesthesia 9 50.00 Quite Low
Disease Link Frequency Relevance Heat
Ataxia 34 100.00 Very High Very High Very High
Renal Failure 20 100.00 Very High Very High Very High
Tuberculous Peritonitis 18 100.00 Very High Very High Very High
Disease 163 99.76 Very High Very High Very High
Injury 43 99.54 Very High Very High Very High
Death 203 99.18 Very High Very High Very High
Keratitis 39 99.16 Very High Very High Very High
Alzheimer's Dementia 3 99.04 Very High Very High Very High
Apoptosis 273 98.84 Very High Very High Very High
Recurrence 2 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used anti-TBP antibody rather than the 1C2 antibody against polyQ as 1C2 antibody interacts with polyQ stretches in other transcription factors also and anti-TBP antibody recognizes TBP expressed from the endogenous gene as well as transfected gene.
Gene_expression (expressed) of TBP
1) Confidence 0.74 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.05 Pain Relevance 0
Besides, SCA17, caused by the expansion of polyQ tract in the TATA binding protein itself, normal TBP is also found in intra nuclear protein aggregates formed in other neurodegenerative diseases, notably, huntington's disease [8].
Gene_expression (expansion) of TATA binding protein associated with disease and neurodegenerative disease
2) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.71 Pain Relevance 0
In our studies the cells expressing 16Q TBP showed higher constant levels of cytosolic Cyt c compared to cells which express the vector alone. 59Q TBP cells, however, showed a significant difference in the cytochrome c release pattern.
Gene_expression (express) of TBP
3) Confidence 0.64 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.50 Pain Relevance 0
In our studies the cells expressing 16Q TBP showed higher constant levels of cytosolic Cyt c compared to cells which express the vector alone. 59Q TBP cells, however, showed a significant difference in the cytochrome c release pattern.
Gene_expression (expressing) of TBP
4) Confidence 0.64 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.39 Pain Relevance 0
Any indirect effect arising from differential transfection or expression of the transfected TBP in 16Q and 59Q constructs was ruled out by real-time PCR analysis and northern analysis of GFP transcript expressed in fusion with the transfected TBP alleles (Fig. 2B, Fig. 3A–C).
Gene_expression (expressed) of TBP
5) Confidence 0.64 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0 Pain Relevance 0
Besides, SCA17, caused by the expansion of polyQ tract in the TATA binding protein itself, normal TBP is also found in intra nuclear protein aggregates formed in other neurodegenerative diseases, notably, huntington's disease [8].
Gene_expression (expansion) of TBP associated with disease and neurodegenerative disease
6) Confidence 0.64 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.71 Pain Relevance 0
Alternatively, polyQ containing TBP can form heterodimers in solution with the endogenous functional TBP and alter its availability at various promoters.
Gene_expression (containing) of TBP
7) Confidence 0.64 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.30 Pain Relevance 0
We substantiated the model by cytological observation of large intranuclear aggregates only in cells transfected with TBP variants carrying expanded polyQ (Fig.
Gene_expression (transfected) of TBP
8) Confidence 0.64 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.45 Pain Relevance 0
Vdac1 overexpression, independently implicated in triggering cell death was one of the effects of polyglutamine expansion in TBP, identified in our study.
Gene_expression (expansion) of TBP associated with death
9) Confidence 0.64 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.60 Pain Relevance 0
Any indirect effect arising from differential transfection or expression of the transfected TBP in 16Q and 59Q constructs was ruled out by real-time PCR analysis and northern analysis of GFP transcript expressed in fusion with the transfected TBP alleles (Fig. 2B, Fig. 3A–C).
Gene_expression (expression) of TBP
10) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0 Pain Relevance 0
The cells expressing 59Q TBP showed a gradual increase in cytochrome c release resulting in substantially higher Cyt c levels at time points beyond 36 hours compared to cells which express the vector alone (Fig. 7B), in agreement with increased expression of VDAC1.
Gene_expression (expressing) of TBP
11) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.55 Pain Relevance 0
The situation in 59Q TBP transfected cells is likely to be totally different due to the apparent aggregation of a significant fraction of the transfected protein (Fig.
Gene_expression (transfected) of TBP
12) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0 Pain Relevance 0
The ratio of the spliced and unspliced variants of xbp1 showed no alteration in cells expressing the different polyQ TBP alleles (Fig. 5).
Gene_expression (expressing) of TBP
13) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.21 Pain Relevance 0
We found increased cytochrome c release and apoptotic cell death from the mitochondria in mouse neuronal cells expressing a variant of human TBP harboring abnormally expanded polyQ tract.
Gene_expression (expressing) of TBP in apoptotic cell associated with apoptosis and death
14) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.57 Pain Relevance 0
As shown in Fig 6, a specific antibody against VDAC1 was used to monitor the level of VDAC1 protein in cells transfected with a vector control, 16Q TBP or 59Q TBP.
Gene_expression (transfected) of TBP
15) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.35 Pain Relevance 0
We find that mouse neuronal cells expressing a variant of human TBP harboring an abnormally expanded polyQ tract not only form intranuclear aggregates, but also show transcription dysregulation of the voltage dependent anion channel, Vdac1, increased cytochrome c release from the mitochondria and upregulation of genes involved in localized neuronal translation.
Gene_expression (expressing) of TBP in neuronal
16) Confidence 0.50 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2064964 Disease Relevance 0.17 Pain Relevance 0
Mouse neuronal cells expressing a variant of human TBP harboring 59Q repeats were seen to accumulate intranuclear aggregates whereas a variant harbouring a 16Q stretch did not show any signs of aggregation.
Gene_expression (expressing) of TBP in neuronal
17) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.09 Pain Relevance 0
Concurrently, 59Q TBP expressing cells showed a 20% increase in number of apoptotic cells.
Gene_expression (expressing) of TBP in apoptotic cells associated with apoptosis
18) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.61 Pain Relevance 0
In this paper, we establish models of experimental corneal neovascularization (CorNV), fungal keratitis (FK) and corneal wound in mice and study the expression patterns of three traditional HKGs (ACTB, lactate dehydrogenase [LDHA], and GAPDH), five new HKGs (ubiquitin C [UBC] [14], peptidylprolyl isomerase A [PPIA] [15], TATA-box binding protein [TBP] [16], hypoxanthine guanine phosphoribosyl transferase [HPRT1] [17], and ribosomal protein L5 [RPL5] [18]).
Gene_expression (expression) of TATA-box binding protein associated with corneal neovascularization, injury and keratitis
19) Confidence 0.49 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2893048 Disease Relevance 0.40 Pain Relevance 0.04
Expression of 8 HKGs (glyceraldehyde-3-phosphate dehydrogenase [GAPDH], beta-actin [ACTB], lactate dehydrogenase A [LDHA], ribosomal protein L5 [RPL5], ubiquitin C [UBC], peptidylprolyl isomerase A [PPIA], TATA-box binding protein [TBP1], and hypoxanthine guanine phosphoribosyl transferase [HPRT1]) in the cornea were measured at various time points by microarray hybridization or qRT–PCR and the data analyzed using geNorm and NormFinder.


Spec (analyzed) Gene_expression (Expression) of TATA-box binding protein in cornea
20) Confidence 0.49 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2893048 Disease Relevance 0.84 Pain Relevance 0

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