INT5533

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Context Info
Confidence 0.48
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 43
Total Number 51
Disease Relevance 8.69
Pain Relevance 18.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
mammary gland 3
neurons 3
plasma 2
nucleus 2
amygdala 2
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 18 100.00 Very High Very High Very High
Opioid 25 99.98 Very High Very High Very High
opiate 5 99.98 Very High Very High Very High
antagonist 473 99.96 Very High Very High Very High
narcan 47 99.86 Very High Very High Very High
Pain threshold 11 99.84 Very High Very High Very High
Morphine 36 99.82 Very High Very High Very High
agonist 211 99.80 Very High Very High Very High
addiction 20 99.80 Very High Very High Very High
Serotonin 4 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 41 99.96 Very High Very High Very High
Eating Disorder 3 99.92 Very High Very High Very High
Pain 65 99.84 Very High Very High Very High
Morphine Dependence 4 99.80 Very High Very High Very High
Wound Healing 76 99.40 Very High Very High Very High
Congenital Anomalies 49 99.40 Very High Very High Very High
Diabetes Mellitus 32 99.24 Very High Very High Very High
Cognitive Disorder 29 98.90 Very High Very High Very High
Urological Neuroanatomy 52 98.76 Very High Very High Very High
Drug Dependence 2 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was undertaken to investigate the role of oxytocin in antinociception in the nucleus raphe magnus (NRM) of rats and the possible interaction between oxytocin and the opioid systems.
oxytocin Binding (interaction) of in nucleus associated with raphe magnus, antinociception and opioid
1) Confidence 0.48 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 14556956 Disease Relevance 0.09 Pain Relevance 0.91
We further show that estradiol-17beta alone rapidly modifies opioid interactions with oxytocin neurons, by recording their firing rate in anesthetized rats sensitized to naloxone by morphine dependence.
oxytocin Binding (interactions) of in neurons associated with addiction, narcan, opioid and morphine
2) Confidence 0.48 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 17960480 Disease Relevance 0.10 Pain Relevance 0.96
However, in mid-pregnancy the excitability of these neurons is reduced, central dendritic oxytocin release is inhibited and patterns of oxytocin receptor binding in the brain alter.
oxytocin Binding (binding) of in brain
3) Confidence 0.47 Published 2007 Journal Physiol. Behav. Section Abstract Doc Link 17512024 Disease Relevance 0.33 Pain Relevance 0.29
The effects of acute and chronic morphine administration and the interaction with oxytocin and vasopressin on food intake response were investigated at various intervals during a 24-h schedule in rats.
oxytocin Binding (interaction) of associated with morphine
4) Confidence 0.45 Published 1991 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1780342 Disease Relevance 0 Pain Relevance 0.34
Oxytocin/alpha(2)-Adrenoceptor interactions in feeding responses.
Oxytocin Binding (interactions) of
5) Confidence 0.44 Published 2000 Journal Neuroendocrinology Section Title Doc Link 10729792 Disease Relevance 0 Pain Relevance 0.40
These findings suggest the existence of an antagonistic oxytocin/alpha(2)-receptor interaction in the hypothalamus and amygdala that may be of relevance for the demonstrated modulation of alpha(2)-adrenoceptor-induced feeding responses by oxytocin.
oxytocin Binding (interaction) of in hypothalamus associated with amygdala
6) Confidence 0.44 Published 2000 Journal Neuroendocrinology Section Abstract Doc Link 10729792 Disease Relevance 0 Pain Relevance 0.42
The influence of treatment with oestradiol on the effects of the uterine relaxants, relaxin, salbutamol (an agonist at beta 2-adrenoceptors) and cromakalim (a potassium channel opener) and their interactions with the uterine stimulant oxytocin were investigated in vivo in the ovariectomized rat.
oxytocin Binding (interactions) of in uterine associated with agonist and potassium channel
7) Confidence 0.40 Published 1992 Journal J. Endocrinol. Section Abstract Doc Link 1431680 Disease Relevance 0.14 Pain Relevance 0.24
CONCLUSIONS: The reversal by oxytocin of the fluoxetine-induced deficit in ejaculations is consistent with the hypothesis that serotonin suppresses ejaculatory mechanisms by interrupting the action of oxytocin, which normally accompanies sexual behavior.
oxytocin Binding (interrupting) of
8) Confidence 0.37 Published 1999 Journal Psychopharmacology (Berl.) Section Body Doc Link 10435408 Disease Relevance 0.05 Pain Relevance 0
These differences in the pattern of response were not due to changes in density of oxytocin binding in the limbic areas studied, since autoradiographic detection of oxytocin binding sites using the iodinated antagonist [125I]d(CH2)5[Tyr(Me)2, Thr4, Orn3, Tyr-NH2(9)]-vasotocin showed no differences between the pregnant and postpartum animals.
oxytocin Binding (binding) of associated with antagonist
9) Confidence 0.36 Published 1997 Journal Neuroscience Section Abstract Doc Link 9300435 Disease Relevance 0 Pain Relevance 0.23
At present, our findings only indicate a causal link between our EE treatment, as well as oxytocin, and improved wound healing in isolation reared rats.
oxytocin Binding (link) of associated with wound healing
10) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677672 Disease Relevance 0.49 Pain Relevance 0.27
However, comparison of the binding of iodinated antagonist to plasma membranes from the lactating mammary gland with kidney medulla and liver, target sites for AVP, showed that binding was specific for the mammary gland and hence oxytocin receptors.
oxytocin Binding (binding) of in mammary gland associated with medulla and antagonist
11) Confidence 0.36 Published 1989 Journal Biochem. Cell Biol. Section Abstract Doc Link 2546575 Disease Relevance 0.07 Pain Relevance 0.36
These results are discussed in light of complex opiate-oxytocin/vasopressin interactions in the regulation of food intake.
oxytocin Binding (interactions) of associated with opiate
12) Confidence 0.35 Published 1991 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1780342 Disease Relevance 0.19 Pain Relevance 0.63
Interaction between myometrial relaxants and oxytocin: a comparison between relaxin, cromakalim and salbutamol.
oxytocin Binding (Interaction) of
13) Confidence 0.34 Published 1992 Journal J. Endocrinol. Section Title Doc Link 1431680 Disease Relevance 0.14 Pain Relevance 0.24
Pethidine (also known as meperidine and as Demerol) injected subcutaneously at 10 mg/kg into parturient rats on the birth of the second pup resulted in a marked slowing of the progress of parturition, associated with reduced plasma oxytocin concentrations.
oxytocin Binding (associated) of in plasma associated with algil
14) Confidence 0.32 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1877695 Disease Relevance 0 Pain Relevance 0.71
Endogenous opioid inhibition of oxytocin secretion increases in pregnancy, initially acting on the nerve terminals in the posterior pituitary and later on oxytocin cell bodies and their inputs.
oxytocin Binding (acting) of in posterior pituitary associated with endogenous opioid
15) Confidence 0.32 Published 2001 Journal Prog. Brain Res. Section Abstract Doc Link 11589146 Disease Relevance 0.14 Pain Relevance 0.34
Does acute, intense stimulation of oxytocin neurones in the supraoptic nucleus increase their content of oxytocin mRNA?
oxytocin Binding (content) of in supraoptic nucleus associated with narcan
16) Confidence 0.32 Published 1989 Journal Brain Res. Section Title Doc Link 2743158 Disease Relevance 0 Pain Relevance 0.33
If acupuncture is similarly effective in counteracting the effects of oxytocin in women, then this may an alternative medical treatment for women in preterm labor.
oxytocin Binding (counteracting) of associated with acupuncture and pre-term labor
17) Confidence 0.31 Published 2000 Journal Am. J. Chin. Med. Section Abstract Doc Link 10794115 Disease Relevance 0.60 Pain Relevance 0.86
Anorexia nervosa is associated with vasopressin, oxytocin and serotonin abnormalities.
oxytocin Binding (associated) of associated with congenital anomalies, serotonin and eating disorder
18) Confidence 0.30 Published 1993 Journal Brain Res. Section Abstract Doc Link 8101130 Disease Relevance 0.66 Pain Relevance 0.30
When incubated with purified plasma membranes from rat or human myometrial tissue, OPC-21268 inhibited the specific receptor binding of tritiated oxytocin and vasopressin in a dose-dependent and reversible way.
oxytocin Binding (binding) of in plasma
19) Confidence 0.30 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8566118 Disease Relevance 0.09 Pain Relevance 0.14
A more precise study of oxytocin binding using histo-autoradiography, especially regarding the rat amygdala, was undertaken by Veinante and Freund-Mercier in 1997 [31].
oxytocin Binding (binding) of in amygdala associated with amygdala
20) Confidence 0.29 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.11 Pain Relevance 0.16

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