INT55335

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Context Info
Confidence 0.34
First Reported 1994
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 49
Total Number 51
Disease Relevance 15.48
Pain Relevance 18.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
colon 2
platelet 2
macrophage 1
knee joints 1
central nervous system 1
Cpox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 84 100.00 Very High Very High Very High
opioid receptor 63 100.00 Very High Very High Very High
COX2 54 100.00 Very High Very High Very High
antagonist 40 100.00 Very High Very High Very High
aspirin 37 100.00 Very High Very High Very High
cOX1 23 100.00 Very High Very High Very High
Morphine 19 100.00 Very High Very High Very High
Opioid 19 100.00 Very High Very High Very High
Paracetamol 16 100.00 Very High Very High Very High
tolerance 13 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 41 100.00 Very High Very High Very High
Peptic Ulcer 1 99.96 Very High Very High Very High
INFLAMMATION 208 99.48 Very High Very High Very High
Toxicity 9 99.44 Very High Very High Very High
Colon Cancer 17 99.40 Very High Very High Very High
Brain Injury 24 99.20 Very High Very High Very High
Death 17 99.16 Very High Very High Very High
Respiratory Disease 2 99.04 Very High Very High Very High
Apoptosis 45 98.72 Very High Very High Very High
Thrombosis 12 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent in vitro studies, clinical trials and epidemiological studies have suggested possible interactions between aspirin and other cyclo-oxygenase (COX) inhibitors, such as ibuprofen of the COX-2 inhibitors celecoxib and rofecoxib.
COX Binding (interactions) of associated with aspirin and cox-2 inhibitor
1) Confidence 0.34 Published 2004 Journal Fundam Clin Pharmacol Section Abstract Doc Link 15482377 Disease Relevance 0.33 Pain Relevance 0.36
We found that HCys binds the COX cofactor Cu(2+), and Cu(2+) supplementation prior to HCys treatment preserved COX activity and prevented cell death.
COX Binding (binds) of associated with death
2) Confidence 0.30 Published 2006 Journal Neurobiol. Dis. Section Abstract Doc Link 16876425 Disease Relevance 0.95 Pain Relevance 0.09
Taken together, our data suggest that selective 6-OHDA toxicity to dopaminergic neurons is associated with neuronal COX-2, whereas MPP+ toxicity is COX independent.
COX Binding (associated) of in neuronal associated with toxicity
3) Confidence 0.30 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 15931668 Disease Relevance 0.73 Pain Relevance 0
Therefore, it seems possible that melatonin might bind to the active site of COX-1 and COX-2 suggesting that it may act as a natural inhibitor of the functions of cyclooxygenase modulating in a natural manner the activity of this enzyme.
COX Spec (might) Binding (bind) of
4) Confidence 0.27 Published 2007 Journal Arzneimittelforschung Section Abstract Doc Link 18380411 Disease Relevance 0.40 Pain Relevance 0.32
The structural interactions of melatonin with cyclooxygenase (COX), the pharmacological target of NSAIDs, were investigated using computer graphics applications.
COX Binding (interactions) of associated with cinod
5) Confidence 0.27 Published 2007 Journal Arzneimittelforschung Section Abstract Doc Link 18380411 Disease Relevance 0.52 Pain Relevance 0.41
Therefore, it seems possible that melatonin might bind to the active site of COX-1 and COX-2 suggesting that it may act as a natural inhibitor of the functions of cyclooxygenase modulating in a natural manner the activity of this enzyme.
COX Spec (might) Binding (bind) of
6) Confidence 0.27 Published 2007 Journal Arzneimittelforschung Section Abstract Doc Link 18380411 Disease Relevance 0.40 Pain Relevance 0.32
These results demonstrate an additive interaction between topical COX-2 inhibitors with intraperitoneal dexmedetomidine.
COX Binding (interaction) of associated with cox-2 inhibitor
7) Confidence 0.27 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17126828 Disease Relevance 0.11 Pain Relevance 1.03
Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model.
COX Binding (Interactions) of associated with aspirin, cinod, cox-2 inhibitor and thrombosis
8) Confidence 0.26 Published 2004 Journal Fundam Clin Pharmacol Section Title Doc Link 15482377 Disease Relevance 0.46 Pain Relevance 0.73
Cyclooxygenase (COX) inhibitors may also play a role in morphine tolerance by interacting with both systems.
COX Binding (interacting) of associated with tolerance and morphine
9) Confidence 0.22 Published 2000 Journal Br J Anaesth Section Abstract Doc Link 11094592 Disease Relevance 0 Pain Relevance 1.03
In a chronic model, by acetic acid-induced gastric ulcers, COX-2 was expressed at 7 days and was also associated with PGE(2) increase.
COX Binding (associated) of associated with peptic ulcer
10) Confidence 0.21 Published 2005 Journal Int. Immunopharmacol. Section Abstract Doc Link 15652766 Disease Relevance 0.53 Pain Relevance 0.18
Thus meloxicam inhibits spinal reflexes, whereas indomethacin does not, despite its high affinity for both COX isoforms.
COX Binding (affinity) of in spinal
11) Confidence 0.20 Published 1998 Journal Neuroreport Section Abstract Doc Link 9559932 Disease Relevance 0.23 Pain Relevance 0.32
This paper details tenidap's cyclooxygenase (COX) inhibitory activity and the resulting pharmacological properties in experimental animals.
COX Binding (activity) of
12) Confidence 0.19 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8907585 Disease Relevance 0.43 Pain Relevance 0.25
Celecoxib, a cyclooxygenase (COX) 2 inhibitor, has not been reported to interact with methotrexate, but the mechanisms are unclear why the interaction did not occur.
COX Binding (interact) of associated with methotrexate
13) Confidence 0.19 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20478302 Disease Relevance 0.09 Pain Relevance 0.49
The results indicated that melatonin has an excellent steric and electronic complementarity with COX.
COX Binding (complementarity) of
14) Confidence 0.18 Published 2007 Journal Arzneimittelforschung Section Abstract Doc Link 18380411 Disease Relevance 0.48 Pain Relevance 0.37
Active research is being conducted to unravel the cellular mechanisms mediating the anti-tumorigenic effects of nonsteroidal anti-inflammatory drugs (NSAIDs) and their association with cyclooxygenase (COX) inhibition.
COX Binding (association) of associated with inflammation and cinod
15) Confidence 0.16 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 11853685 Disease Relevance 0.41 Pain Relevance 0.63
Taken together, these data indicate that there is a significant interaction between the opioid system and COX-2 inhibitor antinociception.
COX Binding (interaction) of associated with antinociception, cox-2 inhibitor and opioid
16) Confidence 0.16 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC3000619 Disease Relevance 0.38 Pain Relevance 1.66
Some COX inhibitors, such as paracetamol [14], have been reported to be able to bind to opioid receptors.
COX Binding (bind) of associated with paracetamol and opioid receptor
17) Confidence 0.14 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC3000619 Disease Relevance 0.38 Pain Relevance 1.84
The IC50 values for both COX-1 and COX-2 were >150 ?
COX Binding (>150) of
18) Confidence 0.14 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2906419 Disease Relevance 0.40 Pain Relevance 0.03
The inhibition of COX-1 up- regulates COX-2 expression, and COX-2/PGs may, in turn, counteract the deleterious affects of gastric hypermotility due to COX-1 inhibition.


COX Binding (counteract) of
19) Confidence 0.13 Published 2002 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 11966529 Disease Relevance 0 Pain Relevance 0
For example, the IC50 for COX-2 inhibition of PG production by indomethacin when treated with endotoxin-stimulated broken macrophage was 1.1 ?
COX Binding (1.1) of in macrophage
20) Confidence 0.13 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1458335 Disease Relevance 0.29 Pain Relevance 0.21

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