INT55342

Context Info Confidence 0.37 First Reported 1994 Last Reported 2010 Negated 0 Speculated 3 Reported most in Abstract Documents 49 Total Number 52 Disease Relevance 31.62 Pain Relevance 8.93

cell differentiation (Ros1) cell proliferation (Ros1) plasma membrane (Ros1)

Anatomy Link Frequency macrophages 4 hepatocytes 4 cardiomyocytes 4 embryos 2 liver 2 Ros1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cva 71 100.00 cINOD 22 99.98 Paracetamol 182 99.54 diclofenac 4 99.52 qutenza 20 99.40 tolerance 23 99.12 medulla 19 98.98 ischemia 302 98.88 B1 receptor 91 98.72 rheumatoid arthritis 57 98.64

Disease Link Frequency Relevance Heat Hemorrhage 94 100.00 Hepatotoxicity 55 99.96 Hemorrhagic Shock 25 99.92 Apoptosis 507 99.84 Injury 310 99.76 Diabetes Mellitus 593 99.68 Impaired Glucose Tolerance 22 99.44 Stress 361 99.42 Myocardial Infarction 76 99.36 Necrosis 94 99.30

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Both Vimang and mangiferin showed inhibitory effects on macrophage activity: (a) intraperitoneal doses of only 50-250 mg/kg markedly reduced the number of macrophages in peritoneal exudate following intraperitoneal injection of thioglycollate 5 days previously (though there was no significant effect on the proportion of macrophages in the peritoneal-exudate cell population); (b) in vitro concentrations of 0.1-100 microg/ml reduced the phagocytosis of yeasts cells by resident peritoneal and thioglycollate-elicited macrophages; (c) in vitro concentrations of 1-50 microg/ml reduced nitric oxide (NO) production by thioglycollate-elicited macrophages stimulated in vitro with lipopolysaccharide (LPS) and IFNgamma; and (d) in vitro concentrations of 1-50 microg/ml reduced the extracellular production of reactive oxygen species (ROS) by resident and thioglycollate-elicited macrophages stimulated in vitro with phorbol myristate acetate (PMA).

Negative_regulation (reduced) of Gene_expression (production) of ROS in elicited macrophages

1) Confidence 0.37 Published 2002 Journal Int. Immunopharmacol. Section Abstract Doc Link 12095170 Disease Relevance 0.13 Pain Relevance 0.09

It is concluded that capsaicin or curcumin in combination with dietary fatty acids differentially lowers the production of ROS in macrophages.

Negative_regulation (lowers) of Gene_expression (production) of ROS in macrophages associated with qutenza

2) Confidence 0.37 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 7981240 Disease Relevance 0 Pain Relevance 0.38

Capsaicin and curcumin feeding further lowered the generation and release of ROS.

Negative_regulation (lowered) of Gene_expression (generation) of ROS associated with qutenza

3) Confidence 0.37 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 7981240 Disease Relevance 0 Pain Relevance 0.40

With propofol infusion, there was decreased ROS production from the reperfused liver, with less hepato-cellular injury, followed by well-maintained pulmonary function.

Negative_regulation (decreased) of Gene_expression (production) of ROS in liver

4) Confidence 0.34 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18806041 Disease Relevance 0 Pain Relevance 0

This study shows good agreement between different methods of determining ROS formation, and that inhibition of ROS formation in vivo is paralleled by a decrease in inflammation.

Negative_regulation (inhibition) of Gene_expression (formation) of ROS associated with inflammation

5) Confidence 0.34 Published 2003 Journal Inflammopharmacology Section Abstract Doc Link 15035735 Disease Relevance 0.73 Pain Relevance 0.18

Antioxidants significantly inhibited ROS generation.

Negative_regulation (inhibited) of Gene_expression (generation) of ROS

6) Confidence 0.28 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17761838 Disease Relevance 0.35 Pain Relevance 0.21

Except for naproxen, NSAIDs reduced ROS production: 58 +/- 2% diclofenac, 90 +/- 2% indomethacin, 33 +/- 3% piroxicam, and 45 +/- 6% tenoxicam (N = 6).

Negative_regulation (reduced) of Gene_expression (production) of ROS associated with cinod and diclofenac

7) Confidence 0.26 Published 2005 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 15962179 Disease Relevance 0.43 Pain Relevance 0.67

This cardioprotective activity of ALA might be associated with an anti-apoptotic effect of ALA via suppression of ROS generation, increase of pERK 1/2 and decrease of pJNK 1/2 activity.

Negative_regulation (suppression) of Gene_expression (generation) of ROS associated with apoptosis

8) Confidence 0.23 Published 2009 Journal Korean Circulation Journal Section Abstract Doc Link PMC2771824 Disease Relevance 0.40 Pain Relevance 0

However, ROS are formed in excessive amounts within the first few minutes following reperfusion and are considered a major factor involved in myocardial reperfusion injury.5)21-23) To minimize reperfusion injury, powerful antioxidants have been administered to reduce ROS generation and thereby decrease myocardial injury.17)24)25) Among the antioxidants, ALA, a thiol compound, is a cofactor for mitochondrial dehydration enzymes.

Negative_regulation (reduce) of Gene_expression (generation) of ROS associated with reperfusion injury, myocardial reperfusion injury, volume depletion and dehydration and injury

9) Confidence 0.23 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771824 Disease Relevance 1.90 Pain Relevance 0.21

These findings suggest that the cardioprotective effects of ALA might be closely associated with the suppression of apoptosis due to decreased generation of ROS.

Negative_regulation (decreased) of Gene_expression (generation) of ROS associated with apoptosis

10) Confidence 0.23 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771824 Disease Relevance 0.96 Pain Relevance 0.11

On polarized light microscopy, using a detector for active oxygen, CM-H2DCFDA, in the ALA 25 mg/kg group compared to the control group, showed that the generation of ROS was significantly suppressed at the site of myocardial infarction (p<0.0001).

Negative_regulation (suppressed) of Gene_expression (generation) of ROS associated with myocardial infarction

11) Confidence 0.23 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771824 Disease Relevance 0.83 Pain Relevance 0.15

As such, a more effective approach is to enhance mitochondrial metabolism by reducing electron leakage with attendant reduction of ROS generation.

Negative_regulation (reduction) of Gene_expression (generation) of ROS

12) Confidence 0.21 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2858081 Disease Relevance 0.37 Pain Relevance 0

Determination of ROS formation

Negative_regulation (Determination) of Gene_expression (formation) of ROS

13) Confidence 0.15 Published 2010 Journal Chin Med Section Body Doc Link PMC2978211 Disease Relevance 0 Pain Relevance 0

The highest ROS production was measured after 12 h treatment.

Negative_regulation (measured) of Gene_expression (production) of ROS

14) Confidence 0.14 Published 2009 Journal Physiol Res Section Abstract Doc Link 18380536 Disease Relevance 0.06 Pain Relevance 0.85

The increases in both [Ca(2+)](c) and ROS production were completely abolished in calcium-free buffer or by a TRPV1 antagonist capsazepine.

Negative_regulation (abolished) of Gene_expression (production) of ROS associated with antagonist

15) Confidence 0.14 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18331834 Disease Relevance 0.41 Pain Relevance 0.44

PZ prevented ROS production and the increase in protein S-oxidation.

Negative_regulation (prevented) of Gene_expression (production) of ROS

16) Confidence 0.14 Published 2010 Journal J. Gastroenterol. Section Body Doc Link 20174833 Disease Relevance 0.06 Pain Relevance 0

Taken together these results suggests that acetaminophen may attenuate the age-associated increases in the cardiomyocyte apoptosis, possibly via diminishing age associated elevation in ROS production.

Negative_regulation (diminishing) of Gene_expression (production) of ROS in cardiomyocyte associated with paracetamol and apoptosis

17) Confidence 0.13 Published 2010 Journal Basic Res. Cardiol. Section Abstract Doc Link 20407780 Disease Relevance 0.45 Pain Relevance 0.32

To summarise, it seems that AAP concentrations up to 100 µM or AAP doses up to 100 mg/Kg prevent ROS production and citotoxicity, but higher doses do not.

Negative_regulation (prevent) of Gene_expression (production) of ROS associated with paracetamol

18) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.61 Pain Relevance 1.12

Interestingly, recent experiments in arthritis-prone rats found that animals with an altered form of one of the subunits of this complex, Ncf1, that decreased the production of ROS also had greater susceptibility to arthritis.

Negative_regulation (decreased) of Gene_expression (production) of ROS associated with arthritis

19) Confidence 0.12 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1564167 Disease Relevance 1.70 Pain Relevance 0.63

For example, it is not known whether reduced capacity to produce ROS is a significant factor in human RA.

Spec (whether) Negative_regulation (reduced) of Gene_expression (produce) of ROS associated with rheumatoid arthritis

20) Confidence 0.12 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1564167 Disease Relevance 0.74 Pain Relevance 0.40

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