INT55343

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Context Info
Confidence 0.60
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 39
Total Number 39
Disease Relevance 34.51
Pain Relevance 12.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) plasma membrane (Ros1)
Anatomy Link Frequency
neutrophils 6
Macrophages 2
microglia 2
hepatocytes 1
liver 1
Ros1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 367 100.00 Very High Very High Very High
cytokine 244 100.00 Very High Very High Very High
Inflammatory mediators 40 100.00 Very High Very High Very High
Glutamate 37 100.00 Very High Very High Very High
substance P 24 100.00 Very High Very High Very High
chemokine 7 99.28 Very High Very High Very High
cva 131 99.20 Very High Very High Very High
nociceptor 4 99.20 Very High Very High Very High
excitatory amino acid 3 99.00 Very High Very High Very High
qutenza 11 98.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 458 100.00 Very High Very High Very High
Obesity 119 99.84 Very High Very High Very High
Drug Induced Neurotoxicity 22 99.72 Very High Very High Very High
Stress 338 99.70 Very High Very High Very High
Injury 237 99.56 Very High Very High Very High
Nociception 19 99.44 Very High Very High Very High
Inflammatory Bowel Disease 71 99.30 Very High Very High Very High
Hemorrhage 139 99.20 Very High Very High Very High
Shock 11 99.14 Very High Very High Very High
Neurodegenerative Disease 39 99.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin and curcumin feeding further lowered the generation and release of ROS.
Localization (release) of ROS associated with qutenza
1) Confidence 0.60 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 7981240 Disease Relevance 0 Pain Relevance 0.40
Particularly in the early stage of reperfusion, an excessive amount of ROS generation in the endothelial cells and cardiac cells stimulates inflammatory cells and the activated inflammatory cells release ROS.
Localization (release) of ROS in endothelial cells associated with inflammation
2) Confidence 0.43 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771824 Disease Relevance 1.03 Pain Relevance 0.18
The release of reactive oxygen specie (ROS) by activated neutrophil is involved in both the antimicrobial and deleterious effects in chronic inflammation.
Localization (release) of ROS in neutrophil associated with inflammation
3) Confidence 0.43 Published 2005 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 15962179 Disease Relevance 0.25 Pain Relevance 0.32
Previous studies indicated that ROS are also related to impaired baroreflex.9,10 It was found that increased cholesterol levels were associated with baroreflex gain (?
Neg (impaired) Localization (related) of ROS
4) Confidence 0.38 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020346 Disease Relevance 0.13 Pain Relevance 0.17
These results suggest that ROS is related to the increase of nociceptor sensitivity, as well as pain transmission pathway and mechanism, and may serve as the proofs that show the action of ROS in peripheral tissue on chronic pain.
Localization (related) of ROS in nociceptor associated with pain, lasting pain and nociceptor
5) Confidence 0.29 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2884210 Disease Relevance 1.10 Pain Relevance 1.06
Reactive oxygen species (ROS), secretion of cytokine, immunological and inflammatory responses, abnormal responses of the autonomic nerve system, and changes in the central nervous system have been suggested as the cause of CRPS, but the detailed mechanism has not yet been clarified [1].
Localization (secretion) of ROS in autonomic associated with inflammatory response, reflex sympathetic dystrophy, central nervous system and cytokine
6) Confidence 0.28 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2884210 Disease Relevance 1.82 Pain Relevance 1.17
Our prior studies demonstrated that peri-sciatic zymosan activated macrophages and neutrophils to release proinflammatory cytokines and reactive oxygen species (ROS).
Localization (release) of ROS in neutrophils associated with cytokine
7) Confidence 0.24 Published 2004 Journal Pain Section Abstract Doc Link 15275780 Disease Relevance 1.15 Pain Relevance 0.62
After engulfing invading bacteria, neutrophils release an “oxidative burst” of ROS—essentially the subcellular equivalent of pouring hydrogen peroxide on a wound to disinfect it.
Localization (release) of ROS in neutrophils associated with injury
8) Confidence 0.23 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1564167 Disease Relevance 1.94 Pain Relevance 0.66
To test whether impaired vasodilation in arteries from HSD and HFD is due to an interaction of ROS and NO, vessels from each group were incubated in the presence of both the NOS inhibitor LNNA and the ROS scavengers tiron and catalase or EUK-134.
Localization (tiron) of ROS in vessels associated with increased venous pressure under development
9) Confidence 0.23 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2887873 Disease Relevance 0.92 Pain Relevance 0.08
Measurement of Vascular ROS
Localization (Measurement) of ROS
10) Confidence 0.23 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2887873 Disease Relevance 0 Pain Relevance 0
These results indicate that SLD/LPS treatment causes oxidative stress in livers of rats and suggest that ROS are important in SLD/LPS-induced liver injury in vivo.
Localization (important) of ROS in liver associated with stress and injury
11) Confidence 0.22 Published 2010 Journal Toxicology Section Abstract Doc Link 20371263 Disease Relevance 0.83 Pain Relevance 0
Specificity of DCF fluorescence as a measure of ROS was verified in prior experiments in our laboratory [24,25].


Localization (measure) of ROS
12) Confidence 0.22 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2887873 Disease Relevance 0.16 Pain Relevance 0.09
Compromised vascular dilatation by diabetic lesion results from an excess of ROS (reactive oxygen species), which is evidenced that ROS are released from cardiomyocyte while incubated with high glucose.14 It has been widely accepted that ROS induced by hyperglycemia contribute to vascular endothelium dysfunction in diabetes.15 A variety of enzymatic and non-enzymatic sources of ROS exist in the blood vessels, including NADPH oxidase (NOX), mitochondrial electron transport chain, xanthine oxidase, and nitric oxide synthase.
Localization (released) of ROS in blood vessels associated with hyperglycemia and diabetes mellitus
13) Confidence 0.20 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.98 Pain Relevance 0.06
The improvement of survival (Fig. 1), decrease of hepatic injury (Fig. 2) and suppression of proinflammatory cytokine formation (Fig. 3) by polyphenols are most likely the consequence of ROS and RNS scavenging.
Localization (scavenging) of ROS associated with injury and cytokine
14) Confidence 0.18 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2936410 Disease Relevance 0.78 Pain Relevance 0.31
Consistent with these observations, our rat model of hemorrhage/resuscitation led to increased hepatic formation of both ROS and RNS, as evidenced by hepatic 4-HNE adduct formation (Fig. 4), protein nitration (Fig. 5) and increased iNOS expression (Fig 6).
Localization (formation) of ROS associated with cva
15) Confidence 0.18 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2936410 Disease Relevance 0.66 Pain Relevance 0.23
Additionally, ROS and RNS trigger release of cytokines and chemokines, leading to surface expression of adhesion molecules and leukocyte infiltration.
Localization (release) of ROS in leukocyte associated with chemokine, adhesions and cytokine
16) Confidence 0.17 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2936410 Disease Relevance 1.51 Pain Relevance 0.29
ROS, namely superoxide anion [30] and H2O2 [31] are two of the vasoactive substances released by PVAT.
Localization (released) of ROS associated with obesity
17) Confidence 0.14 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2974659 Disease Relevance 0.71 Pain Relevance 0.08
Activated neutrophils not only produce ROS but also release proteases from the cells [33, 34].
Localization (release) of ROS in neutrophils
18) Confidence 0.11 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 0.40 Pain Relevance 0.06
Our prior studies demonstrated that peri-sciatic zymosan activated macrophages and neutrophils to release proinflammatory cytokines and reactive oxygen species (ROS).
Localization (release) of ROS in macrophages associated with cytokine
19) Confidence 0.08 Published 2004 Journal Pain Section Abstract Doc Link 15275780 Disease Relevance 1.15 Pain Relevance 0.62
Therefore, the suppression of B1R expression by fluorocitrate and minocycline is most likely linked to the inhibition of pro-inflammatory cytokines and ROS released from microglia.
Localization (released) of ROS in microglia associated with inflammation, b1 receptor and cytokine
20) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.61 Pain Relevance 0.72

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