INT55344

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Context Info
Confidence 0.54
First Reported 1994
Last Reported 2011
Negated 6
Speculated 9
Reported most in Abstract
Documents 396
Total Number 405
Disease Relevance 217.64
Pain Relevance 59.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) plasma membrane (Ros1)
Anatomy Link Frequency
NR8383 10
neuronal 9
T cells 9
liver 8
neutrophils 6
Ros1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 1929 100.00 Very High Very High Very High
cytokine 544 100.00 Very High Very High Very High
Inflammatory mediators 77 100.00 Very High Very High Very High
diclofenac 292 99.92 Very High Very High Very High
Visceral pain 4 99.88 Very High Very High Very High
Paracetamol 2127 99.84 Very High Very High Very High
cerebral cortex 28 99.84 Very High Very High Very High
cINOD 173 99.82 Very High Very High Very High
Sciatic nerve 9 99.76 Very High Very High Very High
Glutamate 223 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2151 100.00 Very High Very High Very High
Apoptosis 2968 99.98 Very High Very High Very High
Injury 1513 99.92 Very High Very High Very High
Stress 3767 99.90 Very High Very High Very High
Pneumonia 18 99.90 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

4 99.88 Very High Very High Very High
Diabetes Mellitus 3086 99.84 Very High Very High Very High
Reprotox - General 1 127 99.84 Very High Very High Very High
Hyperoxia 54 99.82 Very High Very High Very High
Hyperglycemia 227 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study shows good agreement between different methods of determining ROS formation, and that inhibition of ROS formation in vivo is paralleled by a decrease in inflammation.
Gene_expression (formation) of ROS associated with inflammation
1) Confidence 0.54 Published 2003 Journal Inflammopharmacology Section Abstract Doc Link 15035735 Disease Relevance 0.73 Pain Relevance 0.18
ROS levels in the cochlea were found the be significantly higher 1 hr after exposure to 110 dB noise (Ohlemiller et al. 1999a), persisting after the cessation of the exposure (Ohlemiller et al. 1999b).
Gene_expression (levels) of ROS in cochlea
2) Confidence 0.53 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1253657 Disease Relevance 0.13 Pain Relevance 0.03
To examine a possible involvement of reactive oxygen species (ROS) in visceral pain, the levels of ROS in the colon and the effect of a ROS scavenger phenyl N-t-butylnitrone (PBN) on pain were examined in zymosan-induced colitis rats.
Spec (examined) Gene_expression (levels) of ROS in visceral associated with colitis, pain and visceral pain
3) Confidence 0.53 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18514415 Disease Relevance 0.19 Pain Relevance 0.40
The present experiments were designed to extend our observations of the initial microcirculatory response to hypoxia; specifically, we wanted to determine whether the response to systemic hypoxia involves increased microvascular permeability and leukocyte emigration and whether ROS generation and decreased NO levels contribute to these responses.
Gene_expression (generation) of ROS in leukocyte associated with hypoxia
4) Confidence 0.52 Published 2000 Journal J. Appl. Physiol. Section Abstract Doc Link 11007596 Disease Relevance 0.72 Pain Relevance 0.07
Furthermore, these events are dependent on increased ROS generation and, possibly, a subsequent decrease in tissue NO levels during systemic hypoxia.
Gene_expression (generation) of ROS associated with hypoxia
5) Confidence 0.52 Published 2000 Journal J. Appl. Physiol. Section Abstract Doc Link 11007596 Disease Relevance 0.71 Pain Relevance 0.09
Overall, these results show the potentials of noninvasive assessment of ROS production and the sites of damage by in vivo ESR using nitroxyl probes directed to specific subcellular regions.
Gene_expression (production) of ROS
6) Confidence 0.52 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16339915 Disease Relevance 0.39 Pain Relevance 0
To assess the sites of ROS generation, we applied the noninvasive measurement of ROS to indomethacin-treated rats.
Gene_expression (generation) of ROS
7) Confidence 0.52 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16339915 Disease Relevance 0.32 Pain Relevance 0.10
The enhanced signal decay caused by ROS generation in stomach, contributing to the ulcer formation induced by indomethacin, is also suggested to occur at the gastric mucus layer or the interface or the intracellular compartment of epithelial cells.
Gene_expression (generation) of ROS in epithelial cells associated with ulcers
8) Confidence 0.52 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16339915 Disease Relevance 0.49 Pain Relevance 0.05
However, the location and the time course of ROS generation remain unknown.
Gene_expression (generation) of ROS
9) Confidence 0.52 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16339915 Disease Relevance 0.32 Pain Relevance 0.10
Both Vimang and mangiferin showed inhibitory effects on macrophage activity: (a) intraperitoneal doses of only 50-250 mg/kg markedly reduced the number of macrophages in peritoneal exudate following intraperitoneal injection of thioglycollate 5 days previously (though there was no significant effect on the proportion of macrophages in the peritoneal-exudate cell population); (b) in vitro concentrations of 0.1-100 microg/ml reduced the phagocytosis of yeasts cells by resident peritoneal and thioglycollate-elicited macrophages; (c) in vitro concentrations of 1-50 microg/ml reduced nitric oxide (NO) production by thioglycollate-elicited macrophages stimulated in vitro with lipopolysaccharide (LPS) and IFNgamma; and (d) in vitro concentrations of 1-50 microg/ml reduced the extracellular production of reactive oxygen species (ROS) by resident and thioglycollate-elicited macrophages stimulated in vitro with phorbol myristate acetate (PMA).
Gene_expression (production) of ROS in elicited macrophages
10) Confidence 0.52 Published 2002 Journal Int. Immunopharmacol. Section Abstract Doc Link 12095170 Disease Relevance 0.13 Pain Relevance 0.09
It is concluded that capsaicin or curcumin in combination with dietary fatty acids differentially lowers the production of ROS in macrophages.
Gene_expression (production) of ROS in macrophages associated with qutenza
11) Confidence 0.51 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 7981240 Disease Relevance 0 Pain Relevance 0.38
The peritoneal macrophages isolated from these animals produced lower levels of ROS compared to the macrophages from the control groups fed with the oil alone.
Gene_expression (produced) of ROS in peritoneal macrophages
12) Confidence 0.51 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 7981240 Disease Relevance 0.13 Pain Relevance 0.43
Peanut oil and olive oil feeding also lowered the extent of ROS generation in macrophages compared to those from coconut oil fed animals.
Gene_expression (generation) of ROS in macrophages
13) Confidence 0.51 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 7981240 Disease Relevance 0.05 Pain Relevance 0.42
Capsaicin and curcumin feeding further lowered the generation and release of ROS.
Gene_expression (generation) of ROS associated with qutenza
14) Confidence 0.51 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 7981240 Disease Relevance 0 Pain Relevance 0.40
Our findings suggest that laryngeal insult with acid-pepsin or H(2)O(2) induces inflammation and produces excess ROS in the rat's larynx.
Gene_expression (produces) of ROS in larynx associated with inflammation
15) Confidence 0.51 Published 2009 Journal J. Appl. Physiol. Section Abstract Doc Link 19246655 Disease Relevance 0.64 Pain Relevance 0.31
Since oxidation of DA and xanthines generates reactive oxygen species (ROS) and AA and UA are the main cellular antioxidants, these findings suggest that: (a) single morphine administration increases DA and xanthine oxidative metabolism with a consequent increase in ROS production, which may account for changes in concentrations of extracellular AA and tissue DHAA; (b) allopurinol decreases morphine-induced DA and xanthine oxidation; (c) UA and AA may act in concert to regulate levels of ROS in the brain.
Gene_expression (production) of ROS in brain associated with dopamine and morphine
16) Confidence 0.49 Published 1997 Journal Pharmacol. Res. Section Abstract Doc Link 9356212 Disease Relevance 0 Pain Relevance 0.88
ROS production was significantly increased and was highest in samples from the inferior vena cava.
Gene_expression (production) of ROS in inferior vena cava
17) Confidence 0.48 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18806041 Disease Relevance 0 Pain Relevance 0
With propofol infusion, there was decreased ROS production from the reperfused liver, with less hepato-cellular injury, followed by well-maintained pulmonary function.
Gene_expression (production) of ROS in liver
18) Confidence 0.48 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18806041 Disease Relevance 0 Pain Relevance 0
Hepato-cellular injuries were confirmed by alanine aminotransferase, whereas ROS production was measured from the inferior vena cava, jugular vein, and carotid artery.
Gene_expression (production) of ROS in carotid artery
19) Confidence 0.48 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18806041 Disease Relevance 0 Pain Relevance 0
In this study, we developed a model to study pulmonary function with hepatic ischemia/reperfusion (I/R) manipulation, with the aim of defining remote pulmonary dysfunction after hepatic reperfusion and determining if propofol affects this dysfunction by altering ROS production from the liver or lungs.
Gene_expression (production) of ROS in lungs associated with ischemia
20) Confidence 0.48 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18806041 Disease Relevance 0.18 Pain Relevance 0.05

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