INT55351

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Context Info
Confidence 0.45
First Reported 1994
Last Reported 2002
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cofactor metabolic process (Ppt1) Golgi apparatus (Ppt1) cytosol (Ppt1)
extracellular space (Ppt1) protein modification process (Ppt1) extracellular region (Ppt1)
Anatomy Link Frequency
striatum 2
Ppt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 16 99.32 Very High Very High Very High
antagonist 3 82.64 Quite High
Nucleus accumbens 4 79.24 Quite High
Enkephalin 9 77.44 Quite High
Neuropeptide 2 75.00 Quite High
projection neuron 2 74.72 Quite High
Serotonin 1 66.20 Quite High
agonist 1 42.96 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decrease in PPT-A mRNA levels induced by the neonatal DA lesion was not changed after SR46349B treatment in the posterior part of the lesioned striatum.
Positive_regulation (induced) of Negative_regulation (decrease) of PPT in striatum associated with dopamine
1) Confidence 0.45 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 11754083 Disease Relevance 0 Pain Relevance 0.49
Cortical transections did not significantly affect the 6-OHDA-lesion-induced down-regulation of PPT mRNA in any of the striatal regions analysed.
Neg (not) Positive_regulation (induced) of Negative_regulation (down-regulation) of PPT mRNA
2) Confidence 0.45 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7981878 Disease Relevance 0 Pain Relevance 0.36
The present results demonstrate that knife-cut transections of the frontal corticostriatal pathway are capable of reversing the increased striatal PPE mRNA levels, but not the decreased PPT mRNA levels, induced by a 6-OHDA lesion of the dopaminergic input.
Neg (not) Positive_regulation (induced) of Neg (not) Negative_regulation (decreased) of PPT mRNA
3) Confidence 0.45 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7981878 Disease Relevance 0 Pain Relevance 0.34

General Comments

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