INT55352

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Context Info
Confidence 0.44
First Reported 1994
Last Reported 2008
Negated 3
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 0.40
Pain Relevance 3.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cofactor metabolic process (Ppt1) Golgi apparatus (Ppt1) cytosol (Ppt1)
extracellular space (Ppt1) protein modification process (Ppt1) extracellular region (Ppt1)
Anatomy Link Frequency
NAc 4
sensory neurons 2
striatum 2
prefrontal 2
parabrachial nucleus 2
Ppt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 13 100.00 Very High Very High Very High
antagonist 8 100.00 Very High Very High Very High
Dopamine 23 99.96 Very High Very High Very High
substance P 14 99.80 Very High Very High Very High
parabrachial 2 99.68 Very High Very High Very High
Nucleus accumbens 16 98.92 Very High Very High Very High
Pain 4 97.60 Very High Very High Very High
Locus ceruleus 2 96.04 Very High Very High Very High
amygdala 4 95.24 Very High Very High Very High
cocaine 7 94.64 High High
Disease Link Frequency Relevance Heat
Pain 4 97.60 Very High Very High Very High
Urological Neuroanatomy 2 79.44 Quite High
Stress 3 75.00 Quite High
Body Weight 1 65.48 Quite High
Shock 1 49.04 Quite Low
Traumatic Stress Disorders 1 39.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, we monitored the effects of the compound on preproenkephalin (PPE) and preprotachykinin (PPT) gene expression in rat striatum.
Regulation (effects) of Gene_expression (expression) of PPT in striatum
1) Confidence 0.44 Published 2002 Journal Brain Res. Section Abstract Doc Link 12384245 Disease Relevance 0.08 Pain Relevance 0.16
Finally, the absence of any effect of 5-HT(2) antagonist on the expression of PPT-A mRNA in intact animals is discussed.
Regulation (effect) of Gene_expression (expression) of PPT associated with antagonist
2) Confidence 0.44 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 11754083 Disease Relevance 0 Pain Relevance 0.43
The effects of a repeated treatment with nicotine on the expression of mRNAs encoding preproenkephalin (PPE), preprotachykinin-A (PPT-A), and preprodynorphin (PPDYN) were examined by in situ hybridization histochemistry in various subregions of the nucleus accumbens (Acb).
Spec (examined) Regulation (effects) of in nucleus accumbens Spec (examined) Gene_expression (expression) of PPT in Acb associated with nucleus accumbens and nicotine
3) Confidence 0.44 Published 1996 Journal Synapse Section Abstract Doc Link 8723714 Disease Relevance 0 Pain Relevance 0.28
PPT-A mRNA expression was not significantly affected by caffeine treatment in the CPu or NAc.
Neg (not) Regulation (affected) of Gene_expression (expression) of PPT in NAc associated with nucleus accumbens
4) Confidence 0.44 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9280160 Disease Relevance 0.07 Pain Relevance 0.40
It is established that dopamine (DA) controls the expression of preprodynorphin (PPDYN), preprotachykinin A (PPT-A) and preproenkephalin (PPE) mRNAs in striatal structures.
Regulation (controls) of Gene_expression (expression) of PPT associated with dopamine
5) Confidence 0.44 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9526067 Disease Relevance 0 Pain Relevance 0.43
Knife-cut lesions of the frontal cortical pole, transecting the prefrontal corticostriatal projection at the level of the foreceps minor, displayed little or no effect on the expression of either PPE or PPT mRNA in the dopamine-intact striatum.
Neg (little) Regulation (effect) of Gene_expression (expression) of PPT mRNA in prefrontal associated with dopamine
6) Confidence 0.44 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7981878 Disease Relevance 0 Pain Relevance 0.29
The effects of knife-cut transections of the frontal cortical pole on the expression of PPE and PPT mRNA in rat striatal neurons was studied in intact striata and in striata previously denervated by a 6-hydroxydopamine (6-OHDA) lesion of the mesencephalic dopamine pathways.
Regulation (effects) of Gene_expression (expression) of PPT mRNA in pole associated with dopamine
7) Confidence 0.44 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7981878 Disease Relevance 0 Pain Relevance 0.20
On the other hand, KW-6002 did not alter the decreased gene expression of PPT in 6-OHDA-treated rats.
Neg (not) Regulation (alter) of Gene_expression (expression) of PPT
8) Confidence 0.23 Published 2002 Journal Brain Res. Section Abstract Doc Link 12384245 Disease Relevance 0.08 Pain Relevance 0.30
Altered PPT expression in the parabrachial nucleus may be involved in the altered pain processing seen in this model.
Regulation (Altered) of Gene_expression (expression) of PPT in parabrachial nucleus associated with pain and parabrachial
9) Confidence 0.21 Published 2008 Journal Brain Res. Section Abstract Doc Link 18440496 Disease Relevance 0.17 Pain Relevance 0.59
These findings show that phosphorylation of specific protein tyrosine residue(s) following IL-1 receptor activation might play a key role in IL-1beta signalling to modulate PPT gene expression and SP secretion in sensory neurons.
Regulation (modulate) of Gene_expression (expression) of PPT gene in sensory neurons associated with substance p
10) Confidence 0.18 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622206 Disease Relevance 0 Pain Relevance 0.43

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