INT5536

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Context Info
Confidence 0.59
First Reported 1980
Last Reported 2010
Negated 12
Speculated 4
Reported most in Abstract
Documents 74
Total Number 78
Disease Relevance 16.61
Pain Relevance 15.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 4
brain 2
neurons 2
macrophages 1
skeletal muscle 1
NA (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 75 100.00 Very High Very High Very High
noradrenaline 12 100.00 Very High Very High Very High
Mexiletine 27 99.72 Very High Very High Very High
tetrodotoxin 52 99.44 Very High Very High Very High
Action potential 104 99.28 Very High Very High Very High
Paracetamol 8 99.20 Very High Very High Very High
Kinase C 25 99.06 Very High Very High Very High
bradykinin 70 98.80 Very High Very High Very High
opiate 6 98.72 Very High Very High Very High
ketamine 50 98.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertrophy 7 100.00 Very High Very High Very High
Diabetes Mellitus 70 99.84 Very High Very High Very High
Hypoxia 166 99.74 Very High Very High Very High
Heart Rate Under Development 97 99.56 Very High Very High Very High
Multiple System Atrophy 5 99.54 Very High Very High Very High
Hepatotoxicity 4 99.50 Very High Very High Very High
Malignant Hyperthermia 3 99.44 Very High Very High Very High
Contracture 11 99.28 Very High Very High Very High
Sprains And Strains 79 98.96 Very High Very High Very High
Meningitis 18 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate further the role of [Na+]i in the regulation of Na+-K+-ATPase sites, we studied the effect of reduced [Na+]i on the number of Na+ pump sites and Na+-K+ pump activity using spontaneously beating cultured chick ventricular cells.
Regulation (regulation) of Na
1) Confidence 0.59 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 3942206 Disease Relevance 0 Pain Relevance 0.05
Although early studies led to the idea that Na+ channels were not subject to modulation, we now know that Na+ channel function is affected by phosphorylation.
Regulation (affected) of Na
2) Confidence 0.26 Published 2001 Journal Nat. Rev. Neurosci. Section Abstract Doc Link 11389473 Disease Relevance 0.08 Pain Relevance 0.21
Addition of fatty acids to the recording pipette produced little further change in the magnitude or TTX sensitivity of the whole cell currents in IVCT+ cells, suggesting altered functional regulation of Na+ channels in MH muscle.
Regulation (regulation) of Na in muscle associated with tetrodotoxin and malignant hyperthermia
3) Confidence 0.24 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8760064 Disease Relevance 0.21 Pain Relevance 0.44
The differential response of the patient to Na+ channel blockers prompted us to investigate the efficacy of three different compounds, flecainide, mexiletine, and ranolazine, in correcting the biophysical dysfunction of the F1473C mutant channel.
Regulation (response) of Na associated with mexiletine
4) Confidence 0.23 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0 Pain Relevance 0.11
Here we review the available evidence for the regulation of Na+ channels by phosphorylation, its molecular mechanism, and the possible ways in which it affects neuronal function.
Regulation (regulation) of Na in neuronal
5) Confidence 0.23 Published 2001 Journal Nat. Rev. Neurosci. Section Abstract Doc Link 11389473 Disease Relevance 0.10 Pain Relevance 0.23
We investigated the effects of pressure overload hypertrophy on inward sodium (I Na) and calcium currents (I Ca) in single left ventricular myocytes to determine whether changes in these current systems could account for the observed prolongation of the action potential.
Spec (investigated) Regulation (effects) of Na in myocytes associated with action potential and hypertrophy
6) Confidence 0.23 Published 2004 Journal Mol. Cell. Biochem. Section Abstract Doc Link 15362507 Disease Relevance 0.31 Pain Relevance 0.19
Cells incubated in medium containing 60, 80, 100, or 140 mM Na+ for 24 or 48 h showed an extracellular [Na+]-dependent alteration in cellular Na+ content.
Regulation (alteration) of Na
7) Confidence 0.23 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 3942206 Disease Relevance 0 Pain Relevance 0.08
Cells incubated in medium containing 60, 80, 100, or 140 mM Na+ for 24 or 48 h showed an extracellular [Na+]-dependent alteration in cellular Na+ content.
Regulation (alteration) of Na
8) Confidence 0.23 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 3942206 Disease Relevance 0 Pain Relevance 0.08
These studies suggest that exposing cultured neuronal cells to conditions that occur in the diabetic milieu alters Na+ transport and Na(+)-channel activity.
Regulation (alters) of Na in neuronal associated with diabetes mellitus
9) Confidence 0.23 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8263545 Disease Relevance 0.30 Pain Relevance 0.08
Culturing cells in medium containing 30 mM fructose as an osmotic control had no effect on Na+ flux.
Neg (no) Regulation (effect) of Na
10) Confidence 0.23 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8263545 Disease Relevance 0.23 Pain Relevance 0.09
Isolated cardiac sarcolemmal vesicles should prove a useful model system for the study of Na+/H+ exchange regulation in myocardial tissue.
Regulation (regulation) of Na in vesicles
11) Confidence 0.23 Published 1985 Journal J. Biol. Chem. Section Abstract Doc Link 2985568 Disease Relevance 0.05 Pain Relevance 0.10
These studies suggest that exposing cultured neuronal cells to conditions that occur in the diabetic milieu alters Na+ transport and Na(+)-channel activity.
Regulation (alters) of Na in neuronal associated with diabetes mellitus
12) Confidence 0.23 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8263545 Disease Relevance 0.30 Pain Relevance 0.08
Arrhenius plots for relaxation times related to the opening and closing processes affecting the Na+ and K+ channels were linear.
Regulation (affecting) of Na
13) Confidence 0.22 Published 1980 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6254565 Disease Relevance 0 Pain Relevance 0.19
Similarly, the administration of U-50,488 H (15 mg/kg i.p.) produced an increase in the MHPG and MHPG/NA ratio without any changes in the NA content.
Neg (without) Regulation (changes) of NA associated with noradrenaline
14) Confidence 0.22 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657482 Disease Relevance 0 Pain Relevance 0.76
With a dialysis probe implanted in the rat ventral hippocampus we have monitored effects on noradrenaline (NA) and dihydroxyphenylacetic acid (DOPAC) of the infusion through the dialysis probe of drugs acting at dopaminergic and noradrenergic presynaptic autoreceptors; clonidine and idazoxan produced changes in the extracellular concentration of both NA and DOPAC, whereas LY171555 and sulpiride had no effect on NA but produced changes in the concentration of DOPAC.
Neg (no) Regulation (effect) of NA in hippocampus associated with noradrenaline, hippocampus and clonidine
15) Confidence 0.22 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1353258 Disease Relevance 0 Pain Relevance 0.47
These results indicate that the CNS is involved differently on the neural regulations of the active Na+, K+ transport systems in SOL and EDL of DOCA hypertensive rats.
Regulation (regulations) of Na in neural associated with hypertension
16) Confidence 0.19 Published 1987 Journal Brain Res. Section Abstract Doc Link 3036309 Disease Relevance 0.39 Pain Relevance 0.21
Injection of curare had no effect on Na+ and K+ contents in both SOL and EDL.
Neg (no) Regulation (effect) of Na in SOL
17) Confidence 0.19 Published 1987 Journal Brain Res. Section Abstract Doc Link 3036309 Disease Relevance 0.30 Pain Relevance 0.22
Moreover, flosequinan has the potential to interact synergistically with other positive inotropic agents such as digoxin that affect Na+/Ca2+ exchange by direct or indirect actions.
Regulation (affect) of Na
18) Confidence 0.17 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9063689 Disease Relevance 0 Pain Relevance 0.11
The increase in [Na+]i was not affected by 10 microM tetrodotoxin but was suppressed by 1 microM hexamethylene amiloride (HMA).
Neg (not) Regulation (affected) of Na associated with tetrodotoxin
19) Confidence 0.16 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7900878 Disease Relevance 0.31 Pain Relevance 0.10
Thus, we investigated the effects of the Na+ channel blockers mexiletine and lidocaine on sensory spinal dorsal horn neurons.
Spec (investigated) Regulation (effects) of Na in dorsal horn associated with mexiletine, dorsal horn neuron and lidocaine
20) Confidence 0.13 Published 2009 Journal Anesth. Analg. Section Abstract Doc Link 19535719 Disease Relevance 0.44 Pain Relevance 0.70

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