INT55364

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Context Info
Confidence 0.39
First Reported 1994
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.87
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Nr3c2) nucleus (Nr3c2) cytoplasm (Nr3c2)
Anatomy Link Frequency
hypothalamus 2
hippocampus 2
Nr3c2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 10 100.00 Very High Very High Very High
Morphine 16 99.48 Very High Very High Very High
excitatory amino acid 8 99.22 Very High Very High Very High
Raphe 3 86.48 High High
medulla 1 84.64 Quite High
antagonist 5 83.44 Quite High
nMDA receptor 1 80.96 Quite High
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 10 99.98 Very High Very High Very High
Decapitation 2 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data demonstrate that prenatal stress due to maternal saline injections up-regulates MR and GR binding in the hippocampus of adult male rats and this effect is prevented by prenatal morphine exposure.
Negative_regulation (prevented) of MR Binding (binding) of in hippocampus associated with stress, hippocampus and morphine
1) Confidence 0.39 Published 2006 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 16698219 Disease Relevance 0.46 Pain Relevance 0.78
The present findings indicate EAA afferents to the MR normally exert an excitatory influence on the MR in its desynchronization of the hippocampal EEG, whereas the removal of EAA inputs to MR produces the opposite: a reduction of MR activity and hence the elicitation of theta.
Negative_regulation (reduction) of MR Binding (activity) of associated with excitatory amino acid
2) Confidence 0.36 Published 1994 Journal Brain Res. Section Abstract Doc Link 7982102 Disease Relevance 0 Pain Relevance 0.55
Moreover, prenatal stress decreases MR binding in the hippocampus of diestrous females and GR binding in the hypothalamus of estrous females.
Negative_regulation (decreases) of MR Binding (binding) of in hypothalamus associated with stress and hippocampus
3) Confidence 0.34 Published 2006 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 16698219 Disease Relevance 0.41 Pain Relevance 0.83

General Comments

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