INT55364

Context Info Confidence 0.39 First Reported 1994 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 3 Disease Relevance 0.87 Pain Relevance 2.17

endoplasmic reticulum (Nr3c2) nucleus (Nr3c2) cytoplasm (Nr3c2)

Anatomy Link Frequency hypothalamus 2 hippocampus 2 Nr3c2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Hippocampus 10 100.00 Morphine 16 99.48 excitatory amino acid 8 99.22 Raphe 3 86.48 medulla 1 84.64 antagonist 5 83.44 nMDA receptor 1 80.96 anesthesia 1 25.00

Disease Link Frequency Relevance Heat Stress 10 99.98 Decapitation 2 93.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The data demonstrate that prenatal stress due to maternal saline injections up-regulates MR and GR binding in the hippocampus of adult male rats and this effect is prevented by prenatal morphine exposure.

Negative_regulation (prevented) of MR Binding (binding) of in hippocampus associated with stress, hippocampus and morphine

1) Confidence 0.39 Published 2006 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 16698219 Disease Relevance 0.46 Pain Relevance 0.78

The present findings indicate EAA afferents to the MR normally exert an excitatory influence on the MR in its desynchronization of the hippocampal EEG, whereas the removal of EAA inputs to MR produces the opposite: a reduction of MR activity and hence the elicitation of theta.

Negative_regulation (reduction) of MR Binding (activity) of associated with excitatory amino acid

2) Confidence 0.36 Published 1994 Journal Brain Res. Section Abstract Doc Link 7982102 Disease Relevance 0 Pain Relevance 0.55

Moreover, prenatal stress decreases MR binding in the hippocampus of diestrous females and GR binding in the hypothalamus of estrous females.

Negative_regulation (decreases) of MR Binding (binding) of in hypothalamus associated with stress and hippocampus

3) Confidence 0.34 Published 2006 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 16698219 Disease Relevance 0.41 Pain Relevance 0.83

General Comments

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