INT55370

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Context Info
Confidence 0.47
First Reported 1994
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.13
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn3) extracellular region (Edn3) cellular_component (Edn3)
Anatomy Link Frequency
endothelial cells 2
sympathetic 2
Edn3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 8 99.72 Very High Very High Very High
cva 1 95.12 Very High Very High Very High
intrathecal 1 79.52 Quite High
Spinal cord 1 79.00 Quite High
Migraine 5 75.00 Quite High
Calcitonin gene-related peptide 1 67.76 Quite High
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Neurogenic Inflammation 8 99.72 Very High Very High Very High
Increased Venous Pressure Under Development 6 98.68 Very High Very High Very High
Pressure Volume 2 Under Development 3 97.88 Very High Very High Very High
Hemorrhage 1 95.12 Very High Very High Very High
Headache 5 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that sympathetic activation enhances endothelin-3 release but that nitroprusside may act directly to suppress release.
Positive_regulation (enhances) of Localization (release) of endothelin-3 in sympathetic
1) Confidence 0.47 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7982458 Disease Relevance 0.37 Pain Relevance 0.13
The release of tachykinins and endothelin-3 (ET-3) from trigeminal neurons induces dural vascular permeability and vasodilatation via activation of tachykinin receptor 1 (Tacr1) and endothelin receptor type B (Ednrb) on endothelial cells.
Positive_regulation (induces) of Localization (release) of endothelin-3 in endothelial cells associated with increased venous pressure under development
2) Confidence 0.02 Published 2005 Journal Mol. Interv. Section Abstract Doc Link 16249526 Disease Relevance 0.76 Pain Relevance 0.31

General Comments

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