INT5540

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2010
Negated 18
Speculated 18
Reported most in Abstract
Documents 344
Total Number 363
Disease Relevance 76.77
Pain Relevance 319.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
neurons 15
spinal cord 12
medulla 8
spinal 7
DRG 7
Oprm1 (Mus musculus)
Oprm1 - Y166F (1) Oprm1 - Y106F (1)
Pain Link Frequency Relevance Heat
opioid receptor 3764 100.00 Very High Very High Very High
Morphine 2588 100.00 Very High Very High Very High
Opioid 1955 100.00 Very High Very High Very High
mu opioid receptor 1697 100.00 Very High Very High Very High
narcan 723 100.00 Very High Very High Very High
agonist 682 100.00 Very High Very High Very High
analgesia 644 100.00 Very High Very High Very High
antinociception 490 100.00 Very High Very High Very High
Enkephalin 342 100.00 Very High Very High Very High
Kinase C 283 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 338 100.00 Very High Very High Very High
Stress 260 100.00 Very High Very High Very High
Endometriosis (extended) 24 100.00 Very High Very High Very High
Insulin Resistance 5 100.00 Very High Very High Very High
Nervous System Injury 31 99.98 Very High Very High Very High
Targeted Disruption 230 99.96 Very High Very High Very High
Pain 447 99.92 Very High Very High Very High
Opiate Addiction 93 99.92 Very High Very High Very High
Hyperalgesia 123 99.90 Very High Very High Very High
Neuroblastoma 35 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is hypothesized that this superior efficacy profile of tapentadol is due to simultaneous activation of MOR and inhibition of NA reuptake.
Positive_regulation (activation) of MOR in superior associated with noradrenaline and opioid receptor
1) Confidence 0.70 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20026182 Disease Relevance 1.51 Pain Relevance 1.20
Antagonistic effect of buprenorphine on the antitussive effect of morphine is mediated via the activation of mu 1-opioid receptors.
Positive_regulation (activation) of mu 1-opioid associated with qutenza, opioid receptor, morphine and buprenorphine
2) Confidence 0.70 Published 1995 Journal Life Sci. Section Title Doc Link 7564887 Disease Relevance 0.09 Pain Relevance 1.44
These results suggest that buprenorphine antagonizes the antitussive effect of morphine via the activation of mu 1-opioid receptors.
Positive_regulation (activation) of mu 1-opioid associated with opioid receptor, morphine and buprenorphine
3) Confidence 0.70 Published 1995 Journal Life Sci. Section Abstract Doc Link 7564887 Disease Relevance 0.09 Pain Relevance 1.22
After cessation of treatment, there is an increase in mu-opioid receptor mRNA level associated with the recovery of mu-opioid receptors.
Positive_regulation (increase) of mu-opioid receptor mRNA associated with mu opioid receptor and opioid receptor
4) Confidence 0.69 Published 2000 Journal Synapse Section Abstract Doc Link 10881033 Disease Relevance 0.08 Pain Relevance 0.84
Abdominal surgery induces mu opioid receptor endocytosis in enteric neurons of the guinea-pig ileum.
Positive_regulation (induces) of mu opioid receptor in neurons associated with mu opioid receptor
5) Confidence 0.69 Published 2004 Journal Neuroscience Section Title Doc Link 14667445 Disease Relevance 0 Pain Relevance 0.31
The analgesic effect of morphine was enhanced by administering the drug when mu-opioid receptor levels were increased.
Positive_regulation (increased) of mu-opioid receptor associated with analgesic, opioid receptor and morphine
6) Confidence 0.69 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16109741 Disease Relevance 0.08 Pain Relevance 1.04
Moreover, corticostriatal EPSCs were inhibited by MOR activation to similar extents in the two compartments, although inhibition of IPSCs was observed only in the striosomes.
Positive_regulation (activation) of MOR associated with opioid receptor
7) Confidence 0.69 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17804632 Disease Relevance 0.08 Pain Relevance 0.50
These findings suggest that MOR activation by endogenous and/or exogenous MOR-selective opioid substances differentially regulates the activities of the striosome and matrix compartments and thus plays an important role in motivated behavior and learning.
Positive_regulation (activation) of MOR associated with opioid receptor and opioid
8) Confidence 0.69 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17804632 Disease Relevance 0.06 Pain Relevance 0.62
These data suggest that the increase in mu-opioid receptor mRNA following the termination of etorphine treatment may drive the recovery of mu-opioid receptors.
Positive_regulation (increase) of mu-opioid receptor mRNA associated with mu opioid receptor, opioid receptor and immobilon
9) Confidence 0.69 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9450614 Disease Relevance 0 Pain Relevance 1.07
The increase in mu-opioid receptor mRNA was approximately 55-65% over control at the highest etorphine infusion dose.
Positive_regulation (increase) of mu-opioid receptor mRNA associated with opioid receptor and immobilon
10) Confidence 0.69 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9450614 Disease Relevance 0 Pain Relevance 1.28
Truncation of the mu receptor by removal of its carboxyl terminus at Glu341 did not affect the ability of the fentanyl analogs to bind to and activate the mu receptor nor did it prevent the fentanyl analogs from desensitizing the receptor.
Neg (nor) Positive_regulation (activate) of mu receptor
11) Confidence 0.69 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618424 Disease Relevance 0.06 Pain Relevance 0.65
Naloxone dose-dependently increased mu opioid receptor density.
Positive_regulation (increased) of mu opioid receptor associated with mu opioid receptor and narcan
12) Confidence 0.69 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8386239 Disease Relevance 0 Pain Relevance 1.14
CP3 protein repressed about 40% of the Oprm1 proximal promoter activity induced in pcDNA4 vector only-transfected cells (Fig. 5).


Positive_regulation (induced) of Oprm1 in proximal
13) Confidence 0.69 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2494908 Disease Relevance 0 Pain Relevance 0
By exposing the mu-receptor (MOP-R) to more than one exogenous ligand, the administration during general anaesthesia of more than one opioid with principal action on the receptor may confound and lead to complications or unexpected outcomes.
Positive_regulation (exposing) of MOP-R associated with opioid
14) Confidence 0.68 Published 2006 Journal Anaesth Intensive Care Section Abstract Doc Link 16802493 Disease Relevance 0.16 Pain Relevance 0.28
Although mu-opioid receptor density was decreased to less than 30% of control 24 h following clocinnamox (12.8 mg/kg) and had increased to 80% by 5 days, a solution hybridization assay for mu-opioid receptor mRNA transcript revealed no changes in the steady-state levels of this mRNA.
Positive_regulation (increased) of mu-opioid receptor associated with opioid receptor
15) Confidence 0.68 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8749027 Disease Relevance 0 Pain Relevance 1.55
To determine whether deltaOR trafficking induced by chronic inflammation was dependent on the activation of muOR, we investigated by immunogold cytochemistry the effects of intraplantar CFA injection on the plasma membrane density of deltaOR in muOR knockout (KO) mice.
Positive_regulation (activation) of muOR in plasma associated with targeted disruption and inflammation
16) Confidence 0.68 Published 2004 Journal Pain Section Abstract Doc Link 15157687 Disease Relevance 0.60 Pain Relevance 0.61
These results demonstrate that the integrity of muOR is necessary for CFA-induced changes in deltaOR trafficking to occur and suggest that these changes could be elicited by stimulation of muOR by endogenous opioids released in response to chronic inflammatory pain.
Positive_regulation (stimulation) of muOR associated with ipn and endogenous opioid
17) Confidence 0.68 Published 2004 Journal Pain Section Abstract Doc Link 15157687 Disease Relevance 0.58 Pain Relevance 0.56
The opioids stimulate the hypothalamus-pituitary-adrenal axis and sympathetic and adrenomedullary system, through the activation of mu-opioid receptor (MOR) to release stress hormones, such as cortisol and catecholamines, respectively.
Positive_regulation (activation) of MOR in sympathetic associated with stress, catecholamine and opioid receptor
18) Confidence 0.68 Published 2007 Journal Allergol Int Section Abstract Doc Link 17259807 Disease Relevance 1.01 Pain Relevance 0.33
The opioids stimulate the hypothalamus-pituitary-adrenal axis and sympathetic and adrenomedullary system, through the activation of mu-opioid receptor (MOR) to release stress hormones, such as cortisol and catecholamines, respectively.
Positive_regulation (activation) of mu-opioid receptor in sympathetic associated with stress, catecholamine and opioid receptor
19) Confidence 0.68 Published 2007 Journal Allergol Int Section Abstract Doc Link 17259807 Disease Relevance 1.01 Pain Relevance 0.33
In addition, repeated treatment with fentanyl, but not morphine, resulted in the increase in levels of phosphorylated-mciro-opioid receptor (MOR) associated with the enhanced inactivation of protein phosphatase 2A and the reduction in Rab4-dependent MOR resensitization.
Positive_regulation (increase) of MOR associated with opioid receptor and morphine
20) Confidence 0.67 Published 2006 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 17240843 Disease Relevance 0.59 Pain Relevance 1.33

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