INT55409

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Context Info
Confidence 0.80
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 8.99
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (VWF) cell adhesion (VWF) endoplasmic reticulum (VWF)
proteinaceous extracellular matrix (VWF)
Anatomy Link Frequency
endothelial cells 6
platelet 3
endothelium 1
VWF (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 16 99.82 Very High Very High Very High
Sumatriptan 8 99.64 Very High Very High Very High
agonist 25 99.40 Very High Very High Very High
Bioavailability 3 97.76 Very High Very High Very High
antagonist 14 95.20 Very High Very High Very High
Inflammation 71 92.52 High High
cytokine 16 91.68 High High
Pain 8 86.88 High High
Restless leg syndrome 1 84.80 Quite High
tolerance 20 67.28 Quite High
Disease Link Frequency Relevance Heat
Adhesions 33 99.60 Very High Very High Very High
Insulin Resistance 38 99.58 Very High Very High Very High
Increased Venous Pressure Under Development 62 98.40 Very High Very High Very High
Acute Coronary Syndrome 88 97.80 Very High Very High Very High
Malaria 102 97.76 Very High Very High Very High
Infection 55 97.56 Very High Very High Very High
Hypertension 25 94.16 High High
Diabetes Mellitus 205 93.64 High High
INFLAMMATION 80 92.52 High High
Collagen Disease 1 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these results suggest that in HUVEC 5-HT-induced secretion of vWf is mediated by a decrease in cyclic AMP levels and is independent of changes in cytoplasmic calcium levels.
Localization (secretion) of vWf
1) Confidence 0.80 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 11230807 Disease Relevance 0 Pain Relevance 0.28
Serotonin (5-hydroxytryptamine, 5-HT), a local transmitter substance released by activated platelets, has also recently been shown to induce the secretion of vWf.
Localization (secretion) of vWf in platelets associated with serotonin
2) Confidence 0.80 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 11230807 Disease Relevance 0 Pain Relevance 0.28
Serotonin-induced secretion of von Willebrand factor from human umbilical vein endothelial cells via the cyclic AMP-signaling systems independent of increased cytoplasmic calcium concentration.
Localization (secretion) of von Willebrand factor in endothelial cells associated with serotonin
3) Confidence 0.80 Published 1999 Journal Biochem. Pharmacol. Section Title Doc Link 11230807 Disease Relevance 0 Pain Relevance 0.25
Endothelial cells are able to synthesize von Willebrand factor (vWf) protein, which is then either secreted in a constitutive way or stored within specific cellular secretory granules, the Weibel-Palade bodies.
Localization (secreted) of vWf in Endothelial cells
4) Confidence 0.80 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 11230807 Disease Relevance 0 Pain Relevance 0.12
Stimulated secretion of vWf from these organelles is thought to be induced by agonists causing a transient increase in cytoplasmic calcium concentrations.
Localization (secretion) of vWf associated with agonist
5) Confidence 0.80 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 11230807 Disease Relevance 0 Pain Relevance 0.22
The antigen levels of von Willebrand factor (vWF), tissue plasminogen activator (t-PA), and its inhibitor (PAI) were also determined as markers of release from the endothelium, while the fragment 1 + 2 of prothrombin (F1 + 2) and thrombin-antithrombin III (TAT) complexes were assessed as indexes of systemic thrombin generation.
Localization (release) of von Willebrand factor in endothelium
6) Confidence 0.73 Published 1994 Journal Angiology Section Abstract Doc Link 7985828 Disease Relevance 1.34 Pain Relevance 0.20
The 5-HT 1(D) subtype-specific receptor agonist sumatriptan also induced the release of vWf without causing a calcium signal in HUVEC.
Localization (release) of vWf associated with sumatriptan and agonist
7) Confidence 0.71 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 11230807 Disease Relevance 0 Pain Relevance 0.31
Endothelial cells are able to synthesize von Willebrand factor (vWf) protein, which is then either secreted in a constitutive way or stored within specific cellular secretory granules, the Weibel-Palade bodies.
Localization (secreted) of von Willebrand factor in Endothelial cells
8) Confidence 0.71 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 11230807 Disease Relevance 0 Pain Relevance 0.12
Stimulation of endothelial cells with the adenylate cyclase inhibitor, MDL-12 A330, led to the secretion of vWf as well.
Localization (secretion) of vWf in endothelial cells
9) Confidence 0.71 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 11230807 Disease Relevance 0 Pain Relevance 0.30
Release of von Willebrand factor (vWF) may mediate this platelet adhesion [35].
Localization (Release) of vWF in platelet associated with adhesions
10) Confidence 0.49 Published 2009 Journal Malar J Section Body Doc Link PMC2794284 Disease Relevance 1.93 Pain Relevance 0.15
Release of von Willebrand factor (vWF) may mediate this platelet adhesion [35].
Localization (Release) of von Willebrand factor in platelet associated with adhesions
11) Confidence 0.49 Published 2009 Journal Malar J Section Body Doc Link PMC2794284 Disease Relevance 1.88 Pain Relevance 0.15
Indeed, the occurrence of endothelial cell activation with release of active vWF has previously been demonstrated in early experimental malaria infections [36].
Localization (release) of vWF in endothelial cell associated with malaria and infection
12) Confidence 0.49 Published 2009 Journal Malar J Section Body Doc Link PMC2794284 Disease Relevance 1.88 Pain Relevance 0.11
Measurement of vWF in resuscitated patients
Localization (Measurement) of vWF
13) Confidence 0.45 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 0 Pain Relevance 0
After blocking cells were labelled for 45 minutes at 37°C in the presence of a mouse monoclonal antibody (dilution of 1:50) directed against vWF (DakoCytomation, Denmark), a goat polyclonal antibody (diluition of 1:50) direct against FLT-1 (Santa Cruz Biotechnology-USA), a mouse monoclonal antibody (diluition of 1:50) directed against KDR (SigmaAldrich, Italy).
Localization (directed) of vWF
14) Confidence 0.36 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1810523 Disease Relevance 0 Pain Relevance 0
The above reflect a prothrombotic state associated with an insulin resistance state, an increased vWF release, raised sP-Sel and TNFalpha levels and, may be, low NO bioavailability, which could lead to a higher risk of development of thrombotic events in hypertensive diabetic patients (Ouvina et al 2001).
Localization (release) of vWF associated with diabetes mellitus, hypertension, insulin resistance and bioavailability
15) Confidence 0.33 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 0.97 Pain Relevance 0.21
IL-1 has been shown to augment thrombin-induced release of vWF from human endothelial cells [35].


Localization (release) of vWF in endothelial cells
16) Confidence 0.26 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 0.36 Pain Relevance 0.34
Shotgun mass spectrometry confirmed the results of 1-D gel by identifying multiple fragments of the complement cascade and in addition found EMILIN2 and Von Willebrand factor.
Localization (found) of Von Willebrand factor
17) Confidence 0.04 Published 2008 Journal J Transl Med Section Body Doc Link PMC2503970 Disease Relevance 0.65 Pain Relevance 0

General Comments

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