INT55422

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Context Info
Confidence 0.48
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.35
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Glp1r) signal transducer activity (Glp1r)
Anatomy Link Frequency
neurons 2
cardiomyocytes 1
colon 1
Glp1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 29 99.96 Very High Very High Very High
antagonist 10 99.92 Very High Very High Very High
Calcitonin gene-related peptide 2 94.00 High High
Central nervous system 68 91.32 High High
tolerance 36 90.96 High High
tetrodotoxin 2 90.76 High High
ischemia 18 85.96 High High
Neurotransmitter 6 75.00 Quite High
Cholecystokinin 1 52.72 Quite High
Somatostatin 2 52.64 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 106 99.98 Very High Very High Very High
Pancreatitis 81 98.56 Very High Very High Very High
Targeted Disruption 16 98.16 Very High Very High Very High
Myocardial Infarction 208 93.20 High High
Impaired Glucose Tolerance 37 90.96 High High
Reperfusion Injury 6 86.72 High High
Cv Unclassified Under Development 18 85.96 High High
Suicidal Behaviour 6 79.20 Quite High
Pressure And Volume Under Development 8 72.16 Quite High
Rheumatoid Arthritis 4 69.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the present study conducted with the isolated vascularly perfused rat colon shows that there are interactions between the two most potent incretins, GIP and GLP-1, probably through an enteroendocrine pathway.
GLP-1 Binding (interactions) of in colon
1) Confidence 0.48 Published 1994 Journal Endocrinology Section Abstract Doc Link 7988423 Disease Relevance 0 Pain Relevance 0.31
For generating antisense cRNAs, GLP-1 receptors and NPY plamids were linearized with HindIII, and T7 polymerase was used for in vitro transcription.
GLP-1 Binding (receptors) of
2) Confidence 0.32 Published 2008 Journal Diabetes Section Body Doc Link PMC2494674 Disease Relevance 0.21 Pain Relevance 0
Counter to expectations, the cardioprotective actions of GLP-1(9-36) were blocked by an antagonist of GLP-1R binding, yet preserved in cardiomyocytes from GLP-1R knockout mice.
GLP-1R Binding (binding) of in cardiomyocytes associated with targeted disruption and antagonist
3) Confidence 0.31 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2996354 Disease Relevance 0.82 Pain Relevance 0.15
Overall, these data lend further support to a cardio-sparing signal transduction pathway distinct from that associated with the GLP-1 receptor.


GLP-1 receptor Binding (associated) of
4) Confidence 0.31 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2996354 Disease Relevance 0.91 Pain Relevance 0.11
Further, with an insulin infusion that produces postprandial levels, we found that ARC GLP-1, compared with saline, inhibited glucose production by ?
GLP-1 Binding (compared) of associated with aids-related complex
5) Confidence 0.28 Published 2008 Journal Diabetes Section Body Doc Link PMC2494674 Disease Relevance 0.65 Pain Relevance 0.28
In the context of the heightened interest regarding the association of GLP-1 receptor agonists and DPP-4 inhibitors with pancreatitis, a search of the AERS and SRS databases for reports of pancreatitis observed with other classes of AHAs was conducted by the authors, using data from 1968 through the third quarter of 2008.
GLP-1 receptor Binding (association) of associated with pancreatitis and agonist
6) Confidence 0.08 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2904489 Disease Relevance 0.37 Pain Relevance 0.05
Recently, we reported that neurons that contain glucagon-like peptide 1 (GLP-1) and corticotropin-releasing hormone may mediate leptin signaling to histaminergic neurons within the TMN (Gotoh et al. 2005).
GLP-1 Binding (contain) of in neurons
7) Confidence 0.07 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0.20 Pain Relevance 0
Recently, we reported that neurons that contain glucagon-like peptide 1 (GLP-1) and corticotropin-releasing hormone may mediate leptin signaling to histaminergic neurons within the TMN (Gotoh et al. 2005).
glucagon-like peptide 1 Binding (contain) of in neurons
8) Confidence 0.07 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0.20 Pain Relevance 0

General Comments

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