INT55434

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Context Info
Confidence 0.38
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 10.91
Pain Relevance 4.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90B2P) protein folding (HSP90B2P) response to stress (HSP90B2P)
Anatomy Link Frequency
lens 6
macrophages 2
SK-MEL-3 2
lymphocytes 2
cornea 2
HSP90B2P (Homo sapiens)
Pain Link Frequency Relevance Heat
Antinociceptive 10 100.00 Very High Very High Very High
dexamethasone 2 99.78 Very High Very High Very High
cytokine 33 99.40 Very High Very High Very High
Inflammation 41 98.88 Very High Very High Very High
cINOD 4 98.54 Very High Very High Very High
rheumatoid arthritis 32 98.30 Very High Very High Very High
Analgesic 7 97.72 Very High Very High Very High
opiate 8 96.96 Very High Very High Very High
Spinal cord 9 96.44 Very High Very High Very High
antagonist 3 89.68 High High
Disease Link Frequency Relevance Heat
Sepsis 15 99.70 Very High Very High Very High
Skin Cancer 48 99.46 Very High Very High Very High
INFLAMMATION 46 98.88 Very High Very High Very High
Cataract 120 98.36 Very High Very High Very High
Rheumatoid Arthritis 32 98.30 Very High Very High Very High
Autoimmune Disease 1 97.92 Very High Very High Very High
Stress 194 97.00 Very High Very High Very High
Shock 136 95.60 Very High Very High Very High
Wound Healing 72 93.56 High High
Cancer 124 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, during HSP, antinociceptive responsiveness to i.t.
Positive_regulation (responsiveness) of Gene_expression (during) of HSP associated with antinociceptive
1) Confidence 0.38 Published 1996 Journal Pain Section Abstract Doc Link 8783328 Disease Relevance 0 Pain Relevance 1.60
Furthermore, during HSP, antinociceptive responsiveness to i.t.
Positive_regulation (responsiveness) of Gene_expression (during) of HSP associated with antinociceptive
2) Confidence 0.32 Published 1996 Journal Pain Section Abstract Doc Link 8867260 Disease Relevance 0.06 Pain Relevance 1.60
Since many pharmaceutical companies are developing cytokine synthesis inhibitors as potential anti-inflammatory drugs, one aim of this article is to emphasize that understanding the molecular mechanism(s) that lead to increased HSP expression and decreased cytokine biosynthesis may assist in achieving this goal.
Positive_regulation (increased) of Gene_expression (expression) of HSP associated with inflammation, cinod and cytokine
3) Confidence 0.19 Published 1994 Journal Experientia Section Abstract Doc Link 7988664 Disease Relevance 0.56 Pain Relevance 0.45
Other studies suggest that various anti-inflammatory drugs, including acetylsalicyclic acid, auranofin and dexamethasone, can also facilitate HSP expression in macrophages.
Positive_regulation (facilitate) of Gene_expression (expression) of HSP in macrophages associated with inflammation, cinod and dexamethasone
4) Confidence 0.19 Published 1994 Journal Experientia Section Abstract Doc Link 7988664 Disease Relevance 0.65 Pain Relevance 0.46
As for pathological findings; at 12 hr after preconditioning-the time of increased Hsp expression after heating and cooling, inflammation of tissues could be seen, suggesting that this weak inflammation would prepare the tissues for further inflammation and increase their resistance.
Positive_regulation (increased) of Gene_expression (expression) of Hsp associated with inflammation
5) Confidence 0.08 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.76 Pain Relevance 0.14
We confirmed the increased expression of Hsp in the cornea and lens after heating and cooling (Fig. 4).
Positive_regulation (increased) of Gene_expression (expression) of Hsp in lens
6) Confidence 0.08 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.44 Pain Relevance 0
If patients recovered from severe sepsis, there was an increase in the percentage of their lymphocytes that produced HSP-70 to endotoxin challenge.
Positive_regulation (increase) of Gene_expression (produced) of HSP in lymphocytes associated with sepsis
7) Confidence 0.07 Published 2003 Journal Crit Care Section Body Doc Link PMC270667 Disease Relevance 0.99 Pain Relevance 0.08
In comparison with the large number of investigations on autoimmunity against HSPs in RA [20], studies on the expression of HSPs in the synovial membrane and on the factors leading to synovial HSP expression have been rare.
Positive_regulation (leading) of Gene_expression (expression) of HSP associated with autoimmune disease and rheumatoid arthritis
8) Confidence 0.07 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128883 Disease Relevance 1.27 Pain Relevance 0.34
In light of these facts, the increased levels of Hsp 70 and Hsp 47 appeared to be major factors in the protection of the cornea and lens against lethal thermal damage, as well as played an important role in rapid wound healing, and decreased corneal and lens opacity after excimer laser ablation.
Positive_regulation (increased) of Gene_expression (levels) of Hsp in lens associated with wound healing and cataract
9) Confidence 0.06 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 1.28 Pain Relevance 0.04
We hypothesized that sublethal cellular heating or cooling induces Hsp expression, and that the induced Hsps may protect tissues from damage by excimer laser photoablation.
Positive_regulation (induces) of Gene_expression (expression) of Hsp
10) Confidence 0.06 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.74 Pain Relevance 0.05
In the literature, increased expression of HSP (HSP27, HSP70) plays an important role in reduced sensitivity towards cytostatic drugs [25–27].
Positive_regulation (increased) of Gene_expression (expression) of HSP
11) Confidence 0.05 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.59 Pain Relevance 0
In vitro studies in melanoma cells showed the level of HSP expression to be dependent on time and temperature, with the maximal rate of synthesis at 42°C and 9 hours exposure reaching a steady state with levels not much higher than constitutive expression following continued exposure [31].
Positive_regulation (dependent) of Gene_expression (expression) of HSP associated with skin cancer
12) Confidence 0.04 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.95 Pain Relevance 0.03
In melanoma cells not only a chemically and heat-induced expression of HSP (HSP72) has been demonstrated [31–34], but also a constitutive overexpression that was independent of stress (HSP27, HSP72, HSP90), as was the case in the SK-MEL-3 tumor.
Positive_regulation (induced) of Gene_expression (expression) of HSP in SK-MEL-3 associated with stress, cancer and skin cancer
13) Confidence 0.04 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.91 Pain Relevance 0
We confirmed the increased expression of Hsp in the cornea and lens after heating and cooling (Fig. 4).
Positive_regulation (increased) of in cornea Gene_expression (expression) of Hsp in lens
14) Confidence 0.03 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.44 Pain Relevance 0
On the other hand, no changes were observed in the cytoplasmic chaperones HSP72 or HSP 90 in either of the groups (Figure 3).
Positive_regulation (chaperones) of Neg (no) Gene_expression (observed) of HSP
15) Confidence 0.03 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0 Pain Relevance 0
In light of these facts, the increased levels of Hsp 70 and Hsp 47 appeared to be major factors in the protection of the cornea and lens against lethal thermal damage, as well as played an important role in rapid wound healing, and decreased corneal and lens opacity after excimer laser ablation.
Positive_regulation (increased) of in cornea Gene_expression (levels) of Hsp in lens associated with wound healing and cataract
16) Confidence 0.02 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 1.28 Pain Relevance 0.04

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