INT55469

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Context Info
Confidence 0.47
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 3.00
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (PTAFR) plasma membrane (PTAFR) nucleus (PTAFR)
signal transducer activity (PTAFR)
Anatomy Link Frequency
chest 2
platelet 2
esophageal epithelium 2
PTAFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 140 98.76 Very High Very High Very High
antagonist 18 98.52 Very High Very High Very High
qutenza 21 98.18 Very High Very High Very High
tetrodotoxin 3 96.72 Very High Very High Very High
addiction 7 93.36 High High
Angina 5 88.56 High High
cytokine 30 85.28 High High
substance P 27 75.04 Quite High
calcitonin gene related peptide 16 64.80 Quite High
Neurotransmitter 1 57.68 Quite High
Disease Link Frequency Relevance Heat
Injury 75 99.12 Very High Very High Very High
INFLAMMATION 148 98.76 Very High Very High Very High
Endotoxemia 7 98.64 Very High Very High Very High
Hypoxia 14 98.12 Very High Very High Very High
Mycobacterial Infection 2 95.24 Very High Very High Very High
Asthma 8 93.96 High High
Myocardial Infarction 2 90.44 High High
Cv General 3 Under Development 3 88.56 High High
Angina 2 86.84 High High
Neonatal Necrotizing Enterocolitis 238 83.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Future experiments will elucidate the exact mechanisms of STAT3 involvement, and possibly other factors, in PAF mediated transcriptional activation of TLR4 and will investigate experimental models where PAF is neutralized.
Positive_regulation (mediated) of Positive_regulation (activation) of PAF
1) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.47 Pain Relevance 0.16
These data suggest that although TLR4 is weakly expressed on the surface of IEC, platelet activating factor stimulation upregulates expression of the receptor.
Positive_regulation (upregulates) of Positive_regulation (stimulation) of platelet activating factor in platelet
2) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.14 Pain Relevance 0.09
To determine whether or not the increased mRNA of IEC following PAF stimulation leads to a corresponding increase in TLR4 protein expression, immunohistochemistry was performed.
Spec (whether) Positive_regulation (increased) of Spec (whether) Positive_regulation (following) of PAF
3) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.08 Pain Relevance 0
These results indicate that stimulation with PAF activates STAT3, a transcription factor that may be involved in TLR4 transcriptional regulation.


Positive_regulation (activates) of Positive_regulation (stimulation) of PAF
4) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0 Pain Relevance 0
We first wished to verify that PAF stimulation activated STAT3 in IEC, as was shown before in COS-7 cells.
Positive_regulation (activated) of Positive_regulation (stimulation) of PAF
5) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0 Pain Relevance 0
Our data suggest that capsaicin exerts its anti-inflammatory effect by inhibiting SOCE elicited via PLC activation, which occurs upon PAF activation and results in the subsequent superoxide production.
Positive_regulation (occurs) of Positive_regulation (activation) of PAF associated with inflammation and qutenza
6) Confidence 0.44 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11034409 Disease Relevance 0.10 Pain Relevance 0.94
Activation of its G protein-coupled receptor, PAF-receptor (PAFR), leads to activation of several signal transduction pathways including the signal transducers and activators of transcription (STATs) and NF?
Positive_regulation (leads) of Positive_regulation (Activation) of PAF
7) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 1.21 Pain Relevance 0.06
In order to determine whether stimulation with PAF can affect TLR4 promoter activation, we first transiently transfected HEK293 cells (which express negligible endogenous PAFR and TLR4) with a TLR4 promoter-luciferase reporter construct and PAFR cDNA.
Positive_regulation (negligible) of Positive_regulation (endogenous) of PAFR
8) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.08 Pain Relevance 0.09
The HCl-induced increase in PAF was abolished by the TRPV1 receptor antagonist IRTX but not by neural block with tetrodotoxin, indicating that production of PAF may arise from non-neural pathways, and most likely from the esophageal epithelium.
Positive_regulation (induced) of Positive_regulation (increase) of PAF in esophageal epithelium associated with tetrodotoxin and antagonist
9) Confidence 0.37 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.07 Pain Relevance 0.47
Salivary levels of platelet activating factor (PAF) were measured together with serum CPK and interleukin 2 receptor in 30 patients admitted to the coronary care unit, 9 patients with pulmonary tuberculosis, 10 with acute severe asthma and 8 normal controls. 16 of the 30 C.C.U. patients had sustained a acute myocardial infarction (M.I.) 5 had acute angina and the remaining 9 had non cardiac chest pain.
Positive_regulation (measured) of Positive_regulation (levels) of platelet activating factor in chest associated with asthma, mycobacterial infection, angina and myocardial infarction
10) Confidence 0.04 Published 1994 Journal Thromb. Res. Section Abstract Doc Link 7992251 Disease Relevance 0.85 Pain Relevance 0.37

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