INT55476

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Context Info
Confidence 0.55
First Reported 1994
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.55
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGA2) plasma membrane (ITGA2)
Anatomy Link Frequency
platelet 5
7E3 2
spinal 1
ITGA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 3 100.00 Very High Very High Very High
cva 3 99.80 Very High Very High Very High
aspirin 9 99.66 Very High Very High Very High
Angina 12 98.40 Very High Very High Very High
epidural 3 97.92 Very High Very High Very High
backache 2 97.80 Very High Very High Very High
ischemia 1 60.08 Quite High
Disease Link Frequency Relevance Heat
Disease 1 99.60 Very High Very High Very High
Hemorrhage 6 99.10 Very High Very High Very High
Death 6 99.00 Very High Very High Very High
Myocardial Infarction 20 98.72 Very High Very High Very High
Cv General 3 Under Development 12 98.40 Very High Very High Very High
Spinal Epidural Hematoma 2 98.14 Very High Very High Very High
Low Back Pain 2 97.80 Very High Very High Very High
Neurologic Manifestations 1 96.92 Very High Very High Very High
Acute Coronary Syndrome 5 96.72 Very High Very High Very High
Thrombosis 1 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report a case of spontaneous spinal epidural hemorrhage with three unusual features: (1) the hemorrhage was associated with aspirin ingestion and a reduced level of platelet glycoprotein Ia/IIa; (2) the patient presented with typical severe back pain but without neurologic dysfunction; and (3) the patient initially recovered without surgical decompression but suffered from recurrent epidural hematoma.
Negative_regulation (reduced) of platelet glycoprotein in spinal associated with aspirin, spinal epidural hematoma, epidural, cva, neurologic manifestations and backache
1) Confidence 0.55 Published 1994 Journal Arch. Intern. Med. Section Abstract Doc Link 7993163 Disease Relevance 0.63 Pain Relevance 0.49
To evaluate the safety and efficacy of tirofiban, a specific inhibitor of the platelet glycoprotein llb/llla receptor, in the treatment of unstable angina and myocardial infarction without persistent ST elevation (acute coronary syndrome, ACS), a total of 200 patients were randomly assigned to a heparin group and a tirofiban+heparin group on double-blind basis and the treatment effects of the two protocols on ACS were compared when the patients of both groups were taking aspirin at the same time.
Negative_regulation (inhibitor) of platelet glycoprotein in platelet associated with aspirin, acute coronary syndrome, angina and myocardial infarction
2) Confidence 0.55 Published 2007 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 17497280 Disease Relevance 0.55 Pain Relevance 0.17
Among these drugs, low molecular weight heparins (for subcutaneous administration) and inhibitors of platelet glycoprotein receptor IIb/IIIa (for intravenous, and possibly oral, administration) are the most promising and are now under extensive investigation.
Negative_regulation (inhibitors) of platelet glycoprotein receptor in platelet
3) Confidence 0.39 Published 1999 Journal Int. J. Cardiol. Section Abstract Doc Link 10328613 Disease Relevance 0.31 Pain Relevance 0.20
Selective inhibition of the platelet glycoprotein (GP) IIb/ IIIa surface receptor is a potent mechanism to inhibit platelet aggregation and thrombus formation.
Negative_regulation (inhibition) of platelet glycoprotein in platelet associated with thrombosis
4) Confidence 0.10 Published 1998 Journal Am. J. Cardiol. Section Abstract Doc Link 9809890 Disease Relevance 0.25 Pain Relevance 0.04
Platelet glycoprotein (GP) IIb/IIIa receptor antagonists, which interrupt the final common pathway of platelet aggregation, have been proved to reduce the 30-day incidence of death, acute myocardial infarction (MI), and urgent revascularization in both high-risk and low-risk patients undergoing percutaneous intervention procedures.
Negative_regulation (reduce) of Platelet glycoprotein in platelet associated with antagonist, myocardial infarction and death
5) Confidence 0.10 Published 1998 Journal Ann Emerg Med Section Abstract Doc Link 9832669 Disease Relevance 1.00 Pain Relevance 0.12
The era of platelet glycoprotein (GP) IIb/IIIa receptor inhibition in cardiology was inaugurated in 1994 with the publication of the Evaluation of 7E3 for the Prevention of Ischemic Complications (EPIC) trial results.
Negative_regulation (inhibition) of platelet glycoprotein in 7E3
6) Confidence 0.04 Published 1998 Journal Am. Heart J. Section Abstract Doc Link 9539495 Disease Relevance 0.32 Pain Relevance 0.07
The era of platelet glycoprotein (GP) IIb/IIIa receptor inhibition in cardiology was inaugurated in 1994 with the publication of the Evaluation of 7E3 for the Prevention of Ischemic Complications (EPIC) trial results.
Negative_regulation (inhibition) of platelet glycoprotein in 7E3
7) Confidence 0.03 Published 1998 Journal Eur. Heart J. Section Abstract Doc Link 9597518 Disease Relevance 0.32 Pain Relevance 0.07
Synthetic inhibitors of platelet glycoprotein IIb/IIIa in clinical development.
Negative_regulation (inhibitors) of platelet glycoprotein in platelet associated with cva
8) Confidence 0.03 Published 2000 Journal Circulation Section Title Doc Link 10673265 Disease Relevance 0.17 Pain Relevance 0.17

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