INT55500

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Context Info
Confidence 0.36
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.42
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 1
respiratory 1
Coq10a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antiarrhythmic agent 2 79.48 Quite High
lidocaine 1 74.72 Quite High
depression 3 74.12 Quite High
fibrosis 12 46.76 Quite Low
adenocard 3 14.88 Low Low
ischemia 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 24 87.20 High High
Hepatotoxicity 15 76.32 Quite High
Acidosis 3 75.32 Quite High
Depression 3 74.12 Quite High
Cirrhosis 18 49.88 Quite Low
Death 6 47.76 Quite Low
Fibrosis 9 46.76 Quite Low
Necrosis 6 28.36 Quite Low
Liver Disease 6 5.00 Very Low Very Low Very Low
Myalgia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is observed that administration of L-carnitine or/and coenzyme Q10 significantly decreased serum ALT and AST activities.
Localization (decreased) of coenzyme Q10
1) Confidence 0.36 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.15 Pain Relevance 0.04
In accordance with these findings, Sumimoto et al. [16] found that ischemically damaged liver that was pretreated with CoQ10 showed an increase in levels of total protein to the normal range.
Localization (pretreated) of CoQ10 in liver
2) Confidence 0.36 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.27 Pain Relevance 0.03
After treatment, significantly decreased in the two enzymes activities compared to CCl4 control group as shown in Table 1 the percentages of improvement were 26.94%, 56.12% and 56.7 % (ALT) 26.69%, 31.13% and 36.15 % (AST) on injection of L-carnitine, coenzyme Q10 and their combination respectively.
Localization (decreased) of coenzyme Q10
3) Confidence 0.36 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0 Pain Relevance 0
The site of inhibition of BRB-I-28 and its derivatives on the respiratory chain was localized between flavoprotein n (FPn) and CoQ, which is similar to the effect of rotenone and several other antiarrhythmic drugs such as amiodarone, propranolol, etc.
Localization (localized) of CoQ in respiratory
4) Confidence 0.01 Published 1994 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 7994564 Disease Relevance 0 Pain Relevance 0.15

General Comments

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