INT55511

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Context Info
Confidence 0.49
First Reported 1994
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.19
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Ripk2) kinase activity (Ripk2) cytoplasm (Ripk2)
Ripk2 (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 4 99.70 Very High Very High Very High
agonist 10 99.20 Very High Very High Very High
Endogenous opioid 2 97.20 Very High Very High Very High
antagonist 6 87.76 High High
narcan 4 86.04 High High
Cholecystokinin 4 75.76 Quite High
MU agonist 4 75.00 Quite High
antinociception 2 75.00 Quite High
Enkephalin 8 67.04 Quite High
Antinociceptive 4 64.72 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 2 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these findings suggest that the potentiating effects of delta agonists on mu-mediated analgesia are due to an increase in the release of endogenous CCK interacting with CCK-A and CCK-B receptors and resulting in positive and negative regulation of the endogenous opioid system.
Positive_regulation (increase) of CCK Binding (interacting) of associated with endogenous opioid, agonist and analgesia
1) Confidence 0.49 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996417 Disease Relevance 0.09 Pain Relevance 0.85
Taken together, these findings suggest that the potentiating effects of delta agonists on mu-mediated analgesia are due to an increase in the release of endogenous CCK interacting with CCK-A and CCK-B receptors and resulting in positive and negative regulation of the endogenous opioid system.
Positive_regulation (increase) of CCK Binding (interacting) of associated with endogenous opioid, agonist and analgesia
2) Confidence 0.49 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996417 Disease Relevance 0.09 Pain Relevance 0.85

General Comments

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