INT55516

Context Info Confidence 0.60 First Reported 1994 Last Reported 2007 Negated 2 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 0.83 Pain Relevance 3.58

endoplasmic reticulum (Cyp2d1) cytoplasm (Cyp2d1)

Anatomy Link Frequency brain 1 Cyp2d1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Morphine 8 99.66 Codeine 18 99.42 ischemia 10 97.24 Oxycodone 16 97.04 Analgesic 2 91.44 Potency 2 90.64 Neurotransmitter 14 81.04 analgesia 18 76.80 Opioid 2 75.00 nMDA receptor antagonist 6 73.48

Disease Link Frequency Relevance Heat Cv Unclassified Under Development 8 97.24 Renal Disease 2 96.16 Reperfusion Injury 1 93.12 Disorders Of Creatine Metabolism 4 92.52 Depression 4 64.24 Sprains And Strains 2 59.44 Death 5 46.12 Parkinson's Disease 13 45.28 Disease 133 33.44 Necrosis 2 29.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the Sprague-Dawley (SD) rat, the O-demethylation of codeine to morphine is catalyzed by cytochrome P4502D1 (CYP2D1), which is absent in the female Dark Agouti (DA) rat.

Neg (absent) Gene_expression (absent) of cytochrome P4502D1 associated with morphine and codeine

1) Confidence 0.60 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996467 Disease Relevance 0.06 Pain Relevance 1.66

In the Sprague-Dawley (SD) rat, the O-demethylation of codeine to morphine is catalyzed by cytochrome P4502D1 (CYP2D1), which is absent in the female Dark Agouti (DA) rat.

Neg (absent) Gene_expression (absent) of CYP2D1 associated with morphine and codeine

2) Confidence 0.60 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996467 Disease Relevance 0.06 Pain Relevance 1.66

Studies have shown that memantine produces minimal inhibition of CYP450 enzymes CYP1A2, CYP2A6, CYP2C9, CYP2D6, CYP2E1, and CYP3A4, indicating that no pharmacokinetic interactions with drugs metabolized by these enzymes are expected.

Gene_expression (produces) of CYP2C9

3) Confidence 0.01 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654628 Disease Relevance 0.18 Pain Relevance 0.03

As such CYP2C9 would likely produce physiologically relevant levels of reactive oxygen species in the brain if it is located there.

Gene_expression (produce) of CYP2C9 in brain

4) Confidence 0.01 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654794 Disease Relevance 0.35 Pain Relevance 0.19

Memantine does not induce the cytochrome P450 isozymes CYP1A2, CYP2C9, CYP2E1, and CYP3A4/5 (Forest Laboratories 2003).

Gene_expression (isozymes) of CYP2C9

5) Confidence 0.01 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654628 Disease Relevance 0.19 Pain Relevance 0.04

General Comments

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