INT55516

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Context Info
Confidence 0.60
First Reported 1994
Last Reported 2007
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.83
Pain Relevance 3.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp2d1) cytoplasm (Cyp2d1)
Anatomy Link Frequency
brain 1
Cyp2d1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 8 99.66 Very High Very High Very High
Codeine 18 99.42 Very High Very High Very High
ischemia 10 97.24 Very High Very High Very High
Oxycodone 16 97.04 Very High Very High Very High
Analgesic 2 91.44 High High
Potency 2 90.64 High High
Neurotransmitter 14 81.04 Quite High
analgesia 18 76.80 Quite High
Opioid 2 75.00 Quite High
nMDA receptor antagonist 6 73.48 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 8 97.24 Very High Very High Very High
Renal Disease 2 96.16 Very High Very High Very High
Reperfusion Injury 1 93.12 High High
Disorders Of Creatine Metabolism 4 92.52 High High
Depression 4 64.24 Quite High
Sprains And Strains 2 59.44 Quite High
Death 5 46.12 Quite Low
Parkinson's Disease 13 45.28 Quite Low
Disease 133 33.44 Quite Low
Necrosis 2 29.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the Sprague-Dawley (SD) rat, the O-demethylation of codeine to morphine is catalyzed by cytochrome P4502D1 (CYP2D1), which is absent in the female Dark Agouti (DA) rat.
Neg (absent) Gene_expression (absent) of cytochrome P4502D1 associated with morphine and codeine
1) Confidence 0.60 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996467 Disease Relevance 0.06 Pain Relevance 1.66
In the Sprague-Dawley (SD) rat, the O-demethylation of codeine to morphine is catalyzed by cytochrome P4502D1 (CYP2D1), which is absent in the female Dark Agouti (DA) rat.
Neg (absent) Gene_expression (absent) of CYP2D1 associated with morphine and codeine
2) Confidence 0.60 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996467 Disease Relevance 0.06 Pain Relevance 1.66
Studies have shown that memantine produces minimal inhibition of CYP450 enzymes CYP1A2, CYP2A6, CYP2C9, CYP2D6, CYP2E1, and CYP3A4, indicating that no pharmacokinetic interactions with drugs metabolized by these enzymes are expected.
Gene_expression (produces) of CYP2C9
3) Confidence 0.01 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654628 Disease Relevance 0.18 Pain Relevance 0.03
As such CYP2C9 would likely produce physiologically relevant levels of reactive oxygen species in the brain if it is located there.
Gene_expression (produce) of CYP2C9 in brain
4) Confidence 0.01 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654794 Disease Relevance 0.35 Pain Relevance 0.19
Memantine does not induce the cytochrome P450 isozymes CYP1A2, CYP2C9, CYP2E1, and CYP3A4/5 (Forest Laboratories 2003).
Gene_expression (isozymes) of CYP2C9
5) Confidence 0.01 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654628 Disease Relevance 0.19 Pain Relevance 0.04

General Comments

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