INT55529

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 7.91
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Gba) carbohydrate metabolic process (Gba) lipid metabolic process (Gba)
lysosome (Gba)
Anatomy Link Frequency
macrophages 3
monocytes 2
liver 1
bone marrow 1
fibroblasts 1
Gba (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 17 100.00 Very High Very High Very High
Bile 3 99.84 Very High Very High Very High
Calcium channel 9 99.58 Very High Very High Very High
Pain 13 88.80 High High
Central nervous system 8 84.00 Quite High
antagonist 4 30.32 Quite Low
tolerance 2 25.00 Low Low
Potency 4 5.00 Very Low Very Low Very Low
TRP channel 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lipidosis 2 99.78 Very High Very High Very High
Gauchers Disease 51 99.76 Very High Very High Very High
Disease 45 99.48 Very High Very High Very High
Lysosomal Storage Diseases 25 99.06 Very High Very High Very High
Sprains And Strains 8 93.08 High High
Hepatomegaly 1 91.12 High High
Congenital Anomalies 11 90.72 High High
Splenomegaly 6 90.08 High High
Hepatotoxicity 3 89.52 High High
Anaemia 1 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gaucher disease is a disorder of sphingolipid metabolism resulting from an inherited deficiency of the lysosomal hydrolase glucocerebrosidase.
Negative_regulation (deficiency) of glucocerebrosidase associated with gauchers disease
1) Confidence 0.59 Published 2007 Journal Mol. Genet. Metab. Section Abstract Doc Link 17079175 Disease Relevance 0.81 Pain Relevance 0.09
In Gaucher disease, a genetic deficiency in the activity of the lysosomal enzyme beta-glucocerebrosidase (acid beta-glucosidase) causes monocytes and macrophages to store excessive amounts of glucocerebroside in lysosomes.
Negative_regulation (deficiency) of acid beta-glucosidase in monocytes associated with gauchers disease
2) Confidence 0.57 Published 2002 Journal Br J Radiol Section Abstract Doc Link 12036828 Disease Relevance 0.49 Pain Relevance 0.07
In Gaucher disease, a genetic deficiency in the activity of the lysosomal enzyme beta-glucocerebrosidase (acid beta-glucosidase) causes monocytes and macrophages to store excessive amounts of glucocerebroside in lysosomes.
Negative_regulation (deficiency) of beta-glucocerebrosidase in monocytes associated with gauchers disease
3) Confidence 0.51 Published 2002 Journal Br J Radiol Section Abstract Doc Link 12036828 Disease Relevance 0.48 Pain Relevance 0.07
Gaucher's disease is a lipidosis caused by deficiency of the enzyme glucocerebrosidase (glucosylceramidase) with secondary accumulation of glucocerebrosides in macrophage lysosomes.
Negative_regulation (deficiency) of glucocerebrosidase in macrophage associated with disease and lipidosis
4) Confidence 0.48 Published 1993 Journal Minerva Med. Section Abstract Doc Link 8492969 Disease Relevance 0.53 Pain Relevance 0.04
We show that expression of Cre-recombinase in cells of hematopoietic and endothelial origin results in deficiency of glucocerebrosidase in the liver, spleen, bone marrow, and peripheral white cells.
Negative_regulation (deficiency) of glucocerebrosidase in bone marrow
5) Confidence 0.43 Published 2007 Journal Mol. Genet. Metab. Section Abstract Doc Link 17079175 Disease Relevance 0.85 Pain Relevance 0.06
In Gaucher disease, a genetic deficiency in the activity of the lysosomal enzyme beta-glucocerebrosidase (acid beta-glucosidase) causes monocytes and macrophages to store excessive amounts of glucocerebroside in lysosomes.
Negative_regulation (deficiency) of acid beta-glucosidase in macrophages associated with gauchers disease
6) Confidence 0.19 Published 2002 Journal Br J Radiol Section Abstract Doc Link 12036828 Disease Relevance 0.49 Pain Relevance 0.07
In Gaucher disease, a genetic deficiency in the activity of the lysosomal enzyme beta-glucocerebrosidase (acid beta-glucosidase) causes monocytes and macrophages to store excessive amounts of glucocerebroside in lysosomes.
Negative_regulation (deficiency) of beta-glucocerebrosidase in macrophages associated with gauchers disease
7) Confidence 0.17 Published 2002 Journal Br J Radiol Section Abstract Doc Link 12036828 Disease Relevance 0.48 Pain Relevance 0.07
Gaucher disease is a sphingolipid storage disorder caused by a deficiency of the lysosomal enzyme glucocerebrosidase (GC) and the consequent deposition of glucocerebrosides into the cells of the macrophagic system.
Negative_regulation (deficiency) of glucocerebrosidase associated with gauchers disease
8) Confidence 0.16 Published 1994 Journal Medicina (B Aires) Section Abstract Doc Link 7997130 Disease Relevance 0.73 Pain Relevance 0.08
We show that expression of Cre-recombinase in cells of hematopoietic and endothelial origin results in deficiency of glucocerebrosidase in the liver, spleen, bone marrow, and peripheral white cells.
Negative_regulation (deficiency) of glucocerebrosidase in liver
9) Confidence 0.15 Published 2007 Journal Mol. Genet. Metab. Section Abstract Doc Link 17079175 Disease Relevance 0.85 Pain Relevance 0.06
We show that expression of Cre-recombinase in cells of hematopoietic and endothelial origin results in deficiency of glucocerebrosidase in the liver, spleen, bone marrow, and peripheral white cells.
Negative_regulation (deficiency) of glucocerebrosidase in spleen
10) Confidence 0.15 Published 2007 Journal Mol. Genet. Metab. Section Abstract Doc Link 17079175 Disease Relevance 0.85 Pain Relevance 0.06
The most prevalent LSD is Gaucher disease (GD), which is caused by a deficiency in the activity of lysosomal glucocerebrosidase (GC), a glycolipid hydrolase [7].
Negative_regulation (deficiency) of glucocerebrosidase associated with gauchers disease and lysosomal storage diseases
11) Confidence 0.12 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 1.10 Pain Relevance 0.16
In its absence, sufficient hepatic accumulation occurs to redirect some of the APAP-GLUC to bile.
Negative_regulation (redirect) of APAP-GLUC in bile associated with bile and paracetamol
12) Confidence 0.06 Published 2005 Journal Hepatology Section Abstract Doc Link 16250050 Disease Relevance 0.20 Pain Relevance 1.19
It has recently been reported that diltiazem and verapamil, known calcium channel blockers, partially restored mutant glucocerebrosidase folding, trafficking, and enzyme function in patient fibroblasts [32].
Negative_regulation (restored) of glucocerebrosidase in fibroblasts associated with calcium channel
13) Confidence 0.04 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2995157 Disease Relevance 0.05 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox