INT55552

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Context Info
Confidence 0.59
First Reported 1994
Last Reported 2008
Negated 2
Speculated 3
Reported most in Abstract
Documents 5
Total Number 12
Disease Relevance 5.93
Pain Relevance 4.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Nr3c2) nucleus (Nr3c2) cytoplasm (Nr3c2)
Anatomy Link Frequency
hippocampus 4
Nr3c2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
noradrenaline 10 99.72 Very High Very High Very High
Neurotransmitter 6 99.48 Very High Very High Very High
5HT 16 99.26 Very High Very High Very High
Serotonin 2 99.16 Very High Very High Very High
Hippocampus 207 98.76 Very High Very High Very High
antidepressant 24 98.16 Very High Very High Very High
fluoxetine 10 97.68 Very High Very High Very High
monoamine 4 96.36 Very High Very High Very High
Limbic system 1 93.20 High High
Neuropeptide 1 91.44 High High
Disease Link Frequency Relevance Heat
Stress 378 99.72 Very High Very High Very High
Post-traumatic Stress Disorder 189 99.20 Very High Very High Very High
Syndrome 14 95.60 Very High Very High Very High
Congenital Anomalies 7 91.20 High High
Attention Deficit Hyperactivity Disorder 6 88.52 High High
Aging 1 87.84 High High
Death 21 82.60 Quite High
Depression 16 77.68 Quite High
Mental Disorders 7 74.56 Quite High
Traumatic Stress Disorders 14 72.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, previous studies also suggest different regulation patterns in MR and GR expression with decreased MR/GR ratio in PTSD.
Regulation (regulation) of Gene_expression (expression) of MR associated with post-traumatic stress disorder
1) Confidence 0.59 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.42 Pain Relevance 0.10
In the present study, we performed immunohistochemistry and western blotting to examine the changes in hippocampal MR- and GR-expression after SPS.
Spec (examine) Regulation (changes) of Gene_expression (expression) of MR associated with stress
2) Confidence 0.52 Published 2008 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2532603 Disease Relevance 1.42 Pain Relevance 0.13
It is not known whether homodimers, heterodimers, or both caused the decreased expression of MR and GR.
Spec (whether) Regulation (caused) of Gene_expression (expression) of MR
3) Confidence 0.43 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.50 Pain Relevance 0.11
Changes of MR and GR expression in the hippocampal region between control and SPS rats are presented in Figure 3.
Regulation (Changes) of Gene_expression (expression) of MR associated with stress
4) Confidence 0.43 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.73 Pain Relevance 0.10
We found altered MR/GR ratio of both CA1-subregion and all hippocampus in the SPS animals.
Regulation (altered) of Gene_expression (ratio) of MR/GR in hippocampus associated with stress and hippocampus
5) Confidence 0.43 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.87 Pain Relevance 0.45
Selective effects on NGFI-A, MR, GR and NGFI-B hippocampal mRNA expression after chronic treatment with different subclasses of antidepressants in the rat.
Regulation (effects) of Gene_expression (expression) of MR associated with antidepressant
6) Confidence 0.36 Published 2000 Journal Psychopharmacology (Berl.) Section Title Doc Link 10958110 Disease Relevance 0 Pain Relevance 0.28
Interestingly, previous studies also suggest different regulation patterns in MR and GR expression with decreased MR/GR ratio in PTSD.
Regulation (patterns) of Gene_expression (expression) of MR associated with post-traumatic stress disorder
7) Confidence 0.26 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.42 Pain Relevance 0.10
In general, SPS induced down-regulation of MR- and GR-expression.
Regulation (regulation) of Gene_expression (expression) of MR associated with stress
8) Confidence 0.23 Published 2008 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2532603 Disease Relevance 1.24 Pain Relevance 0.12
The GR and MR levels and biosynthesis appear to be under a serotoninergic and, to a lesser extent, a noradrenergic, cholinergic and dopaminergic influence.
Regulation (under) of Gene_expression (biosynthesis) of MR
9) Confidence 0.13 Published 1994 Journal Pol J Pharmacol Section Abstract Doc Link 8000453 Disease Relevance 0 Pain Relevance 0.40
Fluoxetine treatment increased GR mRNA in the hippocampus of young rats (24 and 46% increase in DG and CA3, respectively, P<0.01) but had no effect on hippocampal MR mRNA expression.
Neg (no) Regulation (effect) of Gene_expression (expression) of MR mRNA in hippocampus associated with hippocampus and fluoxetine
10) Confidence 0.12 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12393271 Disease Relevance 0.09 Pain Relevance 0.66
Treatment with NA for 4 days also increased glucocorticoid receptor expression but had no effect on mineralocorticoid receptor expression.
Neg (no) Regulation (effect) of Gene_expression (expression) of mineralocorticoid receptor associated with noradrenaline
11) Confidence 0.02 Published 2003 Journal Neuroscience Section Abstract Doc Link 12732243 Disease Relevance 0 Pain Relevance 1.24
We examined whether serotonin (5HT) and noradrenaline (NA) have direct effects on glucocorticoid receptor and mineralocorticoid receptor expression in primary hippocampal neurones, and whether antidepressants also exert direct effects on target neurones.
Spec (whether) Regulation (effects) of Gene_expression (expression) of mineralocorticoid receptor associated with antidepressant, noradrenaline, 5ht and serotonin
12) Confidence 0.02 Published 2003 Journal Neuroscience Section Abstract Doc Link 12732243 Disease Relevance 0.24 Pain Relevance 0.84

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