INT55562

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Context Info
Confidence 0.31
First Reported 1994
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.44
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (IFNAR2) extracellular space (IFNAR2) extracellular region (IFNAR2)
plasma membrane (IFNAR2)
Anatomy Link Frequency
blood 1
brain 1
endocrine system 1
IFNAR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 10 98.98 Very High Very High Very High
Pain 2 78.88 Quite High
Central nervous system 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Viral Infection 2 86.56 High High
Pain 2 78.88 Quite High
Hematologic Neoplasms 2 53.44 Quite High
Autoimmune Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The different IFNs are classified into three classes: alpha, beta, and gamma. alpha-IFN produced in the brain exerts direct effects on the brain and endocrine system by activating the neurosecretory hypothalamic neurons and regulates the hypothalamic-pituitary-adrenocortical axis.
Gene_expression (produced) of alpha-IFN in endocrine system
1) Confidence 0.31 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16226745 Disease Relevance 0.22 Pain Relevance 0.15
To determine elimination, the femoral artery and vein were cannulated. 24 h later, the conscious rat was given lidocaine through the venous catheter and blood was drawn from the arterial catheter for lidocaine determination every 3 min for 20 min. 7 rats were pre-treated with intramuscular rat alpha-IFN 7.5 x 10(5) U, 24 h prior to the experiment and another 4 rats were given saline i.m.
Gene_expression (pre-treated) of alpha-IFN in blood associated with lidocaine
2) Confidence 0.17 Published 1994 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 8001595 Disease Relevance 0 Pain Relevance 0.68
The different IFNs are classified into three classes: alpha, beta, and gamma. alpha-IFN produced in the brain exerts direct effects on the brain and endocrine system by activating the neurosecretory hypothalamic neurons and regulates the hypothalamic-pituitary-adrenocortical axis.
Gene_expression (produced) of alpha-IFN in brain
3) Confidence 0.11 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16226745 Disease Relevance 0.22 Pain Relevance 0.15

General Comments

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