INT55564

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Context Info
Confidence 0.01
First Reported 1994
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprk1, Pde6b) plasma membrane (Oprk1) signal transducer activity (Oprk1)
Anatomy Link Frequency
brain 1
Oprk1 (Mus musculus)
Pde6b (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 8 100.00 Very High Very High Very High
agonist 6 100.00 Very High Very High Very High
opioid receptor 1 98.20 Very High Very High Very High
Antinociceptive 4 78.00 Quite High
Potency 2 72.08 Quite High
Morphine 4 67.12 Quite High
fortral 1 66.32 Quite High
butorphanol 1 65.04 Quite High
narcan 4 51.68 Quite High
Pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In an opioid receptor binding assay with a guinea pig brain membrane fraction, R-84760 showed a 5 times higher affinity for the kappa-opioid receptor than CI-977, the most potent reference kappa-opioid receptor agonist, and selectivity of R-84760 for the kappa-opioid receptor was higher than that of U-69593, a highly selective kappa-opioid receptor agonist.
kappa-opioid receptor Binding (affinity) of R-84760 in brain associated with agonist, kappa opioid receptor and opioid receptor
1) Confidence 0.01 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8001635 Disease Relevance 0 Pain Relevance 0.92

General Comments

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