INT55566

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Context Info
Confidence 0.36
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.13
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Dct) isomerase activity (Dct) cytosol (Dct)
oxidoreductase activity (Dct) cytoplasm (Dct)
Anatomy Link Frequency
spike 1
immune system 1
melanocyte 1
melanoblasts 1
Dct (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 1 100.00 Very High Very High Very High
diclofenac 140 98.70 Very High Very High Very High
melanocortin 1 receptor 59 80.96 Quite High
agonist 8 73.88 Quite High
cINOD 34 35.84 Quite Low
Central nervous system 4 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microphthalmia 15 95.70 Very High Very High Very High
Hypersensitivity 28 86.20 High High
Skin Cancer 11 80.48 Quite High
Nevus 1 77.68 Quite High
Apoptosis 5 71.68 Quite High
Anaemia 1 43.60 Quite Low
Immunization 2 33.44 Quite Low
Vibrio Infection 6 19.92 Low Low
Death 11 5.00 Very Low Very Low Very Low
Sprains And Strains 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of a beta-endorphin cleavage product devoid of opioid effects, des-tyrosine-gamma-endorphin (DT gamma E) on the neocortical spike-and-wave spindling episodes in the electrocorticogram (ECoG) of DBA/2J mice was studied.
Gene_expression (product) of DT gamma E in spike associated with opioid
1) Confidence 0.36 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8001646 Disease Relevance 0 Pain Relevance 0.10
It promotes transcription of melanocyte-specific gene products including melanosomal enzymes tyrosinase, TYRP1 and DCT and the matrix protein SILV/PMEL (Levy et al., 2006).
Gene_expression (products) of DCT in melanocyte
2) Confidence 0.26 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0.18 Pain Relevance 0.38
Melan-a cells treated with ASIP lose expression of TYRP1, DCT, and SILV/PMEL, all needed to generate normal eumelanosomes but not pheomelanosomes, while retaining low tyrosinase expression (Sakai et al., 1997) which would favor pheomelanogenesis (Ito, 2003).
Gene_expression (expression) of DCT
3) Confidence 0.23 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.08
Within melanoblasts, Mitf promotes a) cell-cycle exit, by activating expression of the p21WAF1, a cyclin-dependent kinase inhibitor [9], b) cell survival, by upregulating the expression of BCL2 [10], and c) melanin synthesis, by activating expression of Tyrosinase (Tyr), Tyrosinase-related protein 1 (Tyrp1), and Tyrosinase-related protein 2 (Tyrp2, also known as Dopachrome tautomerase, Dct) [11]–[14].
Gene_expression (expression) of Tyrp2 in melanoblasts associated with microphthalmia
4) Confidence 0.15 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2940735 Disease Relevance 0.67 Pain Relevance 0
As basophils have been recently shown to be key players in the immune system [32], we investigated DF/DF5der/DF-metabolite-specific IgE bound on patients' basophils by BAT and sLT production.
Gene_expression (production) of sLT in immune system associated with diclofenac
5) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965666 Disease Relevance 0.27 Pain Relevance 0.38

General Comments

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