INT55578

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Context Info
Confidence 0.62
First Reported 1994
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 7
Total Number 10
Disease Relevance 4.74
Pain Relevance 5.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
brain 6
spinal cord 2
neurons 2
neutrophil 2
Il1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 19 100.00 Very High Very High Very High
cytokine 13 100.00 Very High Very High Very High
electroacupuncture 12 100.00 Very High Very High Very High
Hyperalgesia 7 100.00 Very High Very High Very High
allodynia 4 100.00 Very High Very High Very High
Thermal hyperalgesia 4 100.00 Very High Very High Very High
Spinal cord 3 100.00 Very High Very High Very High
noradrenaline 20 99.96 Very High Very High Very High
Neuropathic pain 9 99.68 Very High Very High Very High
Morphine 5 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 16 100.00 Very High Very High Very High
Neuropathic Pain 16 100.00 Very High Very High Very High
Hyperalgesia 11 100.00 Very High Very High Very High
Ganglion Cysts 2 97.84 Very High Very High Very High
Injury 27 97.80 Very High Very High Very High
Nervous System Injury 1 93.80 High High
Pain 3 93.40 High High
Cognitive Disorder 12 91.04 High High
Inflammatory Pain 3 89.28 High High
Adhesions 1 84.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alteration of IL-1 beta expression by exogenous factors, such as morphine, may affect the neuro-endocrine-immune axis.
Regulation (Alteration) of Gene_expression (expression) of IL-1 beta associated with morphine
1) Confidence 0.62 Published 1996 Journal Brain Res. Section Abstract Doc Link 8814911 Disease Relevance 0 Pain Relevance 0.57
Betamethasone may act by regulating the expression of NF-kappaB, TNFalpha, IL-1beta and IL-10 in the brain.
Regulation (regulating) of Gene_expression (expression) of IL-1beta in brain
2) Confidence 0.44 Published 2006 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 16501235 Disease Relevance 0.84 Pain Relevance 0.88
This study aimed to determine the effect of sirolimus on hyperalgesia and allodynia and on serum and spinal cord TNF-alpha, IL-1beta and IL-6 levels in rat neuropathic pain.
Spec (determine) Regulation (effect) of Gene_expression (levels) of IL-1beta in spinal cord associated with hyperalgesia, allodynia, neuropathic pain and spinal cord
3) Confidence 0.44 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20600616 Disease Relevance 1.17 Pain Relevance 1.25
Kainic acid up-regulated the expression of the inflammatory cytokines IL-1beta and TNF-alpha, the neurotrophic factor IGF-1, and the transcription factor NF-kappaB.
Regulation (regulated) of Gene_expression (expression) of IL-1beta associated with inflammation and cytokine
4) Confidence 0.44 Published 2008 Journal Nutr Neurosci Section Abstract Doc Link 18681986 Disease Relevance 0.70 Pain Relevance 0.53
The purpose of this study was to investigate whether an intraperitoneal injection of interleukin-1 beta (IL-1 beta) affects noradrenaline release in the spleen through its action on the brain of conscious rats.
Spec (whether) Regulation (affects) of Spec (whether) Gene_expression (injection) of IL-1 beta in brain associated with noradrenaline
5) Confidence 0.44 Published 1994 Journal Brain Behav. Immun. Section Abstract Doc Link 8003768 Disease Relevance 0 Pain Relevance 0.28
The purpose of this study was to investigate whether an intraperitoneal injection of interleukin-1 beta (IL-1 beta) affects noradrenaline release in the spleen through its action on the brain of conscious rats.
Spec (whether) Regulation (affects) of Gene_expression (injection) of interleukin-1 beta in brain associated with noradrenaline
6) Confidence 0.44 Published 1994 Journal Brain Behav. Immun. Section Abstract Doc Link 8003768 Disease Relevance 0 Pain Relevance 0.28
Effects of complete Freund's adjuvant on immunohistochemical distribution of IL-1beta and IL-1R I in neurons and glia cells of dorsal root ganglion.
Regulation (Effects) of Gene_expression (distribution) of IL-1beta in neurons associated with ganglion cysts and dorsal root ganglion
7) Confidence 0.32 Published 2005 Journal Acta Pharmacol. Sin. Section Title Doc Link 15663898 Disease Relevance 0.29 Pain Relevance 0.28
The present study was designed to evaluate the effects of EA and antisense oligodeoxynucleotide (ODN) to IL-1 receptor type I (IL-1RI) on carrageenan-induced thermal hyperalgesia and the expression of IL-1beta as well as IL-1RI.
Regulation (effects) of Gene_expression (expression) of IL-1beta associated with thermal hyperalgesia and electroacupuncture
8) Confidence 0.12 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19022353 Disease Relevance 0.62 Pain Relevance 1.16
Fucoidin had no effect on carrageenan-induced TNF-alpha, IL-1beta, and cytokine-induced neutrophil chemoattractant 1 (CINC-1)/CXCL1 production, suggesting that neutrophils were not the source of hypernociceptive cytokines.
Neg (no) Regulation (effect) of Gene_expression (production) of IL-1beta in neutrophil associated with cytokine
9) Confidence 0.09 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18203872 Disease Relevance 0.47 Pain Relevance 0.32
Western blot analysis showed no significant change in IL-1b levels in the hippocamppi of CCI-treated rats receiving post-injury treatments of either saline or MINO plus NAC (saline, 1.0±1.9 (n?
Neg (no) Regulation (change) of Gene_expression (levels) of IL-1b associated with injury
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2930858 Disease Relevance 0.67 Pain Relevance 0

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