INT55582

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Context Info
Confidence 0.13
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.56
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Hpse) extracellular region (Hpse) cell adhesion (Hpse)
nucleus (Hpse) carbohydrate metabolic process (Hpse) lysosome (Hpse)
Anatomy Link Frequency
neurons 2
pituitary 2
Hpse (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 1 90.08 High High
antagonist 41 85.36 High High
narcan 2 82.72 Quite High
cytokine 23 82.24 Quite High
Endogenous opioid 1 80.48 Quite High
agonist 23 79.04 Quite High
Intracerebroventricular 2 66.00 Quite High
opioid receptor 3 48.72 Quite Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
Inflammation 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nutritional Deficiencies 1 93.12 High High
Stress 48 92.36 High High
Neuroblastoma 2 70.80 Quite High
Pressure And Volume Under Development 1 54.32 Quite High
Obesity 4 36.32 Quite Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Starvation 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These electrophysiological data suggest that the decreases in HPA activity evoked by IFN-alpha are mediated by a rapid inhibitory effect at the level of the corticotropin-releasing factor-secreting neurons.
Positive_regulation (mediated) of Negative_regulation (decreases) of HPA in neurons
1) Confidence 0.13 Published 1994 Journal Brain Behav. Immun. Section Abstract Doc Link 8003770 Disease Relevance 0.07 Pain Relevance 0.32
At the pituitary level, the negative interrelation of the HPA and HPG axis may be mediated by the paracrine negative signals of ?
Positive_regulation (mediated) of Negative_regulation (interrelation) of HPA in pituitary
2) Confidence 0.04 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.49 Pain Relevance 0

General Comments

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