INT55583

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Context Info
Confidence 0.78
First Reported 1994
Last Reported 2011
Negated 3
Speculated 1
Reported most in Body
Documents 135
Total Number 138
Disease Relevance 85.07
Pain Relevance 24.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 8
macrophages 3
brain 2
NK cells 2
neuronal 2
IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2221 100.00 Very High Very High Very High
Inflammation 1678 100.00 Very High Very High Very High
rheumatoid arthritis 1569 100.00 Very High Very High Very High
Paracetamol 491 99.98 Very High Very High Very High
Central nervous system 458 99.90 Very High Very High Very High
Multiple sclerosis 1527 99.80 Very High Very High Very High
fibrosis 87 99.78 Very High Very High Very High
Arthritis 516 99.74 Very High Very High Very High
Neuritis 3 99.54 Very High Very High Very High
spinal inflammation 53 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1826 100.00 Very High Very High Very High
Rheumatoid Arthritis 1572 100.00 Very High Very High Very High
Cancer 897 100.00 Very High Very High Very High
Toxicity 179 100.00 Very High Very High Very High
Multiple Sclerosis 1761 99.80 Very High Very High Very High
Cirrhosis 152 99.78 Very High Very High Very High
Demyelinating Disease 252 99.76 Very High Very High Very High
Arthritis 435 99.74 Very High Very High Very High
Systemic Lupus Erythematosus 953 99.68 Very High Very High Very High
Status Epilepticus 21 99.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AQP4 p21-40-primed T cells secreted both IFN-?
Localization (secreted) of IFN in T cells
1) Confidence 0.78 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2994828 Disease Relevance 0.78 Pain Relevance 0.07
T cells that recognized AQP4 p21-40 secreted IFN-?
Localization (secreted) of IFN in T cells
2) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.40 Pain Relevance 0
We have demonstrated that the IFN-alpha released from the nDS is functionally active on both host immune cells and a human melanoma cell line in vitro.
Localization (released) of IFN-alpha in immune cells associated with skin cancer
3) Confidence 0.78 Published 2005 Journal Biomed Microdevices Section Abstract Doc Link 15834523 Disease Relevance 0.71 Pain Relevance 0.06
Experimental data presented in this article, demonstrate an important regulatory function of IFN-?
Localization (function) of IFN
4) Confidence 0.73 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.88 Pain Relevance 0.63
For instance, apigenin and luteolin appear to regulate serine 727 phosphorylation of STAT1 at levels that are potentially conducive to apoptosis, all the while keeping a damper on levels in the presence of IFN-?
Localization (presence) of IFN associated with apoptosis
5) Confidence 0.73 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.56 Pain Relevance 0.20
It remains to be seen whether IFN-?
Localization (seen) of IFN
6) Confidence 0.73 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.97 Pain Relevance 0.87
M of either apigenin or luteolin in the presence of IFN-?
Localization (presence) of IFN
7) Confidence 0.73 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.18 Pain Relevance 0.07
signalling in limiting cartilage deterioration in early inflammatory arthritis; an outcome directed by IFN-?'
Localization (directed) of IFN in cartilage associated with inflammation and arthritis
8) Confidence 0.73 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 1.17 Pain Relevance 0.67
Co-administration of IFN-?
Localization (administration) of IFN
9) Confidence 0.73 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.64 Pain Relevance 0.46
Co-administration of IFN-?
Localization (administration) of IFN
10) Confidence 0.73 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.76 Pain Relevance 0.71
M of apigenin or luteolin in the presence of a stimulatory amount of IFN-?
Localization (amount) of IFN
11) Confidence 0.73 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.16 Pain Relevance 0
Consequently, the release of the Th1 associated cytokines IL-12, IFN-?
Localization (release) of IFN associated with cytokine
12) Confidence 0.68 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0.33 Pain Relevance 0.30
T cells were functionally characterized by antigen-dependent secretion of interferon (IFN)-gamma, interleukin (Il)-4, and IL-10, which indicate type 1, type 2, or regulatory T-cell responses, respectively.
Localization (secretion) of IFN in regulatory T-cell
13) Confidence 0.68 Published 2010 Journal Gastroenterology Section Body Doc Link 19931255 Disease Relevance 0.08 Pain Relevance 0
Studies showed that LF elevates the number and increases the activity of T and B lymphocytes and NK cells, stimulates the release of a number of cytokines (IL-1, -6, -8, -18, IFN-gamma, TNF alpha), increases phagocytic activity and cytotoxicity of monocytes/macrophages, accelerates the maturation of T and B cells, and elevates the expression of several types of cellular receptors, such as CD4, zeta chain of the CD3 complex, LFA-1, CD11, ICAM-1, and selectin P.
Localization (release) of IFN in macrophages associated with cytokine
14) Confidence 0.68 Published 2006 Journal Postepy Hig Med Dosw (Online) Section Abstract Doc Link 16885906 Disease Relevance 0.95 Pain Relevance 0.15
Little data was given for the control group and it is not clear why they did not receive IFN-?
Neg (not) Localization (receive) of IFN
15) Confidence 0.68 Published 2005 Journal BMC Pediatr Section Body Doc Link PMC1343569 Disease Relevance 0.12 Pain Relevance 0
Neuropsychiatric effects from IFN-?
Localization (effects) of IFN
16) Confidence 0.56 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656302 Disease Relevance 1.42 Pain Relevance 0.28
In all, 150 healthy men and women (aged 18-51 years) were randomly assigned to 1 of 3 groups: intranasal interferon (IFN)-alpha2b (6 x 10(6) U every 12 h x 3) plus oral chlorpheniramine (12 mg extended release) and ibuprofen (400 mg) every 12 h for 4.5 days (n=59 subjects); intranasal placebo plus oral chlorpheniramine and ibuprofen (n=61 subjects); or intranasal and oral placebos (n=30 subjects).
Localization (release) of IFN
17) Confidence 0.53 Published 2002 Journal J. Infect. Dis. Section Abstract Doc Link 12134249 Disease Relevance 0.47 Pain Relevance 0.06
The overall SVR rates for 24 and 48 weeks of therapy were 33% and 41%, respectively, for patients receiving IFN-?
Localization (receiving) of IFN in SVR
18) Confidence 0.51 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC2990099 Disease Relevance 0.40 Pain Relevance 0.04
Interferon beta (IFNß) decreases clinical relapses, reduces brain disease activity, and possibly slows down progression of disability.
Localization (decreases) of IFN in brain associated with brain disease and recurrence
19) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2271130 Disease Relevance 1.03 Pain Relevance 0.29
2b at 10 million units given subcutaneously three times per week was initiated based on the vascular nature of this tumor and IFN-?'
Localization (nature) of IFN associated with cancer
20) Confidence 0.45 Published 2006 Journal BMC Urol Section Body Doc Link PMC1564030 Disease Relevance 1.15 Pain Relevance 0

General Comments

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