INT55587

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Context Info
Confidence 0.49
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.10
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1)
cytoplasm (Gad1)
Anatomy Link Frequency
substantia nigra pars reticulata 2
globus pallidus 2
GABAergic neurons 2
Gad1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 9 100.00 Very High Very High Very High
substance P 4 100.00 Very High Very High Very High
Substantia nigra 4 99.68 Very High Very High Very High
Dopamine 30 99.58 Very High Very High Very High
antagonist 5 98.32 Very High Very High Very High
GABAergic 49 98.24 Very High Very High Very High
Enkephalin 6 96.48 Very High Very High Very High
dopamine receptor 6 87.80 High High
Glutamate 6 86.80 High High
Central grey 8 85.92 High High
Disease Link Frequency Relevance Heat
Parkinson's Disease 25 98.96 Very High Very High Very High
Bordatella Infection 2 93.52 High High
Disease 42 87.48 High High
Urological Neuroanatomy 12 85.92 High High
Dyskinesias 43 59.08 Quite High
Generalized Anxiety Disorder 42 5.00 Very Low Very Low Very Low
Primary Sclerosing Cholangitis 19 5.00 Very Low Very Low Very Low
Sleep Disorders 8 5.00 Very Low Very Low Very Low
Cognitive Disorder 8 5.00 Very Low Very Low Very Low
Hypokinesia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly the increase in GAD67 mRNA is abolished by levodopa treatment in MPTP-treated monkeys (Herrero et al., 1996).
Negative_regulation (abolished) of Positive_regulation (increase) of GAD67 mRNA associated with parkinson's disease
1) Confidence 0.49 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.76 Pain Relevance 0.03
Thalamic lesions prevented most of the dopamine denervation-induced changes (i.e. the increases in mRNA levels of enkephalin and GAD67 in the striatum, of GAD67 in the globus pallidus and entopeduncular nucleus, and of cytochrome oxidase subunit-I in the subthalamic nucleus), but did not affect the downregulation of striatal substance P and upregulation of GAD67 in the substantia nigra pars reticulata.
Negative_regulation (downregulation) of Positive_regulation (upregulation) of GAD67 in substantia nigra pars reticulata associated with dopamine, substantia nigra, enkephalin and substance p
2) Confidence 0.43 Published 2004 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 14748558 Disease Relevance 0.07 Pain Relevance 0.39
In these 15-day-old rats, however, sulpiride produced an increase in GAD67 but not preproenkephalin mRNA levels.
Neg (not) Negative_regulation (produced) of Positive_regulation (increase) of GAD67
3) Confidence 0.42 Published 1994 Journal Brain Res. Section Abstract Doc Link 8004444 Disease Relevance 0.09 Pain Relevance 0.35
The increases in GAD67, GAD65, and PPD mRNA levels induced by SKF-38393 were abolished by the administration of the D1 receptor antagonist SCH-23390.
Negative_regulation (abolished) of Positive_regulation (increases) of GAD67 associated with antagonist
4) Confidence 0.41 Published 1999 Journal Synapse Section Abstract Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.37
The dopamine denervation-induced increase in GAD67 mRNA levels in the globus pallidus was partially antagonized after HFS and totally reversed after ibotenate-induced STN lesion.
Negative_regulation (reversed) of Positive_regulation (increase) of GAD67 mRNA in globus pallidus associated with dopamine
5) Confidence 0.27 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15610165 Disease Relevance 0.09 Pain Relevance 0.35
To localize these GABAergic neurons, we combined immunohistochemical detection of Fos with non-radioactive in situ hybridization of GAD67 mRNA (GABA synthesis enzyme) in control rats, rats deprived of PS for 72 h and rats allowed to recover after such deprivation.
Negative_regulation (deprived) of Positive_regulation (hybridization) of GAD67 in GABAergic neurons associated with gaba and gabaergic
6) Confidence 0.17 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2629845 Disease Relevance 0.09 Pain Relevance 0.34

General Comments

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