INT55597

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Context Info
Confidence 0.55
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 59
Total Number 59
Disease Relevance 28.30
Pain Relevance 8.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gpx1) mitochondrion (Gpx1) oxidoreductase activity (Gpx1)
nucleus (Gpx1) lipid metabolic process (Gpx1) cytoplasm (Gpx1)
Anatomy Link Frequency
liver 6
erythrocyte 2
brain 2
epithelial cells 2
blood 2
Gpx1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 5 100.00 Very High Very High Very High
endometriosis 6 99.88 Very High Very High Very High
Enkephalin 14 99.76 Very High Very High Very High
Prostatitis 66 99.70 Very High Very High Very High
Paracetamol 130 99.40 Very High Very High Very High
Visceral pain 14 99.20 Very High Very High Very High
Chronic pancreatitis 6 99.12 Very High Very High Very High
Hippocampus 23 99.04 Very High Very High Very High
Glutamate 23 98.92 Very High Very High Very High
ischemia 71 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 732 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 32 100.00 Very High Very High Very High
Depression 5 100.00 Very High Very High Very High
Pancreatitis 14 99.92 Very High Very High Very High
Endometriosis (extended) 6 99.88 Very High Very High Very High
Prostatitis 66 99.70 Very High Very High Very High
Arthritis 60 99.68 Very High Very High Very High
Nephrotoxicity 60 99.50 Very High Very High Very High
Diabetes Mellitus 478 99.48 Very High Very High Very High
Cataract 27 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CAT and Gpx activities were lowered upon MENK exposure in males, but in females the activities were modulated by MENK.
Negative_regulation (lowered) of Gpx associated with enkephalin
1) Confidence 0.55 Published 2006 Journal Biogerontology Section Abstract Doc Link 16518720 Disease Relevance 0 Pain Relevance 0.91
Catalase and GPX activities, however, were decreased in the liver tissue of the GHR-KO mice.
Negative_regulation (decreased) of GPX in liver
2) Confidence 0.36 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.91 Pain Relevance 0
Unexpectedly, the expression of the enzymes that directly scavenge ROS decreased, including superoxide dismutases 1 and 2, glutathione peroxidase 1, and catalase.
Negative_regulation (decreased) of glutathione peroxidase 1
3) Confidence 0.30 Published 2007 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC1925139 Disease Relevance 0.08 Pain Relevance 0
It is worthy of mention that GH administration to dwarf mice, in vivo and in vitro, downregulates the oxidative defense capacity (GPX, catalase, SOD2 [MnSOD]) of these mice (Brown-Borg et al. 2002, Brown-Borg and Rakoczy 2003.
Negative_regulation (downregulates) of GPX
4) Confidence 0.26 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.26 Pain Relevance 0
There were general statistically significant losses in the activities of SOD, GPx, CAT, and delta-ALA-D and an increase in TBARS in the liver of paracetamol-treated group compared with the control group.
Negative_regulation (losses) of GPx in liver associated with paracetamol
5) Confidence 0.26 Published 2008 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 18054472 Disease Relevance 0.48 Pain Relevance 0.46
Glutamate-cysteine ligase catalytic subunit (GCLC), glutathione S-transferasemu, and glutathione peroxidase 1 were down-regulated in the liver of hepatocyte RXRalpha-deficient mice.
Negative_regulation (regulated) of glutathione peroxidase 1 in hepatocyte associated with glutamate
6) Confidence 0.25 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 14978233 Disease Relevance 0.14 Pain Relevance 0.23
The modulation of physiological antioxidant systems by TCM is thought to be a more probable mechanism for the preventative ability of SMS on stressor-mediated oxidative stress, since we previously reported that SMS prevented the loss of GPX activity in the brain after ischemia reperfusion in rats (18–23) in addition to its strong radical scavenging activity.
Negative_regulation (loss) of GPX in brain associated with stress and ischemia
7) Confidence 0.24 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1876613 Disease Relevance 0.61 Pain Relevance 0.05
Increased sensitivity to oxidative stress by opioid peptides was in both sexes mainly due to increased SOD activity followed by GPX decrease.
Negative_regulation (decrease) of GPX associated with stress and opioid
8) Confidence 0.21 Published 2005 Journal Physiol Res Section Abstract Doc Link 15717847 Disease Relevance 0.10 Pain Relevance 0.67
Judge et al (2003) postulated that the increase in PC may be a result of the reduction in SOD2 and GPx activity and/or that protein oxidation is transiently elevated in cardiac muscle [38].
Negative_regulation (reduction) of GPx in cardiac muscle
9) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.08 Pain Relevance 0
Schacter et al [23] and Gryglewksi et al [24] demonstrated that superoxide dismutase and catalase levels and activity are diminished in sickle RBCs at baseline; other investigators have found that GPx activity is reduced [25].
Negative_regulation (reduced) of GPx
10) Confidence 0.16 Published 2001 Journal Respir Res Section Body Doc Link PMC59517 Disease Relevance 0.27 Pain Relevance 0
Upon admission and every 8 h for 24 h, blood samples were drawn for the determination of plasma malondialdehyde (MDA) levels, Se-glutathione peroxidase (GPX) activity, erythrocyte reduced glutathione (GSH) concentrations, erythrocyte GPX and superoxide dismutase (SOD) activities.
Negative_regulation (reduced) of GPX in erythrocyte
11) Confidence 0.15 Published 1994 Journal Eur. Heart J. Section Abstract Doc Link 8005117 Disease Relevance 0.76 Pain Relevance 0.46
However, the pre-intake of carnosine or histidine significantly alleviated acetaminophen-induced oxidative stress by increasing GSH content, decreasing MDA, ROS, and GSSG formations, and retaining activity of GPX, catalase, and SOD in liver (P < 0.05).
Negative_regulation (decreasing) of GPX in liver associated with stress and paracetamol
12) Confidence 0.14 Published 2009 Journal J. Food Sci. Section Abstract Doc Link 19799668 Disease Relevance 0.56 Pain Relevance 0.68
The decrease in the catalase and GPx activities in TGF-beta1-treated cells resulted in an increase in intracellular peroxides as judged by flow cytometric analysis using a peroxide-sensitive dye, 2',7'-dichlorofluorescin diacetate.
Negative_regulation (decrease) of GPx
13) Confidence 0.11 Published 1997 Journal Free Radic. Biol. Med. Section Abstract Doc Link 9034240 Disease Relevance 0.15 Pain Relevance 0.07
In patients with endometriosis and adenomyosis, SOD and CAT were found to be abnormally expressed [11,12], while patients with endometriosis have lowered GPx activity [13].
Negative_regulation (lowered) of GPx associated with endometriosis and dismenorea
14) Confidence 0.10 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805669 Disease Relevance 1.32 Pain Relevance 0.20
They were glutathione peroxidase (GPX) as a down-regulated protein as well as peroxiredoxin 1 (PRX1) and peroxiredoxin 2 (PRX2) as up-regulated proteins, which are known to serve as antioxidative enzymes in cells.
Negative_regulation (down-regulated) of GPX
15) Confidence 0.09 Published 2005 Journal J Toxicol Sci Section Abstract Doc Link 16141655 Disease Relevance 0.57 Pain Relevance 0.22
Following CRD we observed (1) all rats expressed signs of visceral pain (overall rating was 1.83), (2) SOD and GPx levels were increased in the liver and blood, and decreased in the brain samples and (3) administration of the antioxidant Trolox, a water-soluble derivate of vitamin E, prior to CRD, prevented SOD and GPx changes in the liver, blood and brain, but did not affect pain scores.
Negative_regulation (decreased) of GPx in liver associated with visceral pain and pain score
16) Confidence 0.09 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417688 Disease Relevance 0.33 Pain Relevance 0.65
TGF-beta1 suppressed mRNA expression as well as reduced the activities of catalase and GPx.
Negative_regulation (reduced) of GPx
17) Confidence 0.08 Published 1997 Journal Free Radic. Biol. Med. Section Abstract Doc Link 9034240 Disease Relevance 0.15 Pain Relevance 0.08
A single dose of acetaminophen significantly elevated the levels of lipid peroxides (LPO) with decreased levels of free radical scavenger enzymes (SOD, CAT, GSH, GPx, GST) in liver homogenate.
Negative_regulation (decreased) of GPx in liver associated with paracetamol
18) Confidence 0.08 Published 2005 Journal Phytother Res Section Abstract Doc Link 15852486 Disease Relevance 0.50 Pain Relevance 0.51
GPx concentration was only diminished in the patients with chronic pancreatitis.
Negative_regulation (diminished) of GPx associated with chronic pancreatitis
19) Confidence 0.07 Published 2001 Journal Arch. Immunol. Ther. Exp. (Warsz.) Section Abstract Doc Link 11348018 Disease Relevance 1.46 Pain Relevance 0.34
This was paralleled by significant decline in the activities of glutathione-dependent antioxidant enzymes (GPx and GST) and antiperoxidative enzymes (SOD and CAT) in the heart tissue of Group III myocardial infarction induced rats.
Negative_regulation (decline) of GPx in heart associated with myocardial infarction
20) Confidence 0.07 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291504 Disease Relevance 0.10 Pain Relevance 0

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