INT55606

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 1994
Last Reported 2011
Negated 4
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 10.73
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Anatomy Link Frequency
blood 1
muscles 1
Ace (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX2 1 99.60 Very High Very High Very High
Calcium channel 1 98.32 Very High Very High Very High
fibrosis 61 98.24 Very High Very High Very High
bradykinin 8 98.10 Very High Very High Very High
chemokine 7 97.04 Very High Very High Very High
tolerance 5 96.12 Very High Very High Very High
beta blocker 7 92.00 High High
Chronic pancreatitis 64 91.36 High High
cytokine 23 91.08 High High
headache 2 89.68 High High
Disease Link Frequency Relevance Heat
Hypertension 164 100.00 Very High Very High Very High
Cough 6 99.98 Very High Very High Very High
Pancreatitis 256 99.76 Very High Very High Very High
Left Ventricular Hypertrophy 24 99.76 Very High Very High Very High
Pressure And Volume Under Development 13 99.20 Very High Very High Very High
Calcification 36 98.96 Very High Very High Very High
Diabetes Mellitus 164 98.56 Very High Very High Very High
Increased Venous Pressure Under Development 16 98.54 Very High Very High Very High
Fibrosis 61 98.24 Very High Very High Very High
Hypertrophy 8 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results indicate that ACE inhibition improves BF to ischemic muscles and, together with chronic physical activity, improves exercise tolerance.
ACE Neg (inhibition) Binding (inhibition) of in muscles associated with tolerance
1) Confidence 0.37 Published 1994 Journal J Clin Pharmacol Section Abstract Doc Link 8006202 Disease Relevance 0.16 Pain Relevance 0.25
Increased bradykinin leads to vasodilation via the release of endothelial nitric oxide but is also responsible for ACE inhibitor intolerance with cough.
ACE Binding (intolerance) of associated with cough, increased venous pressure under development and bradykinin
2) Confidence 0.35 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.85 Pain Relevance 0.26
This suggests that there is no interaction between the I/D variant in the ACE gene and the N34S mutation in the SPINK1 gene in either TCP or FCPD patients.
ACE Neg (no) Binding (interaction) of associated with diabetes mellitus and pancreatitis
3) Confidence 0.35 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1762011 Disease Relevance 0.83 Pain Relevance 0
We did not observe any association of the ACE I/D polymorphism with various phenotypic features including the age of onset and age of presentation, pancreatic calcification or surgeries (table 3).
ACE Neg (not) Binding (association) of associated with calcification
4) Confidence 0.35 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1762011 Disease Relevance 1.20 Pain Relevance 0.03
Post-hoc power analysis showed the study being adequately powered (84.6%) to accept the null hypothesis that the I/D polymorphism in ACE gene is not associated with TCP (?
ACE Binding (associated) of associated with pancreatitis
5) Confidence 0.35 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1762011 Disease Relevance 1.51 Pain Relevance 0.17
We investigated the association of I/D polymorphism in the ACE gene with TCP and the phenotype of diabetes in FCPD.
ACE Binding (association) of associated with diabetes mellitus and pancreatitis
6) Confidence 0.34 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1762011 Disease Relevance 1.96 Pain Relevance 0.19
Both ACE inhibitors were associated with an increase in the concentration of whole blood ANG I; however, tissue ANG I levels were significantly increased only following ACE inhibition with ramiprilat but not with enalaprilat.
ACE Binding (associated) of in blood
7) Confidence 0.32 Published 1996 Journal Am. J. Kidney Dis. Section Abstract Doc Link 8840953 Disease Relevance 0 Pain Relevance 0
In vivo endothelial interaction between ACE and COX inhibitors.
ACE Binding (interaction) of associated with cox2
8) Confidence 0.25 Published 2005 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Title Doc Link 15626595 Disease Relevance 0.14 Pain Relevance 0.22
Li et al.24 have suggested that the LVH in SHR was associated with ACE and ACE2 gene expression cardiac RAS, while aortic hypertrophy was associated with angiotensinogen and ACE2 gene expression of aortic RAS.
ACE Binding (associated) of associated with hypertrophy, left ventricular hypertrophy and hypertension
9) Confidence 0.18 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020347 Disease Relevance 0.80 Pain Relevance 0
Neither the dry cough associated with ACE inhibitors nor the edema associated with calcium channel blockers (CCBs) has been observed with telmisartan treatment (White 2002).
ACE Binding (associated) of associated with pressure and volume under development, calcium channel and cough
10) Confidence 0.17 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2293961 Disease Relevance 0.38 Pain Relevance 0.14
The contribution of ACE, NEP, or chymase enzyme activity to the hydrolysis of 125I-Ang-(1–12) was significantly higher in SHR (ACE?
ACE Binding (higher) of associated with hypertension
11) Confidence 0.16 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.62 Pain Relevance 0
This finding supports the evidence that some of the effects observed with quinapril are related to its high affinity for tissue ACE.
ACE Binding (affinity) of
12) Confidence 0.15 Published 2008 Journal J Transl Med Section Body Doc Link PMC2435101 Disease Relevance 0.52 Pain Relevance 0.28
Hernandez-Presa have shown that ACE inhibition prevents arterial NF-?
ACE Neg (inhibition) Binding (inhibition) of
13) Confidence 0.15 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.89 Pain Relevance 0.14
As RAAS has been implicated in oxidative damage, its interruption though ACE inhibition or angiotensin blockade may prevent the development of CRS.
ACE Binding (interruption) of associated with syndrome
14) Confidence 0.09 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC2989717 Disease Relevance 0.88 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox