INT55611

Context Info Confidence 0.46 First Reported 1994 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 6 Total Number 6 Disease Relevance 0.59 Pain Relevance 3.84

Anatomy Link Frequency blood 1 CSF 1 brain 1 urine 1 H2-M3 (Mus musculus)

Pain Link Frequency Relevance Heat Morphine 56 100.00 Pain 7 75.00 intrathecal 1 71.20 Analgesic 1 54.88 MU agonist 2 5.00

Disease Link Frequency Relevance Heat Renal Failure 5 99.84 Pain 4 75.00 Cancer 1 66.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Isolation reduced the plasma levels of morphine and of M3G, but did not alter the brain concentration of morphine.

Negative_regulation (reduced) of M3G in brain

1) Confidence 0.46 Published 1999 Journal Psychopharmacology (Berl.) Section Body Doc Link 10435385 Disease Relevance 0 Pain Relevance 0

M3G gradually increased after the morphine injection, peaked about 2 days later, then gradually decreased.

Negative_regulation (decreased) of M3G associated with morphine

2) Confidence 0.03 Published 2008 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 18307503 Disease Relevance 0 Pain Relevance 1.05

The median molar ratios for CSF/serum distribution of morphine, M6G and M3G were 1.23, 0.12 and 0.14, respectively.

Negative_regulation (distribution) of M3G in CSF associated with morphine

3) Confidence 0.00 Published 1994 Journal Pain Section Abstract Doc Link 8008404 Disease Relevance 0.28 Pain Relevance 1.77

In contrast, the two groups of IHU (street heroin taking or morphine-treated subjects) showed a reduction of blood and urine M3G concentrations in favor of M6G.

Negative_regulation (reduction) of M3G in urine

4) Confidence 0.00 Published 2003 Journal Psychopharmacology (Berl.) Section Body Doc Link 12774191 Disease Relevance 0 Pain Relevance 0

The renal extraction of M3G and M6G and urinary recovery of the dose as summed morphine, M3G and M6G were reduced by renal failure.

Negative_regulation (reduced) of M3G associated with renal failure and morphine

5) Confidence 0.00 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262341 Disease Relevance 0.31 Pain Relevance 1.03

In contrast, the two groups of IHU (street heroin taking or morphine-treated subjects) showed a reduction of blood and urine M3G concentrations in favor of M6G.

Negative_regulation (reduction) of M3G in blood

6) Confidence 0.00 Published 2003 Journal Psychopharmacology (Berl.) Section Body Doc Link 12774191 Disease Relevance 0 Pain Relevance 0

General Comments

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