INT55611

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Context Info
Confidence 0.46
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.59
Pain Relevance 3.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
CSF 1
brain 1
urine 1
H2-M3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 56 100.00 Very High Very High Very High
Pain 7 75.00 Quite High
intrathecal 1 71.20 Quite High
Analgesic 1 54.88 Quite High
MU agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Failure 5 99.84 Very High Very High Very High
Pain 4 75.00 Quite High
Cancer 1 66.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Isolation reduced the plasma levels of morphine and of M3G, but did not alter the brain concentration of morphine.
Negative_regulation (reduced) of M3G in brain
1) Confidence 0.46 Published 1999 Journal Psychopharmacology (Berl.) Section Body Doc Link 10435385 Disease Relevance 0 Pain Relevance 0
M3G gradually increased after the morphine injection, peaked about 2 days later, then gradually decreased.
Negative_regulation (decreased) of M3G associated with morphine
2) Confidence 0.03 Published 2008 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 18307503 Disease Relevance 0 Pain Relevance 1.05
The median molar ratios for CSF/serum distribution of morphine, M6G and M3G were 1.23, 0.12 and 0.14, respectively.
Negative_regulation (distribution) of M3G in CSF associated with morphine
3) Confidence 0.00 Published 1994 Journal Pain Section Abstract Doc Link 8008404 Disease Relevance 0.28 Pain Relevance 1.77
In contrast, the two groups of IHU (street heroin taking or morphine-treated subjects) showed a reduction of blood and urine M3G concentrations in favor of M6G.
Negative_regulation (reduction) of M3G in urine
4) Confidence 0.00 Published 2003 Journal Psychopharmacology (Berl.) Section Body Doc Link 12774191 Disease Relevance 0 Pain Relevance 0
The renal extraction of M3G and M6G and urinary recovery of the dose as summed morphine, M3G and M6G were reduced by renal failure.
Negative_regulation (reduced) of M3G associated with renal failure and morphine
5) Confidence 0.00 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262341 Disease Relevance 0.31 Pain Relevance 1.03
In contrast, the two groups of IHU (street heroin taking or morphine-treated subjects) showed a reduction of blood and urine M3G concentrations in favor of M6G.
Negative_regulation (reduction) of M3G in blood
6) Confidence 0.00 Published 2003 Journal Psychopharmacology (Berl.) Section Body Doc Link 12774191 Disease Relevance 0 Pain Relevance 0

General Comments

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