INT55658

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Context Info
Confidence 0.47
First Reported 1993
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.14
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HTR4) plasma membrane (HTR4) cytoplasm (HTR4)
signal transducer activity (HTR4)
Anatomy Link Frequency
visceral 1
tails 1
HTR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 51 100.00 Very High Very High Very High
Morphine 7 99.44 Very High Very High Very High
spastic colon 56 99.20 Very High Very High Very High
Neurotransmitter 3 98.12 Very High Very High Very High
nud 13 96.12 Very High Very High Very High
agonist 159 96.04 Very High Very High Very High
antagonist 64 86.80 High High
abdominal pain 12 37.16 Quite Low
Migraine 28 5.00 Very Low Very Low Very Low
antidepressant 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 21 99.36 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

44 99.20 Very High Very High Very High
Functional Bowel Disorder 29 99.00 Very High Very High Very High
Dyspepsia 13 96.12 Very High Very High Very High
Constipation 113 86.36 High High
Cancer 1 85.24 High High
Diarrhoea 10 83.76 Quite High
Gastric Motility Disorder 5 82.32 Quite High
Stress Incontinence 7 74.40 Quite High
Ataxia 4 73.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of drugs interacting with serotonergic 5HT3 and 5HT4 receptors on morphine place conditioning.
5HT4 Binding (interacting) of associated with morphine
1) Confidence 0.47 Published 1993 Journal Pol J Pharmacol Section Title Doc Link 8012474 Disease Relevance 0 Pain Relevance 0.80
In this review, I describe the background to 5-HT in gastrointestinal physiology and disease, and the actions of drugs that interact with 5-HT3 and 5-HT4 receptors.
5-HT4 Binding (interact) of associated with disease
2) Confidence 0.47 Published 2008 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 19086255 Disease Relevance 0.60 Pain Relevance 0.16
Specifically, it binds with high affinity to human 5-HT4 receptors, thereby stimulating the release of neurotransmitters and the peristaltic reflex in vitro.
5-HT4 Binding (binds) of associated with neurotransmitter
3) Confidence 0.36 Published 1999 Journal Drugs Section Abstract Doc Link 10493276 Disease Relevance 0.38 Pain Relevance 0.53
Binding of serotonin to 5-HT4 receptors stimulates peristalsis, modulates fluid content of the colonic content, and decreases visceral hypersensitivity (Crowell 2001; De Ponti 2004).
5-HT4 Binding (Binding) of in visceral associated with nud and serotonin
4) Confidence 0.35 Published 2008 Journal Core Evidence Section Body Doc Link PMC2899805 Disease Relevance 0.92 Pain Relevance 0.39
Of these proteins, 10 interact specifically with the mouse 5–HT4(a) receptor splice variant.
HT4 Binding (interact) of
5) Confidence 0.05 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0 Pain Relevance 0.04
So far, there have been no reports on GIP interactions with any 5–HT4 or 5–HT7 receptor splice variants in human tissue.
HT4 Neg (no) Binding (interactions) of
6) Confidence 0.04 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0 Pain Relevance 0.07
However, a recent study identified 13 GIPs (mainly PDZ domain proteins) that interact with either the mouse 5–HT4(a) or 5–HT4(e) receptors [42].
HT4 Binding (interact) of
7) Confidence 0.04 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0 Pain Relevance 0.04
It is noteworthy that PSD-95 interacts with 5–HT2A and 5–HT2C but notHT4(a) receptors indicating that the different tails containing PDZ ligands interact with specific sets of proteins [12,42].
HT4 Neg (not) Binding (interacts) of in tails
8) Confidence 0.03 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0 Pain Relevance 0.16

General Comments

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