INT55669

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Context Info
Confidence 0.13
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 11.28
Pain Relevance 5.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ik)
Anatomy Link Frequency
adipocytes 8
T cells 6
lung 4
pyramidal neurons 2
astrocytes 2
Ik (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 396 100.00 Very High Very High Very High
Inflammation 220 100.00 Very High Very High Very High
Morphine 78 99.68 Very High Very High Very High
Inflammatory mediators 21 98.16 Very High Very High Very High
Arthritis 40 97.84 Very High Very High Very High
Pyramidal cell 20 97.72 Very High Very High Very High
Inflammatory response 43 93.68 High High
ischemia 18 90.48 High High
agonist 3 90.40 High High
metalloproteinase 15 89.76 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 292 100.00 Very High Very High Very High
Hyperplasia 30 99.96 Very High Very High Very High
Obesity 488 99.84 Very High Very High Very High
Myocardial Infarction 81 99.68 Very High Very High Very High
Death 25 99.28 Very High Very High Very High
Rupture 3 98.16 Very High Very High Very High
Targeted Disruption 73 98.04 Very High Very High Very High
Arthritis 52 97.84 Very High Very High Very High
Infection 72 97.76 Very High Very High Very High
Helminth Infection 50 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of SK1 and SK2 subunits, as well as the application of 1-EBIO, lead to a selective enhancement of the apamin-sensitive IAHP [93, 94], while this current is strongly reduced in layer 5 pyramidal neurons from transgenic mice expressing a truncated form of the SK3 subunit that acts in a dominant negative fashion and suppresses the expression of all SK and IK channels [94].
Negative_regulation (suppresses) of Gene_expression (expression) of IK in pyramidal neurons associated with targeted disruption and pyramidal cell
1) Confidence 0.13 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.10 Pain Relevance 0.26
These results clearly differentiate CSAID from the other compounds tested and suggest that CSAID are relatively weak inhibitors of PGHS 1 while being potent inhibitors of inflammatory cytokine production.
Negative_regulation (inhibitors) of Gene_expression (production) of cytokine associated with inflammation and cytokine
2) Confidence 0.02 Published 1993 Journal Drugs Exp Clin Res Section Abstract Doc Link 8013267 Disease Relevance 0.52 Pain Relevance 0.54
Our results show that the newly discovered Bv8/prokineticin system plays a role in modulating T cell function by reducing Th2 cytokine levels and IL-10 production, thus indirectly switching the cells towards a Th1 and pro-inflammatory state.
Negative_regulation (reducing) of Gene_expression (production) of cytokine in T cell associated with inflammation and cytokine
3) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.28 Pain Relevance 0.27
These findings were confirmed by Kawano et al. [52], who found reduced ventricular rupture, improved systolic and diastolic dimensions and function, reduced collagen deposition, and reduced cytokine expression postinfarction in p50 KO mice.
Negative_regulation (reduced) of Gene_expression (expression) of cytokine associated with rupture and cytokine
4) Confidence 0.01 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.49 Pain Relevance 0.21
Tregs from HF patients had a reduced functional capacity to suppress cytokine production from CD4 + CD25- T cells [25, 26].
Negative_regulation (suppress) of Gene_expression (production) of cytokine in T cells associated with myocardial infarction and cytokine
5) Confidence 0.01 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.87 Pain Relevance 0.24
Tregs from HF patients had a reduced functional capacity to suppress cytokine production from CD4 + CD25- T cells [25, 26].
Negative_regulation (reduced) of Gene_expression (production) of cytokine in T cells associated with myocardial infarction and cytokine
6) Confidence 0.01 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.87 Pain Relevance 0.24
ultimately results in a delayed mucosal response and depressed MLN cytokine production.
Negative_regulation (depressed) of Gene_expression (production) of cytokine associated with cytokine
7) Confidence 0.01 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.38 Pain Relevance 0.11
The delayed expulsion was related to a delayed intestinal goblet cell hyperplasia, reduced T helper 2 cytokine production in the mesenteric lymph node, and reduced M3 muscarinic receptor expression during infection.
Negative_regulation (reduced) of Gene_expression (production) of cytokine in goblet cell associated with infection, hyperplasia and cytokine
8) Confidence 0.01 Published 2007 Journal PLoS Pathogens Section Abstract Doc Link PMC1769405 Disease Relevance 0.99 Pain Relevance 0.14
This treatment also down-regulated cytokine expression and reduced cell death in the lung.


Negative_regulation (down) of Gene_expression (expression) of cytokine in lung associated with death and cytokine
9) Confidence 0.01 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2211395 Disease Relevance 1.00 Pain Relevance 0.17
This treatment also down-regulated cytokine expression and reduced cell death in the lung.


Negative_regulation (regulated) of Gene_expression (expression) of cytokine in lung associated with death and cytokine
10) Confidence 0.01 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2211395 Disease Relevance 1.00 Pain Relevance 0.17
B; causing p65 (RelA) accumulation in the nucleus, and significantly attenuated cytokine production in Tat±morphine exposed astrocytes.
Negative_regulation (attenuated) of Gene_expression (production) of cytokine in astrocytes associated with morphine and cytokine
11) Confidence 0.01 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2605563 Disease Relevance 0.35 Pain Relevance 1.00
The beneficial effects of Perna were associated with reductions in anti-collagen antibody levels, pro-inflammatory cytokine production, superoxide release, and amelioration of established CIA.
Negative_regulation (reductions) of Gene_expression (production) of cytokine associated with inflammation, arthritis and cytokine
12) Confidence 0.00 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1899520 Disease Relevance 0.53 Pain Relevance 0.26
B activation in adipocytes and in doing so inhibit cytokine expression in these cells.
Negative_regulation (inhibit) of Gene_expression (expression) of cytokine in adipocytes associated with obesity and cytokine
13) Confidence 0.00 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2441623 Disease Relevance 0.74 Pain Relevance 0.42
Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes

Background

Negative_regulation (inhibit) of Gene_expression (expression) of cytokine in adipocytes associated with obesity and cytokine
14) Confidence 0.00 Published 2008 Journal Nutr Metab (Lond) Section Title Doc Link PMC2441623 Disease Relevance 1.25 Pain Relevance 0.40
B signaling in adipocytes and as a result significantly reduce cytokine expression.
Negative_regulation (reduce) of Gene_expression (expression) of cytokine in adipocytes associated with obesity and cytokine
15) Confidence 0.00 Published 2008 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2441623 Disease Relevance 0.65 Pain Relevance 0.15
B activation in adipocytes and in doing so reduce cytokine expression.


Negative_regulation (reduce) of Gene_expression (expression) of cytokine in adipocytes associated with obesity and cytokine
16) Confidence 0.00 Published 2008 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2441623 Disease Relevance 1.26 Pain Relevance 0.42

General Comments

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