INT55670

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 2010
Negated 4
Speculated 5
Reported most in Abstract
Documents 83
Total Number 88
Disease Relevance 57.16
Pain Relevance 46.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
macrophages 25
neutrophil 8
RAW 264 7
sympathetic 4
liver 4
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 166 100.00 Very High Very High Very High
Paracetamol 85 100.00 Very High Very High Very High
qutenza 81 100.00 Very High Very High Very High
Morphine 75 100.00 Very High Very High Very High
Nucleus accumbens 1 100.00 Very High Very High Very High
Dopamine 1 100.00 Very High Very High Very High
Hyperalgesia 12 99.98 Very High Very High Very High
Inflammatory response 27 99.92 Very High Very High Very High
Etanercept 2 99.92 Very High Very High Very High
Inflammation 301 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 109 100.00 Very High Very High Very High
Necrosis 82 100.00 Very High Very High Very High
Adhesions 17 100.00 Very High Very High Very High
Obesity 16 100.00 Very High Very High Very High
Alzheimer's Dementia 13 100.00 Very High Very High Very High
Hyperalgesia 17 99.98 Very High Very High Very High
Sepsis 23 99.92 Very High Very High Very High
Bacterial Infection 3 99.92 Very High Very High Very High
Wallerian Degeneration 15 99.88 Very High Very High Very High
INFLAMMATION 339 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, TNF-alpha production was significantly reduced.
Negative_regulation (reduced) of Gene_expression (production) of TNF-alpha
1) Confidence 0.59 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10337911 Disease Relevance 0.52 Pain Relevance 0.19
Subcutaneous injection of morphine decreased LPS-induced TNF-alpha production throughout the response, an effect that was dose-dependent and reversible by naloxone.
Negative_regulation (decreased) of Gene_expression (production) of TNF-alpha associated with narcan and morphine
2) Confidence 0.59 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058753 Disease Relevance 0.39 Pain Relevance 0.72
While infliximab induced a downregulation of the production of the T-helper 1-cytokines IFNgamma and TNFalpha, etanercept treatment triggered rather an upregulation of these cytokines secreted by T cells after in vitro stimulation.
Negative_regulation (downregulation) of Gene_expression (production) of TNFalpha in T cells associated with infliximab, etanercept and cytokine
3) Confidence 0.58 Published 2002 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 12463444 Disease Relevance 0.25 Pain Relevance 0.50
Thalidomide has been shown to selectively inhibit TNF-alpha production.
Negative_regulation (inhibit) of Gene_expression (production) of TNF-alpha
4) Confidence 0.57 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10720640 Disease Relevance 0.71 Pain Relevance 0.34
The demonstration that thalidomide is able to inhibit inflammatory hyperalgesia in rats and the writhing nociceptive response in mice suggests that these analgesic effects seem to be a consequence of the inhibition of TNF-alpha production, and indicates the need for investigations on the possibility of the use of thalidomide for the treatment of pain refractory to classical non-narcotic analgesics.
Negative_regulation (inhibition) of Gene_expression (production) of TNF-alpha associated with nociception, pain refractory, hyperalgesia, inflammation and analgesic
5) Confidence 0.57 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10720640 Disease Relevance 0.76 Pain Relevance 0.78
The CSAID (exemplified by SK&F 86002, SK&F 105809 and SK&F 104351), strongly inhibited TNF alpha production in this model system (ED50s of 32, 48, and 34 mg/kg p.o., respectively).
Negative_regulation (inhibited) of Gene_expression (production) of TNF alpha
6) Confidence 0.57 Published 1993 Journal Drugs Exp Clin Res Section Abstract Doc Link 8013267 Disease Relevance 0.60 Pain Relevance 0.64
Capsaicin inhibits the production of tumor necrosis factor alpha by LPS-stimulated murine macrophages, RAW 264.7: a PPARgamma ligand-like action as a novel mechanism.
Negative_regulation (inhibits) of in RAW 264 Gene_expression (production) of tumor necrosis factor in macrophages associated with necrosis, qutenza and cancer
7) Confidence 0.57 Published 2004 Journal FEBS Lett. Section Title Doc Link 15304360 Disease Relevance 0.54 Pain Relevance 1.17
Ultralow concentrations (10(-16)-10(-12) M) of dynorphin (dyn) A-(1-8) significantly inhibited the LPS-induced production of NO or TNF-alpha.
Negative_regulation (inhibited) of Gene_expression (production) of TNF-alpha associated with dynorphin
8) Confidence 0.56 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8996182 Disease Relevance 0.16 Pain Relevance 0.56
The EA-treated mutant hSOD1 transgenic mice showed decreases in microglial cell activity and TNF-alpha expression in the spinal cord and brain stem.
Negative_regulation (decreases) of Gene_expression (expression) of TNF-alpha in brain stem associated with targeted disruption, electroacupuncture and spinal cord
9) Confidence 0.56 Published 2010 Journal J. Neuroimmunol. Section Abstract Doc Link 20460191 Disease Relevance 1.05 Pain Relevance 0.76
These data suggest that IL-10 inhibits ET-induced hyperalgesia by downregulation of TNFalpha, IL-1beta and NGF production.
Negative_regulation (downregulation) of Gene_expression (production) of TNFalpha associated with hyperalgesia
10) Confidence 0.56 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9663559 Disease Relevance 0.50 Pain Relevance 0.29
Among the serum proinflammatory cytokines, the production of TNF-alpha in the BV group was suppressed compared to the control group (59 +/- 4.5 versus 99.5 +/- 6.5, p < 0.05), but IL-1beta was not suppressed.
Negative_regulation (suppressed) of Gene_expression (production) of TNF-alpha associated with cytokine
11) Confidence 0.53 Published 2004 Journal Am. J. Chin. Med. Section Abstract Doc Link 15344419 Disease Relevance 1.11 Pain Relevance 0.71
In addition, the hypothesis that PEA might act through the modulation of local mast cells degranulation is sustained by our findings showing that PEA significantly reduced the production of many mediators such as TNFalpha and neurotrophic factors, like NGF.
Negative_regulation (reduced) of Gene_expression (production) of TNFalpha in mast cells
12) Confidence 0.52 Published 2008 Journal Pain Section Abstract Doc Link 18602217 Disease Relevance 0.64 Pain Relevance 0.88
The opioid antagonist naltrexone blocks acute endotoxic shock by inhibiting tumor necrosis factor-alpha production.
Negative_regulation (inhibiting) of Gene_expression (production) of tumor necrosis factor-alpha associated with necrosis, cancer, antagonist, bacterial infection and opioid
13) Confidence 0.51 Published 2004 Journal Brain Behav. Immun. Section Title Doc Link 15265541 Disease Relevance 1.11 Pain Relevance 0.65
Naltrexone significantly inhibited the production of TNF-alpha induced by LPS, but not SEB in vivo.
Negative_regulation (inhibited) of Gene_expression (production) of TNF-alpha
14) Confidence 0.51 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 15265541 Disease Relevance 0.91 Pain Relevance 0.66
Treatment with antibiotics inhibited microbial translocation, inhibited contraction of the colon, reduced lipopolysaccharides (LPS)-elicited production of TNF-alpha and IL-6, and finally prolonged survival.
Negative_regulation (reduced) of Gene_expression (production) of TNF-alpha in colon
15) Confidence 0.51 Published 2007 Journal Microbiol. Immunol. Section Abstract Doc Link 17895602 Disease Relevance 0.42 Pain Relevance 0.08
Deltorphin-Dvariant, but not DADLE or DPDPE, dose-dependently reduced both TNFalpha and MIP-2 production.
Negative_regulation (reduced) of Gene_expression (production) of TNFalpha
16) Confidence 0.50 Published 2005 Journal J. Surg. Res. Section Body Doc Link 15921696 Disease Relevance 0 Pain Relevance 0
TNF-alpha production from PM phi was inhibited by only high concentration (1 mmol L-1) of morphine which was not blocked by naloxone.
Negative_regulation (inhibited) of Gene_expression (production) of TNF-alpha
17) Confidence 0.50 Published 1995 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 8701766 Disease Relevance 0 Pain Relevance 0
The hydrogel degraded in media over 5 days, releasing dexamethasone slowly over that time, reducing TNF-alpha and IL-6 production from lipopolysaccharide-stimulated primary mouse macrophages in vitro.
Negative_regulation (reducing) of Gene_expression (production) of TNF-alpha in macrophages associated with dexamethasone
18) Confidence 0.50 Published 2007 Journal Biomaterials Section Abstract Doc Link 17204321 Disease Relevance 0.50 Pain Relevance 0.34
Capsaicin significantly inhibited the production of TNFalpha by macrophages in a dose-dependent manner.
Negative_regulation (inhibited) of Gene_expression (production) of TNFalpha in macrophages associated with qutenza
19) Confidence 0.49 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 15304360 Disease Relevance 0.51 Pain Relevance 1.23
Simultaneous exposure of the cells to capsaicin and PPARgamma agonist troglitazone or RXR agonist LG100268 resulted in stronger inhibition of TNFalpha production compared to the cells treated with either capsaicin, troglitazone, or LG100268 alone.
Negative_regulation (inhibition) of Gene_expression (production) of TNFalpha associated with qutenza and agonist
20) Confidence 0.49 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 15304360 Disease Relevance 0.48 Pain Relevance 1.35

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