INT55671

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Context Info
Confidence 0.27
First Reported 1993
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 151
Total Number 154
Disease Relevance 80.10
Pain Relevance 48.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ik)
Anatomy Link Frequency
adipocytes 17
T cells 14
macrophages 8
astrocytes 5
goblet cell 3
Ik (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4629 100.00 Very High Very High Very High
Inflammation 2864 100.00 Very High Very High Very High
chemokine 359 99.80 Very High Very High Very High
Morphine 879 99.68 Very High Very High Very High
Potency 62 99.48 Very High Very High Very High
Inflammatory response 386 99.44 Very High Very High Very High
Inflammatory mediators 192 99.28 Very High Very High Very High
Neurotransmitter 41 98.98 Very High Very High Very High
rheumatoid arthritis 778 98.72 Very High Very High Very High
Bile 1 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3406 100.00 Very High Very High Very High
Obesity 2938 99.98 Very High Very High Very High
Cancer 237 99.96 Very High Very High Very High
Apoptosis 129 99.88 Very High Very High Very High
Hypersensitivity 319 99.80 Very High Very High Very High
Necrosis 143 99.72 Very High Very High Very High
Targeted Disruption 308 99.64 Very High Very High Very High
Asthma 569 99.60 Very High Very High Very High
Hyperplasia 179 99.58 Very High Very High Very High
Disease 1130 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another prominent site of expression of SK and IK channels in the brain is the cerebral vasculature, in which the function of these channels has been investigated.
Gene_expression (expression) of IK in vasculature
1) Confidence 0.27 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.17 Pain Relevance 0.05
Thus, in peripheral vessels, it has been shown that EDHF-mediated responses are abolished by the combined inhibition of both SK and IK channels [178] that are expressed exclusively in endothelial cells [181, 183, 184].
Gene_expression (expressed) of IK in endothelial cells
2) Confidence 0.24 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.15 Pain Relevance 0
A recent study found that while SK2 and SK3 channels are present only in the endothelium, IK channels are expressed both in endothelial and smooth muscle cells of middle cerebral arteries [187].
Gene_expression (expressed) of IK in smooth muscle cells
3) Confidence 0.24 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.17 Pain Relevance 0
Cultured microglial cells from rat and mouse brain have been shown to express both SK (SK2, SK3) and IK channels [173, 174].
Gene_expression (express) of IK in microglial cells
4) Confidence 0.24 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.10 Pain Relevance 0.07
Although the relative contribution of each of these mechanisms and their possible interplay are still somewhat controversial and might depend on the type of blood vessel and stimulation, a considerable consensus has been reached that the initial step of EDHF-dependent relaxation is the activation of SK (in particular SK3) and IK channels in the endothelium (reviewed in [177–179]), as supported also by findings in genetically modified mice overexpressing or lacking SK3 [181] or lacking IK channels [182].
Gene_expression (overexpressing) of IK in blood vessel
5) Confidence 0.21 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.17 Pain Relevance 0
7400-fold (IK channels) and ?
Gene_expression (channels) of IK
6) Confidence 0.21 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.14
The biophysical characterization in heterologous expression systems showed the voltage independence of SK and IK channels and a half maximal activation by ?
Gene_expression (channels) of IK
7) Confidence 0.21 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.03
The most specific and potent positive modulator of IK and SK channels characterized so far is NS309, displaying a potency ?
Gene_expression (channels) of IK associated with potency
8) Confidence 0.21 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.14
Overexpression of SK1 and SK2 subunits, as well as the application of 1-EBIO, lead to a selective enhancement of the apamin-sensitive IAHP [93, 94], while this current is strongly reduced in layer 5 pyramidal neurons from transgenic mice expressing a truncated form of the SK3 subunit that acts in a dominant negative fashion and suppresses the expression of all SK and IK channels [94].
Gene_expression (expression) of IK in pyramidal neurons associated with targeted disruption and pyramidal cell
9) Confidence 0.18 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.10 Pain Relevance 0.26
Detection of RNA by Northern analysis, in situ hybridization or RT-PCR analysis and protein by immunohistochemistry have revealed that SK1, SK2, and SK3 channels are expressed in the central (CNS) and peripheral (PNS) nervous system [18, 31–38], while IK seems not to be present in central neurons, but is expressed in blood and epithelial cells [19–21, 39], and in peripheral sensory, sympathetic and enteric neurons [37, 38, 40–43].
Gene_expression (expressed) of IK in nervous system
10) Confidence 0.18 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.04
It is, however, clear that Ca2+-dependent K+ channels of the SK and IK type are both expressed in cerebral blood vessels and play a significant role in the regulation of local blood flow [185–188].


Gene_expression (expressed) of IK in blood
11) Confidence 0.18 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.21 Pain Relevance 0.03
To this end we introduced the Discoma coral-derived red fluorescent protein (DsRed2) into the NCTC 2472 fibrosarcoma line using the Sleeping Beauty transposon methodology, thus providing a unique opportunity to visualize tumor-nerve-vessel associations in context with behavioral assessment of tumor-associated hyperalgesia.
Gene_expression (introduced) of red fluorescent protein in nerve associated with fibrosarcoma, hyperalgesia and cancer
12) Confidence 0.07 Published 2005 Journal Pain Section Abstract Doc Link 15836973 Disease Relevance 1.63 Pain Relevance 0.52
Two hours thereafter, peritoneal (pMphi) and splenic macrophages (sMphi) were harvested and assessed not only for their ability to release IL-1 and IL-6, but also for cytokine gene expression using semiquantitative reverse transcription and PCR.
Gene_expression (expression) of cytokine in splenic macrophages associated with cytokine
13) Confidence 0.06 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8955229 Disease Relevance 0.59 Pain Relevance 0.32
Adherent cells were stimulated with lipopolysaccharide (LPS: 10 microg/mL) plus interferon-gamma (IFN-gamma: 100 units/mL) to induce cytokine production.
Gene_expression (production) of cytokine associated with cytokine
14) Confidence 0.05 Published 2000 Journal J. Leukoc. Biol. Section Abstract Doc Link 11073113 Disease Relevance 0.22 Pain Relevance 0.74
After 24 h RNA was extracted for analysis of cytokine mRNA levels by reverse transcriptase-polymerase chain reaction, or supernatants were collected after 48 h for determination of cytokine production by enzyme-linked immunosorbent assay (ELISA).
Gene_expression (production) of cytokine associated with cytokine
15) Confidence 0.05 Published 2000 Journal J. Leukoc. Biol. Section Abstract Doc Link 11073113 Disease Relevance 0.26 Pain Relevance 0.93
For intracellular cytokine staining, splenocytes were incubated for 5 hours at 37°C in RP10 (RPMI with 10% FBS, 10 mM HEPES, 4 mM L-Glutamine, 100 U/ml penicilin, 100 µg/mL streptomycin, 50 µM ?
Gene_expression (staining) of cytokine associated with cytokine
16) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.07 Pain Relevance 0.08
A recent paper elegantly addressed this question by using the drd1a promoter to drive the expression of tdTomato, a red fluorescent protein, in BAC transgenic mice [21].
Gene_expression (expression) of red fluorescent protein associated with targeted disruption
17) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.22 Pain Relevance 0.12
IDelayed is a composite current, consisting of residual IA, non-inactivating IK,v, and IK(Ca) (Alkon et al., 1984; Farley, 1988; Farley and Wu, 1989; Jin et al., 2009).
Gene_expression (al.) of IK
18) Confidence 0.04 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2928666 Disease Relevance 0 Pain Relevance 0
The stimulation of tumour necrosis factor alpha (TNF alpha) production by lipopolysaccharide (LPS) has been widely used, both in vitro and in vivo, to examine the biochemistry and pharmacology of inflammatory cytokine production.
Spec (examine) Gene_expression (production) of cytokine associated with necrosis, inflammation, cancer and cytokine
19) Confidence 0.03 Published 1993 Journal Drugs Exp Clin Res Section Abstract Doc Link 8013267 Disease Relevance 0.76 Pain Relevance 0.47
These results clearly differentiate CSAID from the other compounds tested and suggest that CSAID are relatively weak inhibitors of PGHS 1 while being potent inhibitors of inflammatory cytokine production.
Gene_expression (production) of cytokine associated with inflammation and cytokine
20) Confidence 0.03 Published 1993 Journal Drugs Exp Clin Res Section Abstract Doc Link 8013267 Disease Relevance 0.52 Pain Relevance 0.53

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