INT55682

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Context Info
Confidence 0.46
First Reported 1994
Last Reported 2001
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.17
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (IL1B, TIMP1) extracellular region (IL1B, TIMP1) cytosol (IL1B)
signal transduction (IL1B) extracellular space (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
fibroblasts 1
IL1B (Homo sapiens)
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 97.10 Very High Very High Very High
Inflammatory mediators 1 77.92 Quite High
metalloproteinase 2 75.00 Quite High
Snapping jaw 1 50.00 Quite Low
COX2 1 10.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 3 96.98 Very High Very High Very High
Temporomandibular Joint Syndrome 1 50.00 Quite Low
Sprains And Strains 1 50.00 Quite Low
Cancer 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, commonly used non-steroidal anti-inflammatory drugs (indomethacin, acetyl salicylic acid and ibuprofen), at doses which block prostaglandin synthesis in cultured fibroblasts, failed to counteract IL-1-induced collagenase and stromelysin gene expression, nor did they affect TIMP expression.
IL-1 Positive_regulation (induced) of collagenase in fibroblasts associated with inflammation and cinod
1) Confidence 0.46 Published 1994 Journal J. Cell. Biochem. Section Abstract Doc Link 8014195 Disease Relevance 0.17 Pain Relevance 0.28
Additionally, IL-1beta induced significant levels of collagenase (matrix metalloproteinase 1 [MMP-1]) within 4 hours, and this was sustained over a period of 48 hours.
IL-1beta Positive_regulation (induced) of collagenase
2) Confidence 0.04 Published 2001 Journal Arthritis Rheum. Section Body Doc Link 11263775 Disease Relevance 0 Pain Relevance 0

General Comments

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