INT55687

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Context Info
Confidence 0.74
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 47
Total Number 47
Disease Relevance 30.24
Pain Relevance 12.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TIMP1) extracellular region (TIMP1)
Anatomy Link Frequency
Plasma 3
Macrophages 2
leukocytes 2
T cell 2
capsule 1
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 936 100.00 Very High Very High Very High
cytokine 405 100.00 Very High Very High Very High
Osteoarthritis 131 99.48 Very High Very High Very High
Arthritis 349 98.72 Very High Very High Very High
Inflammation 511 98.60 Very High Very High Very High
rheumatoid arthritis 391 98.56 Very High Very High Very High
Infliximab 107 97.80 Very High Very High Very High
Calcitonin gene-related peptide 10 97.52 Very High Very High Very High
adenocard 21 96.64 Very High Very High Very High
pulpitis 4 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 609 100.00 Very High Very High Very High
Necrosis 23 100.00 Very High Very High Very High
Autoimmune Disease 16 99.96 Very High Very High Very High
Age-related Macular Degeneration 64 99.76 Very High Very High Very High
Osteoarthritis 133 99.48 Very High Very High Very High
Metastasis 103 99.34 Very High Very High Very High
Inflammatory Bowel Disease 145 99.18 Very High Very High Very High
Infection 400 98.90 Very High Very High Very High
Arthritis 267 98.72 Very High Very High Very High
INFLAMMATION 544 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Incubation of confluent fibroblast cultures with varying concentrations (0.01-1.0 microgram/ml) of PGE2 led to a dose-dependent elevation of collagenase mRNA steady-state levels, the promoter activity, and the secretion of the protein, whereas relatively little effect was observed on stromelysin and TIMP gene expression.
Localization (secretion) of collagenase in PGE2
1) Confidence 0.74 Published 1994 Journal J. Cell. Biochem. Section Abstract Doc Link 8014195 Disease Relevance 0.17 Pain Relevance 0.25
Measurement of MMP- and TIMP-concentrations in blood plasma
Localization (Measurement) of TIMP in blood
2) Confidence 0.71 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.57 Pain Relevance 0.06
RPN 2610, RPN 2617, RPN 2613, RPN 2614, RPN 2611, RPN 2618, RPN 2612) for the determination of MMP1, MMP2, MMP3, MMP9, TIMP1, TIMP2, and MTC1 concentrations in the blood plasma of the patients and the control group.
Localization (concentrations) of TIMP1 in plasma
3) Confidence 0.71 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.12 Pain Relevance 0.05
Since MMPs and TIMPs are released from platelets and leukocytes into serum during blood collections [21] plasma should be used to determine circulating MMPs and TIMPs [22,23].
Localization (released) of TIMP in leukocytes associated with metalloproteinase
4) Confidence 0.68 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.63 Pain Relevance 0.51
The balance of secreted MMPs and their specific inhibitors (TIMPs) plays an important role in maintaining connective tissue homeostasis in normal tissue [11].
Localization (secreted) of TIMP in connective tissue associated with metalloproteinase
5) Confidence 0.68 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 1.06 Pain Relevance 0.32
Identification of TIMP1, IL18, RANTES, P-Selectin, MMP9, and L-Selectin as SJIA Plasma Flare Biomarkers
Localization (Identification) of TIMP1 in Plasma
6) Confidence 0.66 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.48 Pain Relevance 0.17
Plasma profiling of SJIA flare and quiescent samples using this antibody array identified a biomarker panel of TIMP1, IL-18, RANTES, P-Selectin, MMP9, and L-Selectin, all of which are present at higher abundance in SJIA flare than in quiescence.
Localization (panel) of TIMP1 in Plasma
7) Confidence 0.66 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.72 Pain Relevance 0.22
The antibody array plasma profiling identified an SJIA plasma flare signature consisting of tissue inhibitor of metalloproteinase-1 (TIMP1), interleukin (IL)-18, regulated upon activation, normal T cell expressed and secreted (RANTES), P-Selectin, MMP9, and L-Selectin.


Localization (secreted) of TIMP1 in T cell associated with metalloproteinase
8) Confidence 0.62 Published 2010 Journal Clin Proteomics Section Abstract Doc Link PMC2970804 Disease Relevance 0.85 Pain Relevance 0.18
There is some debate as to whether this reflects better or faster absorption of EPA and DHA as phospholipids or as triglycerides or whether it relates to a slower but equally effective absorption of EPA and DHA as ethyl esters (Rupp et al 2004).
Localization (absorption) of EPA
9) Confidence 0.61 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.15 Pain Relevance 0
No study using purified EPA found increases in DHA, strongly arguing against EPA being metabolized to DHA in large amounts.
Localization (metabolized) of EPA
10) Confidence 0.61 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.15 Pain Relevance 0
The VegEPA capsule contains:

• 280 milligrams of EPA from marine omega-3 fish oil • 100 milligrams of organic virgin evening primrose omega-6 oil • 1 milligram of the anti-oxidant vitamin E • An outer capsule made out of fish gelatine

Localization (milligrams) of EPA in capsule
11) Confidence 0.61 Published 2008 Journal Nutr J Section Body Doc Link PMC2248201 Disease Relevance 0.84 Pain Relevance 0.04
Whereas mice with targeted deletion of TIMP1 show CNV [79], homozygous TIMP3-null mice do not exhibit an obvious retinal phenotype [80].
Localization (deletion) of TIMP1 associated with age-related macular degeneration
12) Confidence 0.59 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 0.68 Pain Relevance 0
In the author's opinion, it is not clear whether there exists a meaningful difference in resorption or in the biological effects between ethyl ester or triglyceride forms of EPA and DHA.


Localization (forms) of EPA
13) Confidence 0.58 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.06 Pain Relevance 0
Eicosapentaenoic acid (EPA), which is found in omega-3 fish oils, has been shown to help depressive patients and can also be used to treat schizophrenia [41,42,59].
Localization (found) of EPA associated with depression and schizophrenia
14) Confidence 0.57 Published 2008 Journal Nutr J Section Body Doc Link PMC2248201 Disease Relevance 0.99 Pain Relevance 0.04
Individual preparations of TIMP-1, TIMP-2, TIMP-3, and TIMP-4 were reconstituted in PBS to 0.5 ?
Localization (preparations) of TIMP
15) Confidence 0.54 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.12 Pain Relevance 0
Relation of TIMP antibodies to clinical features of RA
Localization (Relation) of TIMP associated with rheumatoid arthritis
16) Confidence 0.54 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.74 Pain Relevance 0.35
Individual preparations of TIMP-1, TIMP-2, TIMP-3, and TIMP-4 were reconstituted in PBS to 0.5 ?
Localization (preparations) of TIMP-1
17) Confidence 0.54 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.12 Pain Relevance 0
Finally, the presence of TIMP-specific autoimmunity is associated with a nondestructive course of RA.


Localization (presence) of TIMP-specific associated with autoimmune disease and rheumatoid arthritis
18) Confidence 0.54 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.95 Pain Relevance 0.54
Individual preparations of TIMP-1, TIMP-2, TIMP-3, and TIMP-4 were reconstituted in PBS to 0.5 ?
Localization (preparations) of TIMP
19) Confidence 0.54 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.12 Pain Relevance 0
The antibody array plasma profiling identified an SJIA plasma flare signature consisting of tissue inhibitor of metalloproteinase-1 (TIMP1), interleukin (IL)-18, regulated upon activation, normal T cell expressed and secreted (RANTES), P-Selectin, MMP9, and L-Selectin.


Localization (secreted) of metalloproteinase-1 in T cell associated with metalloproteinase
20) Confidence 0.54 Published 2010 Journal Clin Proteomics Section Abstract Doc Link PMC2970804 Disease Relevance 0.86 Pain Relevance 0.18

General Comments

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