INT55689

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.02
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TIMP1) extracellular region (TIMP1)
Anatomy Link Frequency
cartilage 4
PGE2 2
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 15 100.00 Very High Very High Very High
Inflammatory stimuli 2 98.84 Very High Very High Very High
Osteoarthritis 48 95.36 Very High Very High Very High
cINOD 4 89.88 High High
Inflammation 32 88.40 High High
COX2 2 67.00 Quite High
rheumatoid arthritis 3 62.96 Quite High
Pain 17 50.00 Quite Low
Inflammatory mediators 1 40.00 Quite Low
cytokine 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 38 98.52 Very High Very High Very High
Arthropathy 2 96.48 Very High Very High Very High
Osteoarthritis 48 95.36 Very High Very High Very High
Injury 5 87.72 High High
Disease 10 73.32 Quite High
Ulcers 2 65.28 Quite High
Rheumatoid Arthritis 3 62.96 Quite High
Peptic Ulcer 2 60.48 Quite High
Pain 18 50.00 Quite Low
Death 4 41.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Incubation of confluent fibroblast cultures with varying concentrations (0.01-1.0 microgram/ml) of PGE2 led to a dose-dependent elevation of collagenase mRNA steady-state levels, the promoter activity, and the secretion of the protein, whereas relatively little effect was observed on stromelysin and TIMP gene expression.
Positive_regulation (elevation) of Transcription (levels) of collagenase in PGE2
1) Confidence 0.46 Published 1994 Journal J. Cell. Biochem. Section Abstract Doc Link 8014195 Disease Relevance 0.17 Pain Relevance 0.25
is a major determinant of catabolic events in cartilage, which results from the stimulation of matrix metalloproteinases (MMPs) transcription and translation, which in turn digest the cartilage matrix.
Positive_regulation (stimulation) of Transcription (transcription) of metalloproteinases in cartilage associated with metalloproteinase
2) Confidence 0.02 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1971260 Disease Relevance 0.56 Pain Relevance 0.26
and upregulates the transcription of a number of genes involved in cartilage degradation including iNOS, matrix metalloproteinases and COX-2, as well as IL-1?
Positive_regulation (upregulates) of Transcription (transcription) of metalloproteinases in cartilage associated with metalloproteinase
3) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582805 Disease Relevance 0.30 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox