INT55690

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Context Info
Confidence 0.50
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.77
Pain Relevance 3.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TIMP1) extracellular region (TIMP1)
Anatomy Link Frequency
macrophage 2
leukocytes 2
synovium 2
alveolar walls 2
PGE2 2
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 236 100.00 Very High Very High Very High
Inflammation 166 99.00 Very High Very High Very High
Arthritis 87 98.72 Very High Very High Very High
Infliximab 99 98.56 Very High Very High Very High
cytokine 170 98.52 Very High Very High Very High
rheumatoid arthritis 33 96.04 Very High Very High Very High
Osteoarthritis 81 95.72 Very High Very High Very High
Inflammatory mediators 3 93.72 High High
cINOD 20 89.88 High High
spinal inflammation 62 58.60 Quite High
Disease Link Frequency Relevance Heat
Infection 161 99.18 Very High Very High Very High
INFLAMMATION 165 99.00 Very High Very High Very High
Arthritis 95 98.72 Very High Very High Very High
Rheumatoid Arthritis 34 96.04 Very High Very High Very High
Osteoarthritis 83 95.72 Very High Very High Very High
Synovitis 1 89.24 High High
Stress 8 87.84 High High
Herpes Simplex Virus 238 87.52 High High
Pneumonia 18 84.40 Quite High
Cancer 52 83.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Incubation of confluent fibroblast cultures with varying concentrations (0.01-1.0 microgram/ml) of PGE2 led to a dose-dependent elevation of collagenase mRNA steady-state levels, the promoter activity, and the secretion of the protein, whereas relatively little effect was observed on stromelysin and TIMP gene expression.
Positive_regulation (elevation) of Localization (secretion) of collagenase in PGE2
1) Confidence 0.50 Published 1994 Journal J. Cell. Biochem. Section Abstract Doc Link 8014195 Disease Relevance 0.17 Pain Relevance 0.25
Finally, and most interestingly, increased TIMP-1 secretion by leukocytes in patients with IA shifted the balance toward an MMP-independent proteolytic activity in those SF with high NPA.
Positive_regulation (increased) of Localization (secretion) of TIMP in leukocytes associated with metalloproteinase and arthritis
2) Confidence 0.40 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779417 Disease Relevance 0.69 Pain Relevance 0.43
We then examined whether the decreased contribution of MMPs in those fluids with a high proteolytic activity correlated with an increased TIMP-1 secretion.
Spec (whether) Positive_regulation (increased) of Localization (secretion) of TIMP
3) Confidence 0.27 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779417 Disease Relevance 0.26 Pain Relevance 0.51
Synovial levels of matrix metalloproteinase-3 (MMP-3) and tissue inhibitors of matrix metalloproteinases (TIMP) are also elevated in SpA synovium and treatment with infliximab rapidly downregulates synovial expression of MMP-3 and TIMP and serum MMP-3 (Vandooren et al 2004).
Positive_regulation (elevated) of Localization (levels) of TIMP in synovium associated with infliximab and metalloproteinase
4) Confidence 0.18 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721298 Disease Relevance 0.35 Pain Relevance 0.56
This data also supported the cytokine antibody array data (Table S4), where pretreatment of cells by NS-398 up-regulated the release of TIMP-2 by 2.1 fold at 24 h PI.


Positive_regulation (regulated) of Localization (release) of TIMP associated with cytokine
5) Confidence 0.17 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.84 Pain Relevance 0.57
FigureĀ 5 shows that ARA treatment particularly increased expression of monocyte chemotactic protein (MCP)-1 and angiogenin, while EPA treatment increased IL-10, IL-6, macrophage inflammatory protein (MIP)-1?
Positive_regulation (increased) of Localization (treatment) of EPA in macrophage associated with inflammation
6) Confidence 0.16 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.28 Pain Relevance 0.27
B activity and the role of cyclooxygenase (COX)-enzymes, the experiments with the fatty acids ARA and EPA were repeated but now in our NF-?
Positive_regulation (acids) of Localization (repeated) of EPA
7) Confidence 0.16 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.09 Pain Relevance 0.14
One of the possible explanations is that lung infection damages the matrix of alveolar walls by promoting the release of metalloproteinases by activated neutrophils [18,19].
Positive_regulation (promoting) of Localization (release) of metalloproteinases in alveolar walls associated with metalloproteinase and infection
8) Confidence 0.04 Published 2007 Journal Crit Care Section Body Doc Link PMC2147711 Disease Relevance 0.79 Pain Relevance 0.17
Recent studies revealed that senescent cells from preneoplasic tissues also promoted ECM degradation via the secretion of metalloproteinases such as MMP-3 [52].
Positive_regulation (promoted) of Localization (secretion) of metalloproteinases associated with metalloproteinase
9) Confidence 0.01 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2845788 Disease Relevance 1.29 Pain Relevance 0.38

General Comments

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